Randomized, Double-blind, Comparative, Controlled Trial of Tolerability, Safety and Immunogenicity of the Flu-M Tetra Vaccine in Children Between 6 Months and 17 Years Old
The goal of this clinical trial is to assess tolerability, reactogenicity, safety and immunogenicity of the Flu-M Tetra vaccine as compared to the VaxigripTetra vaccine in terms of prevention of influenza in children aged 6 months to 17 years old inclusive.
Randomized, Double-blind, Comparative, Controlled Trial of Tolerability, Safety and Immunogenicity of the Flu-M Vaccine in Children Between 6 Months and 9 Years Old
Comparative trial of tolerability, reactogenicity, safety and immunogenicity of the Flu-M vaccine as compared to the Vaxigrip® vaccine in terms of prevention of influenza in children aged 6 months to 9 years (at the time of the first vaccination).
Multicenter, Double-blind, Comparative, Randomized Tolerability, Safety and Immunogenicity Trial of the Flu-M® Inactivated Vaccine in Volunteers Aged 18 to 60 Years
Comparative assessment of the tolerability, safety, and immunogenicity of the Flu-M® Inactivated Split Influenza Vaccine (without preservative) and the Flu-M® vaccine (with preservative) in volunteers aged between 18 and 60
Nanotechnology is revolutionizing the efficient production and sustainable development of modern agriculture. Understanding the pesticide activity of both nano- and conventional methods is useful for developing new pesticide formulations. In this study, three solid fluopyram formulations with varying particle sizes were developed, and the mechanisms underlying the difference in the antifungal activity among these formulations were investigated. Wet media milling combined with freeze drying was used to prepare fluopyram nanoparticles (FLU-NS) and a micron-sized solid formulation (FLU-MS), and a jet grinding mill was employed to fabricate fluopyram wettable powder (FLU-WP). The mean particle sizes of FLU-NS, FLU-MS, and FLU-WP were 366.8 nm, 2.99 μm, and 10.16 μm, respectively. Notably, FLU-NS displayed a toxicity index against Botrytis cinerea (gray mold) that was approximately double those of FLU-MS and FLU-WP. Similar trends were noticed in the antifungal tests on Alternaria solani. The uptake of FLU-NS by B. cinerea was approximately twice that of FLU-MS and FLU-WP, indicating that fluopyram nanoparticles are more easily taken up by the pathogen (B. cinerea), and display better bioactivity than the larger fluopyram particles. Therefore, the nanosizing of pesticides appears to be a viable strategy to enhance efficiency without increasing the amount of pesticide used.
2023-05-30·Transplantation and cellular therapy
Low incidence of relapse with moderate conditioning regimen of fludarabine, busulfan and melphalan for patients with myeloid malignancies: a single-center analysis of 100 patients.
作者: Jie-Ling Jiang ; Wen-Hui Gao ; Li-Ning Wang ; Ming Wan ; Ling Wang ; Jiong Hu
Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with standard myeloablative conditioning regimens such as Flu-Bu (fludarabine and busulfan) remains a major concern in patients with myeloid malignancies. A low relapse rate was reported when thiotepa or melphalan (Mel) were added to Flu-Bu, but this might increase the non-relapse mortality (NRM). Here, we evaluated the outcomes of 100 patients (70 acute myeloid leukemia, 23 myelodysplastic syndrome, 4 chronic myelomonocytic leukemia, and 3 granulocytic sarcoma) who received their first allo-HSCT after moderate-dose FBM conditioning regimen (fludarabine 150 mg/m2, busulfan 6.4 mg/kg, and melphalan 140 mg/m2, n=69; or lower-dose melphalan at 100 mg/m2 for patients over 55 years old and/or those with HCT-CI ≥3, n=31). The donors were HLA-matched siblings (n=19), unrelated donors (n=4), and haplo-identical donors (n=77). A total of 88% patients had an intermediate or high disease risk index (DRI). Out of 96 evaluable patients, 94 achieved neutrophil engraftment and had full donor chimerism on day 30. After a median follow-up of 468 days (range, 55-1039 days), only four patients relapsed with 2-year cumulative incidence of relapse (CIR) of 5.3%±3.6%. The 100-day and 2-year NRM were 6.8%±4.4% and 12.3%±3.6%, respectively. At last follow-up, the 2-year disease-free survival (DFS) and overall survival (OS) were 82.4%±4.2% and 80.3%±6.0%, respectively. Moreover, when comparing the transplantation outcomes between patients with melphalan 100 mg/m2 and 140 mg/m2, the NRM and CIR were not significantly different and the 2-year DFS and OS were similar in both groups, although the Mel 100 group was associated with a higher median age (58 vs 42 years, p<0.001) and a higher percentage of patients with HCT-CI ≥3 (p=0.005). For the whole group, the only independent factor associated with transplantation outcomes was HCT-CI ≥3, which led to higher NRM and inferior DFS and OS. Our study suggested that moderate-intensity FBM conditioning was feasible for patients with myeloid malignancies with a low relapse rate without increased NRM. A lower dose of melphalan at 100 mg/m2 maintained the low relapse risk without excess NRM for older adults. However, the FBM regimen should be used with caution in patients with high-risk HCT-CI (≥3).
2022-12-22·Pest management science
Calcium carbonate modified plant sporopollen capsule as an eco-friendly microvehicle for controlled release of pesticide.
作者: Sheng Xiang ; Huajun Kang ; Ali Chai ; Yanxia Shi ; Xuewen Xie ; Lei Li ; Tengfei Fan ; Baoju Li
In this work, natural club moss (Lycopodium clavatum, LC) spores with porous surface morphology and highly uniform size distribution were engineered into controlled-release microvehicles for pesticide delivery. As a proof of concept, a widely used fungicide-fluazinam (FLU) was successfully loaded into LC spores and then modified with different amounts of CaCO3 (CaC) to extend the efficacy duration of FLU. Significantly, as the control target of FLU, clubroot disease is a worldwide destructive disease to cruciferous crops, and its development is favored by acidic soils and can be suppressed under high Ca concentration.
By fabricating FLU@LC-CaC microcapsules, the FLU loading and CaCO3 deposition were systematically characterized by field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The as-prepared FLU@LC-CaC microcapsules showed sustained-release behaviors and were potentially able to supplement the Ca concentration in acidic environments. This approach synergistically enhanced the in vivo bioactivity for the on-demand control of clubroot disease. In vivo bioassay revealed that the control efficacy of FLU@LC-CaC against clubroot disease in pak choi (Brassica chinensis) (66.4%) was 1.7-fold higher than that of a commercial FLU suspension concentrate (38.2%) during the cultivation period (35 d).
This work provides new ideas not only for developing eco-friendly and scalable microvehicles for pesticide delivery based on natural sporopollen, but also for the unconventional research perspectives in on-demand pest management based on their characteristics of occurrence. This article is protected by copyright. All rights reserved.
100 项与 4-valent inactivated split influenza vaccine(St. Petersburg Research Institute of Vaccines and Sera) 相关的药物交易