Glucose Metabolism Disorders

Visionary healthcare company adds obesity and chronic care management provider to its curated selection of market-tested services NEW CANAAN, Conn., Oct. 31, 2024 /PRNewswire/ -- Muse Health, a care navigation integrator of value-based benefits, has partnered with FlyteHealth to offer its members expert obesity care and chronic condition management. Muse Health's vertically integrated healthcare system is focused on an individual's whole health through interactions with healthcare providers in primary and specialty care. FlyteHealth delivers a comprehensive suite of clinical care, technology and support, reducing the complexity and cost of obesity and comorbid chronic conditions for employers and payers. As Muse Health and its clients identified the growing need for a new way to approach diabetes, hypertension and weight management, they conducted extensive market analysis and determined that FlyteHealth is the ideal partner to service its clients' employees/members. "The more complex the challenges encountered by our stakeholders, the more we require robust solutions. FlyteHealth's best-in-class medical obesity solution and their mission-focused management and operations team made them a perfect partner to optimize lifestyles around food and activity in a culturally concordant manner," said Muse Health CEO Ricardo Johnson II. "We are excited to work alongside FlyteHealth to accomplish this important work." Muse Health partners with payers, pharmacy benefit managers (PBMs), group employers, associations, and other entities to ensure that value-based benefits are cognizant of social determinants of health, racial equalities, gender fairness, and economic stabilization. The company identifies, assesses, and manages a suite of value-based benefit providers that align with its strategic, moral obligations. They also secure claims data from clients, leverage proprietary risk-stratification programs, and steer individuals (Medicare and Medicaid beneficiaries, labor and group employees) to its vendor partners for services. As its portfolio vendor partners deliver their services, Muse Health manages collaborative strategies between its clients and vendor partners to reach individuals where they live in the manner that works best for them. "We are delighted to be part of the Muse Health virtual care ecosystem," said FlyteHealth CEO and co-founder Sloan Saunders. "We like the unique market approach Muse Health is taking to ensure that all individuals, including the most disadvantaged ones, have access to quality healthcare." For more information, contact: Ricardo Johnson II, CEO, Muse Health, [email protected] Gabe Castaneda, Chief Revenue Officer, FlyteHealth, [email protected] About Muse Health Muse Health provides an integrated health solution to our healthcare partners, working exclusively with payers, providers, and service entities to provide transformative solutions focused on underrepresented populations. Muse Health focuses on an individual's whole health and their engagement with healthcare providers in primary, secondary, and tertiary care markets. MUSE HEALTH technology platform is present in over 100 hospital systems and over a dozen payer networks. For more information, please visit About FlyteHealth FlyteHealth is obesity care that empowers you. Delivering a comprehensive suite of clinical care, technology, and support, FlyteHealth reduces the complexity and cost of obesity and its comorbid conditions for employers and payers. Based on the founders' decades of research and clinical care, FlyteHealth clinicians deliver the latest in personalized medication therapy and behavior coaching. The evidence-based treatment protocols enable individuals not only to lose weight and maintain weight loss long-term, but also to achieve significant improvements in outcomes related to diabetes, hypertension, heart disease, and many other weight-related health complications. Through the Flyte Intelligence obesity treatment platform, FlyteHealth empowers healthcare providers with subject matter expertise and care navigation services. Drawing from the largest data set of obesity and chronic disease research, Flyte Intelligence enables delivery of the highest standard of patient care at scale. For more information, please visit . Contact: FlyteHealth Nicole Turgeon [email protected] (206) 295-2060 SOURCE FlyteHealth WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

在药物研发的领域中，科学家们一直在探索新的分子结构和化学合成方法，以寻找更有效、更安全的药物。今天要给大家介绍的是一项来自伦敦帝国理工学院和辉瑞研发中心的研究，他们发现的「氧杂环丁烷和氮杂环丁烷磺酰氟」在药物发现中的巨大潜力。有感兴趣的朋友，点击“在看”与“转发”后，联系公众号助理索取原文！ 小分子杂环：药物设计的新宠 1.小分子杂环：药物设计的新宠 在药物化学中，精确控制分子的性质和构象是至关重要的。小分子极性基团，如氧杂环丁烷和氮杂环丁烷，因其独特的空间电子性质，成为了备受瞩目的生物电子等排体。它们可以模拟更常见官能团的性质，通过调整极性和氢键特性来增强药物与靶点的结合能力，同时还能影响药物的代谢稳定性、溶解度、吸收、分布和 pKa 值。 目前，已经有一些含有氧杂环丁烷的化合物进入了临床试验阶段，氮杂环丁烷在已批准的药物中也逐渐崭露头角。 多样的反应路径，丰富的化学结构 Defluorosulfonylative（deFS）耦合反应 OSF 和 ASF 试剂通过 deFS 反应途径，生成的碳正离子中间体可与多种亲核试剂耦合，从而合成了一系列新颖的化学结构。研究人员利用这一反应，合成了 11 种药物类似物，包括一些具有重要生物活性的分子，如治疗糖尿病诱导的免疫功能障碍的 SERCA 激活剂类似物，以及 MAPK14 抑制剂类似物等。 Sulfur–Fluoride Exchange（SuFEx）反应 在阴离子条件下，OSF 试剂还能通过 SuFEx 途径生成氧杂环丁烷 - 硫（VI）衍生物。通过调整溶剂和亲核试剂的强度，研究人员成功解锁了这一反应路径，为药物分子的设计提供了更多的选择。 合并药效团，创造新的药物设计元素 研究人员还探索了将氧杂环丁烷与其他极性官能团合并的可能性。例如，通过 deFS 反应将氧杂环丁烷与 NH - 唑、亚砜亚胺和含磷官能团等结合，形成了多种新颖的化学结构，这些结构可能作为有价值的新型生物电子等排体或替代基团，为药物化学家提供了新的设计思路。 含磷官能团作为药物化学结构单元尚未得到充分研究。膦酸酯和磷酸酯基团已被用于前药中以促进细胞膜通透性，而氧化膦在布加替尼获批后才开始受到更广泛的研究。人们越来越关注将这些结构单元引入类药分子中以调节 LogD 和溶解度。我们假设可以利用亚磷酸烷基酯试剂来捕获氧杂环丁烷碳正离子并提供相应的磷酸化氧杂环丁烷产物。 含有氧杂环丁烷的新型结构基元可进行进一步衍生化（方案 2d）。氧杂环丁烷叠氮化物59经铜催化的叠氮-炔烃环加成反应（CuAAC）生成三唑88，拓展了氧杂环丁烷 1,2,3 - 三唑的潜在应用范围。 氮杂环丁烷磺酰氟的独特魅力 首次报道的 ASF 试剂与 OSF 试剂具有相似的反应性。它可以通过 deFS 反应合成3-芳基-3-取代的氮杂环丁烷衍生物，并且与多种亲核试剂具有良好的兼容性，包括一些复杂的晚期示例，如氟西汀和氨氯地平的氮杂环丁烷功能化衍生物。此外，ASF 试剂还能通过 SuFEx 反应与醇盐反应，展示了其与复杂分子共轭的潜力。 在药物发现中的实际应用 PROTAC 连接子和分子胶设计在靶向蛋白质降解这一新兴领域中，OSF 和 ASF试剂展现出了独特的应用价值。研究人员利用这些试剂引入了cereblon-结合基序，为PROTAC连接子和分子胶提供了新的设计思路。这些新的设计可能改善其物理化学性质或溶解度特性，从而提高药物的疗效。 靶蛋白的降解 通过与 pomalidomide等E3连接酶配体的耦合反应，OSF和ASF试剂生成了新的降解剂基序，展示了它们在靶向蛋白质降解领域的应用潜力。这为开发新的药物治疗方法提供了新的途径。 结论与展望 这项研究展示了OSF和ASF 试剂在药物发现中的强大潜力。它们不仅可以通过多种反应路径合成具有新颖结构的化合物，还能为药物分子的设计提供新的思路和方法。未来，我们期待这些试剂能够在药物研发中得到更广泛的应用，为人类健康带来更多的福祉。 版权声明：本文内容及图片，如有侵权请联系删除。 免责声明：本文内容仅作信息交流学习，并不反映任何意见及观点。 往期推荐 乐威医药（欧洲）分公司正式成立 乐威医药沧州GMP生产基地高活生产线启用 乐威医药亮相意大利CPHI Milan 2024

精彩内容 日前，国家药监局官网显示，宜昌人福药业的复方醋酸钠林格注射液以仿制3类报产获批，视同过评。米内网数据显示，复方醋酸钠林格(钠钾镁钙葡萄糖)注射剂在近年中国公立医疗机构终端均超过10亿元销售规模，2024年上半年同比增长1.40%。今年以来，人福医药已有15款产品获批上市，19款产品报产在审。 来源：米内网一键检索 复方醋酸钠林格注射液主要用于循环血量及组织间液减少时细胞外液的补充，代谢性酸中毒的纠正。 近年中国公立医疗机构终端复方醋酸钠林格(钠钾镁钙葡萄糖)注射剂销售情况（单位：万元）来源：米内网中国公立医疗机构药品终端竞争格局 复方醋酸钠林格(钠钾镁钙葡萄糖)注射剂在近年中国城市公立医院、县级公立医院、城市社区中心以及乡镇卫生院（简称中国公立医疗机构）终端均超过10亿元销售规模，2024年上半年同比增长1.40%。米内网数据显示，复方醋酸钠林格注射液(钠钾镁钙葡萄糖注射液)有8家企业拥有生产批文，宜昌人福药业、江苏正大丰海制药、四川科伦药业等7家过评，石家庄四药、浙江医药新昌制药、辰欣药业等超10家企业以仿制3类报产在审，获批后视同过评。 10月26日，人福医药发布公告，其控股子公司宜昌人福药业的司美格鲁肽注射液以化学药品2.2类获批临床，同意本品开展2型糖尿病适应症的临床试验，目前全球尚无化学合成的司美格鲁肽产品上市。 今年以来，人福医药新品捷报频传，公司已有15款产品获批上市，19款产品报产在审，涵盖抗肿瘤和免疫调节剂、神经系统药物、消化系统及代谢药等多个治疗大类。资料来源：国家药监局官网、米内网数据库等注：米内网《中国公立医疗机构药品终端竞争格局》，统计范围是：中国城市公立医院、县级公立医院、城市社区中心以及乡镇卫生院，不含民营医院、私人诊所、村卫生室；上述销售额以产品在终端的平均零售价计算。如有疏漏，欢迎指正！ 本文为原创稿件，转载请注明来源和作者，否则将追究侵权责任。投稿及报料请发邮件到872470254@qq.com稿件要求详询米内微信首页菜单栏商务及内容合作可联系QQ：412539092 ●温馨提示● 因为微信公众号修改了推送规则，最近很多读者反映没有及时看到推文。 把米内网设为“星标”，就能每天与我们不见不散啦，具体操作如下： 【分享、点赞、在看】点一点不失联哦