Dysbiosis

2024年9月19日到21日，中华医学会第二十四次全国消化系病学术会议（CGC）在沈阳新世界博览馆顺利开展，大会汇聚了国内外众多顶尖专家教授，共同探索消化病学的前沿动态与未来趋势，呈现了一场盛况空前、学术氛围浓厚的学术会议。 汇聚消化病学领域前沿力量 分享真知与探索 本次大会来自全国消化病学领域的医疗专家共计有5,000余人，通过多样的学术思维火花的碰撞、医疗技能的切磋，共同探讨当下消化病学领域的热点话题，为消化疾病治疗带来更多新观点与方法，同时也为消化病学领域的药物拓展和治疗方案打开新的思路，共同助力“健康中国”的建设。 作为生物制药企业，科兴制药致力于成为高品质生物药领导者，在研发、生产、使用等环节严格贯彻执行全生命周期的全面质量管理，持续提升产品质量，不断为医患带来更高临床价值、更精准治疗的药品。 公司在消化病学治疗领域拥有较丰富的产品矩阵。此次通过CGC会议这一国家级学术平台，科兴制药就消化领域的三个核心产品类停®(英夫利西单抗)、常乐康®（酪酸梭菌二联活菌散/胶囊）和克癀胶囊，分别针对成人溃疡性结肠炎、肠道菌群失调引起的相关性腹泻、急慢性肝炎引起的纳呆腹胀等消化疾病，与各参会专家和医护人员进行深入的学术交流和临床探讨，以期为临床提供更有效的用药方案。 聚焦消化病治疗领域 精准用药优化治疗路径 类停®是国内首个上市的英夫利西单抗生物类似药，其在药品安全及疗效上与原研药一致，有助于拓宽患者的治疗选择，提升药物的可及性与可负担性。 常乐康®（酪酸梭菌二联活菌散/胶囊）是生物制品一类新药，由酪酸梭状芽孢杆菌和婴儿型双歧杆菌联合而成，是说明书中明确老幼孕产妇均可使用的益生菌。常乐康自2002年上市以来，久经市场考验，其疗效和安全性也获得众多指南、共识、教材收录并推荐，备受广大临床医生和患者的肯定与信赖。 克癀胶囊针对消化领域的临床价值也在被不断挖掘和研究，克癀胶囊具有清热化湿解毒，活血化瘀散结等保肝作用，能通过改善肝功能减轻因急慢性肝炎导致的脾胃失调症状。且克癀胶囊凭借百年古方、多年的生产和临床应用历史，已收获多项专家共识与指南推荐。 建设健康中国任重道远，科兴制药将继续秉承“精益制药、精益用药、守护健康”的使命，为医患提供更多优质的用药选择，让更多好药惠及千家万户，为国民消化系统乃至全生命周期健康保驾护航！ 关于科兴制药 科兴生物制药股份有限公司（简称：科兴制药，股票代码：688136）是一家主要从事重组蛋白药物和微生态制剂的研发、生产、销售一体化的创新型国际化生物制药企业。专注于抗病毒、抗肿瘤、自免、肾病、消化、内分泌、退行性疾病等治疗领域，打造新型蛋白、新型抗体、核酸药物等前沿生物技术平台，坚持“创新+国际化”双轮驱动的平台型发展模式，同时探索生物技术在大健康领域的广泛应用，致力于成为高品质生物药领导者，服务全球患者。公司核心产品稳居国内同类品种前列，覆盖全国各省市地区约22700家终端，其中等级医院超7500家，已通过巴西、菲律宾、印度尼西亚等全球近40个国家的市场准入并实现销售。

CHICAGO, Sept. 11, 2024 /PRNewswire/ -- 32 Biosciences, pronounced "Three Squared Biosciences," proudly announces its emergence from stealth mode, with new microbiome diagnostic management tools and microbiome-based interventions. The company intends to revolutionize healthcare with its novel approach to gut microbiome medicine. Chronic diseases continue to pose a significant challenge despite years of progress in medical research and care. While medical advancements have extended lifespan, they have not necessarily improved health-span, partly due to a focus on treating illness rather than emphasizing preventive health. Additionally, scientists point to modern dietary habits and widespread antibiotic use as disrupting the gut microbiome—a crucial yet frequently neglected component of our health. The gut microbiome is increasingly recognized as a vital component of overall health, sometimes referred to as the sixth vital organ. Dysbiosis, or disruption of this intricate system, can lead to systemic inflammation, heightened infection risk, and a range of chronic diseases. As of now, there are no universally standardized measures for the functional health of the gut microbiome. 32 Biosciences is addressing this critical need with its gut microbiome platform technologies. One of its lead assets, GB-0001, is an advanced diagnostic management tool that aims to provide a standardized measure of functional gut microbiome health and have a direct impact on clinical decision-making. If approved, GB-0001 would help health care professionals monitor gut health while modifying medication and nutrition, ultimately restoring gut microbiome health. GB-0001 will also support the development of microbiome-based interventions for disease prevention and treatment such as CS-0003, a lead therapeutic asset intended to target virulent gene expression while promoting the growth of beneficial bacteria. Finally, 32 Biosciences plans to introduce science-based nutritional products to restore and maintain functional gut microbiome health. "At 32 Biosciences, we are pioneering a new approach to medicine by leveraging our advanced microbiome scientific research to create clinically validated physician management tools for diagnosing and addressing dysbiosis—an important factor in the development of many diseases," said Peter Farmakis, CEO. "Our intent is to better serve patients who currently have limited FDA-approved options and also to create significant financial value by addressing high unmet needs in large economic markets." The company's approach is built on research by scientific co-founders John Alverdy, MD, and Eugene Chang, MD, from The University of Chicago, and Joseph Pierre, PhD, from the University of Wisconsin-Madison. Their innovative microbiome research and development has been supported by $119 million in National Institutes of Health (NIH) grants. 32 Biosciences scientific founders partnered with The University of Chicago Duchossois Family Institute to produce GB-0001 and The University of Chicago Pritzker School of Molecular Engineering to produce CS-0003 technologies. About 32 Biosciences: 32 Biosciences is a healthcare company dedicated to advancing gut microbiome medicine. The company is committed to developing microbiome diagnostic management tools and microbiome-based interventions to enhance health-span by addressing the pivotal role of the gut microbiome in overall well-being. Established in 2023, 32 Biosciences was formalized as the parent company in April 2024 to wholly owned subsidiaries, Covira, established in 2018, and Gateway Biome, established in 2022. For more information, visit . Follow us on LinkedIn @32Biosciences. Media Contact: Julie Ferguson Healthcare Communications Consultant JFPR Media, LLC Email: [email protected] Phone: (312) 385-0098 SOURCE 32 Biosciences WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

THURSDAY, July 18, 2024 -- For solid organ transplant recipients, gut dysbiosis is associated with all-cause and cause-specific mortality, according to a study published online July 2 in Gut . J. Casper Swarte, from the University Medical Centre in Groningen, Netherlands, and colleagues analyzed 1,337 metagenomes derived from fecal samples of 766 kidney, 334 liver, 170 lung, and 67 heart transplant recipients from the TransplantLines Biobank and Cohort. An additional 8,208 metagenomes from the general population of the same geographical area were included to analyze gut dysbiosis. The association between multiple indicators of gut dysbiosis, including individual species abundances, and all-cause and cause-specific mortality was examined using multivariable Cox regression and a machine learning algorithm. The researchers identified two patterns representing microbiome community variation that were associated with all-cause and cause-specific mortality. There was an association between the gut microbiome distance between each transplantation recipient to the average of the general population with all-cause mortality and death from infection, malignancy, and cardiovascular disease. Twenty-three bacterial species that were associated with all-cause mortality were identified; a balance consisting of 19 of 23 species that were associated with all-cause mortality was identified by applying a machine learning algorithm. "Our results support emerging evidence showing that gut dysbiosis is associated with long-term survival, indicating that gut-microbiome targeting therapies might improve patient outcomes although causal links should be identified first," the authors write. The TransplantLines Biobank and Cohort study received funding from Astellas BV and Chiesi Pharmaceuticals BV.