Comparison The Postoperative Effects Of Local Antibiotic Versus Systemic Antibiotic With The Use Of Platelet Rich Fibrin On The Mandibular Third Molar Surgery

The aim of this study was investigate the comparison of postoperative effects of local antibiotics mixed with platelet-rich fibrin and postoperative systemic antibiotic applications prescribed for mandibular impacted third molar tooth extraction. The study included a total of 75 patients with impacted mandibular third molar. Patients were evaluated in 5 randomly separated groups. For the first and third group, Platelets Rich Fibrin+ systemic Antibiotics were applied into the tooth socket and for the second and fourth group, Platelets Rich Fibrin + local antibiotics were applied, respectively. There was a control group which only Platelets Rich Fibrin was applied into the socket. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation.

开始日期2019-03-17

申办/合作机构

Near East University

100 项与苯明青霉素相关的临床结果

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100 项与苯明青霉素相关的转化医学

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100 项与苯明青霉素相关的专利（医药）

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项与苯明青霉素相关的文献（医药）

2018-09-01·Veterinary world

The effect of dry cow therapy using systemic tylosin in combination with common intramammary medications on mastitis rate, cull rate, somatic cell count, and milk production in dairy cows affected with subclinical mastitis

Article

作者: Ismail, Zuhair Bani ; Muhaffel, Mohammad Musab ; Abu-Basha, Ehab

AIMS:

This study was performed to evaluate the effect of systemic tylosin on mastitis rates, cull rates because of mastitis, and quality and quantity of milk production in dairy cows affected with subclinical mastitis.

MATERIALS AND METHODS:

A total of 130 California mastitis test (CMT)-positive cows were randomly selected and divided into four different treatment groups. All treatments were performed on the day of drying off. Cows in Group 1 (n=34) received 12 g of tylosin intramuscularly (IM) and intramammary (IMM) 400 mg novobiocin sodium and 200,000IU penicillin G procaine. Group 2 (n=33) received 12 g tylosin IM and IMM 280 mg benethamine penicillin, 100 mg penethamate hydriodide, and 100 mg framycetin sulfate. Group 3 (n=33) received IMM alone with 400 mg novobiocin sodium and 200,000 IU penicillin G procaine. Group 4 (n=30) received IMM alone with 280 mg benethamine penicillin, 100 mg penethamate hydriodide, and 100 mg framycetin sulfate. The incidence and severity of clinical mastitis (CM), incidence of chronic mastitis, and cow cull rate because of mastitis were recorded during the first 100 days in milk (DIM). In addition, somatic cell count (SCC) and milk production parameters including the average days to peak milk yield, the average milk yield at peak, the average milk yield during the first 100 DIM, and the average 305-corrected milk yield were reported.

RESULTS:

The rate of CM was significantly (p≤0.05) less in Group 2 when compared between the current and previous lactations (30% vs. 64%). In Group 1 and 4, the rate of CM was decreased but not significant between the two lactations (59% vs. 79% and 63% vs. 77%, respectively) while in Group 3, the rate of CM was slightly increased (82% vs. 91%). When compared between the four groups in the current lactation, CM rate was significantly (p≤0.05) less in Group 2 compared to the other groups. A significant (p≤0.05) percentage of CM cases in Group 2 was classified as mild. In Groups 1 and 3, a significant (p≤0.05) percentage of CM cases was classified as moderate while severe clinical signs were recorded more significantly (p≤0.05) in Groups 3 and 4. The rate of chronic mastitis was significantly less in Group 1 and Group 2 in the current lactation compared to that in the previous lactation (6% vs. 12% and 0% vs. 6%, respectively). In Groups 3 and 4, the rate of chronic mastitis was not changed significantly when compared between the current and previous lactations. No cows were culled because of mastitis in Groups 1 and 3 while one cow was culled in each of Groups 2 and 4 during the first 100 DIM in the current lactation. The average milk yield during the first 100 DIM and the 305-corrected milk yield were significantly (p≤0.05) increased in Group 2 when compared between the previous and current lactations. Furthermore, cows in Group 2 produced significantly (p≤0.05) more milk during the first 100 DIM and significantly (p≤0.05) more 305-corrected milk yield compared to the other groups. In Group 2, the average SCC dropped significantly (p≤0.05) from 1,600,000 cells/ml at the start of the study to <200,000 cells/ml at 100 DIM.

CONCLUSIONS:

In dairy herds with subclinical mastitis, dry cow therapy of CMT-positive cows using a combination of tylosin (12 g, IM) and IMM administration of benethamine penicillin, penethamate hydriodide, and framycetin sulfate (Ubrostar; Boehringer Ingelheim, Germany) may result in a significant reduction of the rate and severity of acute and chronic mastitis and cull rates due to mastitis within the first 100 DIM. Furthermore, treated cows may produce significantly more milk with less SCC during the first 100 DIM and therefore produce significantly more 305-corrected milk in the lactation following treatment.

2009-01-01·JOURNAL OF DAIRY SCIENCE

Short communication: Effect of dry therapy using an intramammary infusion on bulk tank somatic cell count in sheep

Article

作者: Juárez, M.T. ; Martínez, A ; Carriedo, J A ; Gonzalo, C ; Beneitez, E. ; De La Fuente, L.F. ; Carriedo, J.A. ; De La Fuente, L F ; Gonzalo, C. ; Linage, B ; Linage, B. ; Beneitez, E ; Juárez, M T ; Martínez, A.

A total of 3,141 records of bulk tank milk somatic cell counts (BTSCC) and bulk tank milk total bacterial counts (BTTBC) were obtained over 24 mo from 25 dairy flocks of Assaf ewes belonging to the Consortium for Ovine Promotion in Castilla-León, Spain, in which a complete dry therapy program was carried out in 10,313 ewes using an antibiotic infusion containing 100 mg of penethamate hydriodide, 280 mg of benethamine penicillin, and 100 mg of framycetin sulfate. The selection criteria for all flocks were BTSCC mean values > or =1,000 x 10(3) cells/mL and absence of dry therapy before the start of this experiment. Significant effects on log BTSCC were detected for treatment, milking system, flock within milking system, month within flock by treatment, the interactions treatment by milking system and flock by treatment within milking system, and log BTTBC. After dry therapy was implemented, log BTSCC decreased significantly in machine-milked flocks (5.95 +/- 0.007) compared with values before antibiotic treatment (6.13 +/- 0.008). The effect was observed at the beginning of the second lactation posttreatment (5.98 +/- 0.013). However, dry therapy was not effective in hand-milked flocks, suggesting poor hygiene conditions. A significant relationship was found between BTSCC and BTTBC; therefore, programs for improving milk hygiene should be implemented for both BTSCC and BTTBC variables at the same time.

2008-09-01·Journal of dairy science1区 · 农林科学

Influence of an Intramammary Infusion at Drying-Off of Combined Penethamate Hydriodide, Benethamine Penicillin, and Framycetin Sulfate on Intramammary Infections and Somatic Cell Counts in Dairy Sheep

1区 · 农林科学

Article

作者: Gonzalo, C. ; Linage, B.

The dynamics of intramammary infection (IMI) during the dry period were studied in 435 half-udders of 229 Assaf ewes, belonging to 2 flocks with high and medium IMI prevalences. Ewes were randomly assigned to 2 lots: 1) treated lot (TL) with 223 half-udders (118 ewes), which received complete dry therapy (1 syringe/teat) of an antibiotic combination containing 100 mg of penethamate hydriodide, 280 mg of benethamine penicillin, and 100 mg of framycetin sulfate, and 2) control lot (CL) with 212 nontreated half-udders (111 ewes). Two samplings per half-udder were carried out on 2 different days in the 5 d preceding drying-off, and 2 other samplings were again carried out in the 5 first d of the postpartum period. The length of the dry period averaged 109.0 d. Cure, persistent infections, reinfection, and new infection rates were 81.7, 12.8, 5.5, and 7.9%, respectively, for TL and 13.3, 70.4, 16.3, and 22.8%, respectively, for the CL. The prevalence of IMI decreased significantly from 48.9% at drying-off to 13.0% at lambing for the TL, but it did not vary for the CL (46.2 and 52.4%, respectively). Within the TL, IMI prevalence significantly diminished for Staphylococcus (41.3 to 9.9%) and Streptococcus (5.8 to 1.8%) genera, and more specifically this decrease was most evident for Staphylococcus epidermidis and Streptococcus agalactiae species. Log somatic cell count (SCC) diminished significantly between drying-off (5.68) and lambing (5.33) in the TL, whereas log SCC did not vary in the CL (5.61 vs. 5.66). This SCC reduction was very significant in the flock with the greater IMI prevalence. As a conclusion, the antibiotic formulation used as dry therapy drastically diminished IMI prevalence and SCC during the dry period in dairy ewes as a result of greater IMI cure rates and lower reinfection and new infection rates in the TL compared with the CL.

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