Effectiveness of a Cranberry Extract Mouth- Rinse compared to a Sodium Fluoride Mouth Rinse on Microbial Counts in Caries Active Children- A Double Blind Randomized Controlled Trial
100 项与 蔓越莓提取物 相关的临床结果
100 项与 蔓越莓提取物 相关的专利（医药）
项与 蔓越莓提取物 相关的文献（医药）
2023-11-14·Phytotherapy research : PTR
The effects of blueberry and cranberry supplementation on blood pressure in patients with cardiovascular diseases: A systematic review and meta-analysis of randomized clinical trials.
作者: Felipe Mendes Delpino ; Francine Silva Dos Santos ; Thaynã Ramos Flores ; Henrique S Cerqueira ; Heitor O Santos
Blueberries and cranberries are berry fruits with the highest number of randomized clinical trials (RCTs) focusing on blood pressure (BP). This systematic review and meta-analysis of RCTs analyzed the effects of blueberry and cranberry supplementation alone and in concert with systolic BP (SBP) and diastolic BP (DBP) in patients with cardiometabolic diseases. The searches were performed until August 2023 in the following databases: PubMed, Scopus, Web of Science, Cochrane, and Embase. Studies that examined the effects of blueberry or cranberry intake/supplementation were included. The risk of bias was evaluated using the Rob 2 scale. A meta-analysis was performed to estimate the effects of blueberry and cranberry supplementation on BP levels in patients with cardiometabolic diseases. A total of 17 articles were included, from which two found significant results from blueberry and/or cranberry supplementation in reducing BP. Pooled results revealed statistically non-significant reductions of -0.81 mm Hg for SBP (95% confidence interval [CI]: -2.26, 0.63; I2 = 0%) and -0.15 mm Hg for DBP (95% CI: -1.36, 1.05; I2 = 27%). Blueberry and/or cranberry supplementation had neutral effects on SBP and DBP in patients with cardiometabolic diseases, regardless of duration or age. Further high-quality studies are needed to firmly establish clinical efficacy.
2023-11-10·The Cochrane database of systematic reviews
Cranberries for preventing urinary tract infections.
作者: Gabrielle Williams ; Christopher I Stothart ; Deirdre Hahn ; Jacqueline H Stephens ; Jonathan C Craig ; Elisabeth M Hodson
Cranberries contain proanthocyanidins (PACs), which inhibit the adherence of p-fimbriated Escherichia coli to the urothelial cells lining the bladder. Cranberry products have been used widely for several decades to prevent urinary tract infections (UTIs). This is the fifth update of a review first published in 1998 and updated in 2003, 2004, 2008, and 2012.
To assess the effectiveness of cranberry products in preventing UTIs in susceptible populations.
We searched the Cochrane Kidney and Transplant Specialised Register up to 13 March 2023 through contact with the Information Specialist using search terms relevant to this review. Studies in the Register are identified through searches of CENTRAL, MEDLINE, and EMBASE, conference proceedings, the International Clinical Trials Registry Platform (ICTRP) Search Portal and ClinicalTrials.gov.
All randomised controlled trials (RCTs) or quasi-RCTs of cranberry products compared with placebo, no specific treatment or other intervention (antibiotics, probiotics) for the prevention of UTIs were included.
DATA COLLECTION AND ANALYSIS:
At least two authors independently assessed and extracted data. Information was collected on methods, participants, interventions and outcomes (incidence of symptomatic UTIs, positive culture results, side effects, adherence to therapy). Risk ratios (RR) with 95% confidence intervals (CI) were calculated where appropriate. Study quality was assessed using the Cochrane risk of bias assessment tool. Confidence in the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
For this update, 26 new studies were added, bringing the total number of included studies to 50 (8857 randomised participants). The risk of bias for sequence generation and allocation concealment was low for 29 and 28 studies, respectively. Thirty-six studies were at low risk of performance bias, and 23 studies were at low risk of detection bias. Twenty-seven, 41, and 17 studies were at low risk of attrition bias, reporting bias and other bias, respectively. Forty-five studies compared cranberry products with placebo, water or no specific treatment in six different groups of participants. Twenty-six of these 45 studies could be meta-analysed for the outcome of symptomatic, culture-verified UTIs. In moderate certainty evidence, cranberry products reduced the risk of UTIs (6211 participants: RR 0.70, 95% CI 0.58 to 0.84; I² = 69%). When studies were divided into groups according to the treatment indication, cranberry products probably reduced the risk of symptomatic, culture-verified UTIs in women with recurrent UTIs (8 studies, 1555 participants: RR 0.74, 95% CI 0.55 to 0.99; I² = 54%), in children (5 studies, 504 participants: RR 0.46, 95% CI 0.32 to 0.68; I² = 21%) and in people with a susceptibility to UTIs due to an intervention (6 studies, 1434 participants: RR 0.47, 95% CI 0.37 to 0.61; I² = 0%). However, there may be little or no benefit in elderly institutionalised men and women (3 studies, 1489 participants: RR 0.93, 95% CI 0.67 to 1.30; I² = 9%; moderate certainty evidence), pregnant women (3 studies, 765 participants: RR 1.06, 95% CI 0.75 to 1.50; I² = 3%; moderate certainty evidence), or adults with neuromuscular bladder dysfunction with incomplete bladder emptying (3 studies, 464 participants: RR 0.97, 95% CI 0.78 to 1.19; I² = 0%; low certainty evidence). Other comparisons were cranberry products with probiotics (three studies) or antibiotics (six studies), cranberry tablets with cranberry liquid (one study), and different doses of PACs (two studies). Compared to antibiotics, cranberry products may make little or no difference to the risk of symptomatic, culture-verified UTIs (2 studies, 385 participants: RR 1.03, 95% CI 0.80 to 1.33; I² = 0%) or the risk of clinical symptoms without culture (2 studies, 336 participants: RR 1.30, 95% CI 0.79 to 2.14; I² = 68%). Compared to probiotics, cranberry products may reduce the risk of symptomatic, culture-verified UTIs (3 studies, 215 participants: RR 0.39, 95% CI 0.27 to 0.56; I = 0%). It is unclear whether efficacy differs between cranberry juice and tablets or between different doses of PACs, as the certainty of the evidence was very low. The number of participants with gastrointestinal side effects probably does not differ between those taking cranberry products and those receiving a placebo or no specific treatment (10 studies, 2166 participants: RR 1.33, 95% CI 1.00 to 1.77; I² = 0%; moderate certainty evidence). There was no clear relationship between compliance with therapy and the risk for repeat UTIs. No difference in the risk for UTIs could be demonstrated between low, moderate and high doses of PACs.
This update adds a further 26 studies, taking the total number of studies to 50 with 8857 participants. These data support the use of cranberry products to reduce the risk of symptomatic, culture-verified UTIs in women with recurrent UTIs, in children, and in people susceptible to UTIs following interventions. The evidence currently available does not support its use in the elderly, patients with bladder emptying problems, or pregnant women.
2023-10-01·Food science & nutrition
The role of alcohol extract of cranberry in improving serum indices of experimental metaproterenol-induced heart damage in rats
作者: Salmasi, Kimia ; Hassanpour, Ali ; Amouoghli Tabrizi, Bahram ; Moghaddam, Sina
Cranberry offers numerous cardiovascular benefits. According to several studies, this fruit promotes the oxidation of low-density lipoprotein, enhances high-density lipoprotein, reduces platelet coagulation, and improves vascular activity. Albino male rats were divided into five groups (n = 5 per group). The control group received intraperitoneal administration of normal saline. The second group was injected with metaproterenol (MET) 3 days a week for 4 weeks. The third, fourth, and fifth groups were given cranberry extract in doses of 75, 100, and 150, respectively, along with heart-damaging drugs. Blood samples were collected and sent to the laboratory on the fourth weekend and 1 week after completing the injections in the fourth week (the sixth weekend) for analyzing serum factors such as cardiac creatine kinase MB, cardiac troponin I (cTnI), and aspartate aminotransferase (AST). The serum activity of the cardiac evaluation parameters in the fourth week demonstrated a highly significant correlation among the groups with respect to AST and cTnI (p < .001). Additionally, a significant relationship was observed between AST and cTnI within the target groups (p < .05). Ultimately, the findings indicated that the consumption of cranberry extract, due to its impact on heart function, could effectively modify serum indicators associated with heart damage. The utilized extract also exhibited efficacy, albeit with variable effects. Therefore, it is recommended to use cranberry extract synergistically with other chemical and herbal medications to achieve more sustained effects.
The International Organization Prides Itself on Its Natural, Fast-Acting Formulas With Minimal Side Effects
FORT LAUDERDALE, Fla., Sept. 29, 2023 /PRNewswire/ -- PLAMECA is an international health brand with decades of experience developing, manufacturing, and distributing medicinal plants across the globe. While its previous focus has primarily been the Spanish geography, the company is in the process of entering the U.S. marketplace, where it hopes to give health conscious American consumers access to its signature natural, fast-acting formulas with minimal side effects.
"We have spent decades studying and understanding the ability of nature as a remedial option for human health," explains PLAMECA's managing director, Óscar Fernández. "In that time, we have become experts in phytotherapy and the art of only using natural ingredients to provide effective, fast-acting health solutions that are truly safe to use."
This combination of efficacy, speed, and safety lies at the heart of everything that PLAMECA's team does. The group starts by finding natural ingredients and combining them to produce effective solutions not just to general health but to specific problems.
Its CURARTI COLAGTIUM, for example, combines turmeric, collagen, hyaluronic acid, and vitamin C to provide fast-acting support for joint, bone, and skin health. CRANBYCYST MAX uses a high concentration of cranberry along with bearberry, Java tea, and vitamin C to effectively prevent or quickly combat UTIs (urinary tract infections).
While PLAMECA formulas have a reputation for producing real results, their natural ingredients also mean
they're remarkably safe compared to pharmaceutical alternatives. The brand's sleep support supplement, MELANOCTINA BILAYER, is a good example of this.
The sleep-enhancing agent uses natural ingredients, such as melatonin, passionflower, valerian, and lemon balm, to speed up the process of falling and staying asleep. As is always the case with a health remedy, there are minor concerns for natural ingredients of this nature.
Melatonin, for instance, can occasionally lead to a stomach ache or headache. However, these concerns pale in comparison to traditional sleeping pills, which come with a range of side effects, including diarrhea, hallucinations, and memory issues.
"For us, it's all about balancing the need to minimize side effects while maximizing speed and results," Fernández explains, "We have spent decades searching for effective, scientifically supported formulas that use natural ingredients with a quick effect. That way, anyone who uses a PLAMECA product can expect to see positive change in no time without the fear of additional concerns popping up along the way."
PLAMECA is a phytotherapy company founded in 1984 with the initial intention of providing medicinal herbs and plants — which it did for 1,500 retailers across the Spanish geography. In 1994, PLAMECA expanded to manufacture its own food supplements, creating a range of products using herbal extracts, vitamins, and minerals. Currently, PLAMECA products are manufactured in modern facilities using up-to-date scientific methods and are sold in 33 countries. The company has also invested $11 million in an aggressive plan to expand its health and wellness focus over the next five years. Learn more at plameca.com.
Juan M Desvalls
Tel. + 34 677518038
The Health Brand's Edible Vitamin and Mineral Strips Effectively Deliver Key Nutrients to the Gut Microbiome for Both Adults and Children
FORT LAUDERDALE, Fla., Sept. 29, 2023 /PRNewswire/ -- Soul Strips is an innovative health brand that has created a unique form of vitamin and mineral supplementation:
the oral strip. The Soul Strips team has developed a form of nanotechnology that allows it to infuse edible strips with essential nutrients targeted toward various basic bodily needs. Soul Strips' range of products (which will be available in American markets soon) includes products for the immune system, cognitive health, sleep aid, libido, energy, and more. It also has
a pair of adult and children's supplements for stronger gut health.
It's estimated that as many as 70 million Americans suffer from digestive conditions every year. These conditions span the gamut and can include major concerns like Crohn's or Celiac diseases. Others, like acid reflux, food intolerances, and IBS (irritable bowel syndrome), are less severe, though they can still sap quality of life and lead to further complications over time.
While they may vary in severity, all digestive concerns are important, and those managing them should talk to their doctor about treatment. As they explore their options, many find that often the best solution isn't a strong pharmaceutical one. It's simple nutraceutical preventative care.
"We consider it our sincere responsibility to transform the current wellness mentality," declares Soul Strips co-founder Sharath Madhavan. "We want to shift the narrative from 'eat chemical-based medicine when I'm sick' to 'take preventive care of my body and avoid health issues in the first place.'"
Madhavan adds that health should be an everyday pursuit. "That is why we're making nutritious formulations available in the oral strips form," he explains. "These have higher effectiveness and absorption than conventional pills, tonics, gummies, tablets etc."
This combination of efficacy and hyperconvenience makes Soul Strips an ideal way to maintain preventative health — including gut health — through nutraceutical supplementation. The brand's Gutsy gut health product delivers a potent dose of apple cider vinegar and a natural digestive enzyme combination that includes Protease, Amylase, and Lipase. Together, these ingredients help break down food, restore pH balance, and regain an equilibrium of good bacteria in the gut microbiome.
Soul Strips' Miss Digestion is a similar take on gut support for kids. It includes a probiotic blend and cranberry extract to restore bacteria balance and bolster the digestive system in younger bodies. In an era when digestive issues are rampant, Soul Strips' digestive supplements offer a convenient and effective way to boost gut health and ensure that the GI tract of adults and children alike are helping rather than hindering their health.
About Soul Strips
Soul Strips operates out of Dubai, UAE & Mumbai, India and was launched in 2020 by serial entrepreneurs Sharath Madhavan and Avinash Madhavan. The co-partners created the brand out of a vision to use cutting-edge nanotechnology to create hyper-convenient, uniquely bioavailable supplements for men, women, and children. Soul Strips products are sugar-free, preservative-free, and plant-based. They are a holistic health solution designed around preserving health and enhancing quality of life. Learn more at soulstripsglobal.com.
M: +971 526257044
SOURCE Soul Strips
The Health Brand's Impressive Range of Natural Supplements Addresses a Wide Variety of Symptoms and Conditions
FORT LAUDERDALE, Fla., June 30, 2023 /PRNewswire/ -- PLAMECA has a long track record of serving health-conscious consumers. The Spanish-based health brand specializes in the field of phytotherapy (the science of managing health conditions through plants, herbs, and their composite substances).
The company is in the process of entering the U.S. market. This will give Americans access to a wide range of clean, natural health and wellness products that span the gamut from digestional support to cardiovascular upkeep and much more.
"We've been working in the phytotherapy space since 1984," says Óscar Fernández, PLAMECA's Managing Director. "We're the experts when it comes to botanically-based medicinal remedies."
Fernández goes on to explain that PLAMECA only uses natural ingredients. "It doesn't matter if you're addressing cold and flu symptoms, treating tired legs, or anything in between. We've formulated plant-based and herbal formulas that can address symptoms without the harsh side effects that come from chemical ingredients."
A good example of this is the brand's CRANBYCYST MAX. The supplement is a popular way to maintain the upkeep of the urinary tract and avoid infections. It contains key natural ingredients known for having a positive impact on urinary tract health, including a high concentration of cranberry and gayuba (bearberry). It also reinforces the immune system via a dose of vitamin C. The supplement comes in boxes of thirty capsules. These can be taken once a day in the evening for maintenance or once in the morning and once in the evening for more intensive care.
CRANBYCYST MAX is just one of the many sweet, simple, safe, and effective supplements that PLAMECA has created throughout its nearly forty years as an international health and wellness brand. As it enters the United States market in the coming months, its range of affordable products will become increasingly available across various online and brick-and-mortar retailers, making it easier than ever for Americans to maintain their health on a daily basis.
PLAMECA is a phytotherapy company founded in 1984 with the initial intention of providing medicinal herbs and plants — which it did for 1,500 retailers across the Spanish geography. In 1994, PLAMECA expanded to manufacture its own food supplements, creating a range of products using herbal extracts, vitamins, and minerals. Currently, PLAMECA products are manufactured in modern facilities using up-to-date scientific methods and are sold in 33 countries. The company has also invested $11 million in an aggressive expansion plan to expand its health and wellness focus over the next five years. Learn more at plameca.com.
Juan M Desvalls [email protected]
Tel. + 34 677518038