更新于：2024-11-01

influenza A subtype H7N1 infection

H7N1流感

更新于：2024-11-01

基本信息

别名-

简介-

关联

项与 H7N1流感相关的药物

MI-1148

靶点

FURIN

作用机制

FURIN抑制剂

在研机构

Philipps University of Marburg

原研机构

Philipps University of Marburg

在研适应症

H5N1流感 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 H7N1流感相关的临床结果

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100 项与 H7N1流感相关的转化医学

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0 项与 H7N1流感相关的专利（医药）

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项与 H7N1流感相关的文献（医药）

2017-05-01·Journal of Virological Methods4区 · 医学

Evaluation of multiplex assay platforms for detection of influenza hemagglutinin subtype specific antibody responses

4区 · 医学

Article

作者: Horne, Bobbi J ; Levine, Min ; Limmer, Rebecca A ; Miller, Joseph D ; Hancock, Kathy ; Li, Zhu-Nan ; Wrammert, Jens ; Stevens, James ; Schwerzmann, Joy ; McCausland, Megan ; Weber, Kimberly M ; Katz, Jacqueline M ; Jernigan, Daniel B ; Phipps, Andrew J

Influenza hemagglutination inhibition (HI) and virus microneutralization assays (MN) are widely used for seroprevalence studies. However, these assays have limited field portability and are difficult to fully automate for high throughput laboratory testing. To address these issues, three multiplex influenza subtype-specific antibody detection assays were developed using recombinant hemagglutinin antigens in combination with Chembio, Luminex^®, and ForteBio^® platforms. Assay sensitivity, specificity, and subtype cross-reactivity were evaluated using a panel of well characterized human sera. Compared to the traditional HI, assay sensitivity ranged from 87% to 92% and assay specificity in sera collected from unexposed persons ranged from 65% to 100% across the platforms. High assay specificity (86-100%) for A(H5N1) rHA was achieved for sera from exposed or unexposed to hetorosubtype influenza HAs. In contrast, assay specificity for A(H1N1)pdm09 rHA using sera collected from A/Vietnam/1204/2004 (H5N1) vaccinees in 2008 was low (22-30%) in all platforms. Although cross-reactivity against rHA subtype proteins was observed in each assay platform, the correct subtype specific responses were identified 78%-94% of the time when paired samples were available for analysis. These results show that high throughput and portable multiplex assays that incorporate rHA can be used to identify influenza subtype specific infections.

2015-12-01·Veterinary Research2区 · 农林科学

Susceptibility to and transmission of H5N1 and H7N1 highly pathogenic avian influenza viruses in bank voles (Myodes glareolus)

2区 · 农林科学

ArticleOA

作者: Aiello, Roberta ; Romero Tejeda, Aurora ; Vascellari, Marta ; Berton, Valeria ; Salomoni, Angela ; Cattoli, Giovanni

The study of influenza type A (IA) infections in wild mammals populations is a critical gap in our knowledge of how IA viruses evolve in novel hosts that could be in close contact with avian reservoir species and other wild animals. The aim of this study was to evaluate the susceptibility to infection, the nasal shedding and the transmissibility of the H7N1 and H5N1 highly pathogenic avian influenza (HPAI) viruses in the bank vole (Myodes glareolus), a wild rodent common throughout Europe and Asia. Two out of 24 H5N1-infected voles displayed evident respiratory distress, while H7N1-infected voles remained asymptomatic. Viable virus was isolated from nasal washes collected from animals infected with both HPAI viruses, and extra-pulmonary infection was confirmed in both experimental groups. Histopathological lesions were evident in the respiratory tract of infected animals, although immunohistochemistry positivity was only detected in lungs and trachea of two H7N1-infected voles. Both HPAI viruses were transmitted by direct contact, and seroconversion was confirmed in 50% and 12.5% of the asymptomatic sentinels in the H7N1 and H5N1 groups, respectively. Interestingly, viable virus was isolated from lungs and nasal washes collected from contact sentinels of both groups. The present study demonstrated that two non-rodent adapted HPAI viruses caused asymptomatic infection in bank voles, which shed high amounts of the viruses and were able to infect contact voles. Further investigations are needed to determine whether bank voles could be involved as silent hosts in the transmission of HPAI viruses to other mammals and domestic poultry.

2009-06-01·Avian Diseases4区 · 农林科学

Serologic Evidence of Prevalent Avian H3 Subtype Influenza Virus Infection in Chickens

4区 · 农林科学

Article

作者: Earl G. Brown ; Zhe Wang ; Fu-lin Tian ; Jin-hua Liu ; Qin-fang Liu ; Zhan-lei Jiang ; Ji-hong Ma ; Juan Pu ; Guo-zhong Zhang ; Ying-ju Xia

H3-subtype influenza viruses are known to infect avian and mammalian species, including humans. However, little is known about the prevalence of H3 influenza virus infection in chicken populations in China. Therefore, a serologic survey of chickens was conducted in China to investigate the seroprevalence of avian H3-subtype influenza virus. Anti-H3 antibodies were assayed by using hemagglutination inhibition (HI) and confirmatory virus neutralization (VN) testing of 4598 serum samples, collected between July 2006 and June 2007, from 173 chicken flocks located in 18 areas that included 16 provinces and two municipalities. Seroepidemiologic results indicated that avian H3-subtype viruses were circulating in chickens in some regions of China, regions that included 12 of the 18 test areas, with an overall average prevalence rate of 2.83%. Samples from 44 of 173 flocks were HI/VN seropositive, including 15 flocks with levels that ranged from 10.00% to 41.94%. Significantly higher seroprevalence rates were observed in older chicken flocks and in those sampled in the cooler seasons. Standardized comparisons showed that Guangdong and Jiangsu, located in the south and east of China, respectively, had significantly higher levels of H3 seropositivity. For the first time, these results demonstrated serologic evidence for H3 avian influenza virus infection in chicken populations in several locations throughout China. These observations highlight the need for continued epidemiologic surveillance of the H3 subtype and for other low-pathogenic avian influenza viruses in China and other regions.