预约演示

更新于：2025-05-07

Magnesium Sulfate/Potassium Chloride/Potassium Phosphate Monobasic/Sodium Chloride/Sodium Phosphate

硫酸镁/氯化钾/磷酸二氢钾/氯化钠/磷酸钠

更新于：2025-05-07

概要

基本信息

药物类型

小分子化药

别名

TIS-U-SOL IN PLASTIC CONTAINER

靶点-

作用方式-

作用机制-

治疗领域-

在研适应症-

非在研适应症-

原研机构

Baxter Healthcare Corp.

在研机构

Baxter Healthcare Corp.

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期

美国 (1981-10-06)

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式ClNa

InChIKeyFAPWRFPIFSIZLT-UHFFFAOYSA-M

CAS号7647-14-5

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关联

项与硫酸镁/氯化钾/磷酸二氢钾/氯化钠/磷酸钠相关的临床试验

NCT04870905

/ Not yet recruiting临床2期IIT

Tisleilizumab (PD-1 Antibody) and Chemoradiotherapy in Locoregionally-advanced Nasopharyngeal Carcinoma: a Phase 2 Trial

This trial intends to enroll patients with T4N1 or T1-4N2-3 (AJCC 8th) locoregionally-advanced nasopharyngeal carcinoma (LANPC). All the Patients will receive 3 cycles of induction chemotherapy with docetaxel and cisplatin and cisplatin based concurrent chemoradiotherapy (CCRT) plus adjuvant immunotherapy (tisleilizumab). All patients will receive intensity-modulated radiotherapy (IMRT). Tisleilizumab will begin 4-6 weeks after CCRT and continue every 3 weeks for 12 cycles.

开始日期2023-03-01

申办/合作机构

广州医科大学附属肿瘤医院

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100 项与硫酸镁/氯化钾/磷酸二氢钾/氯化钠/磷酸钠相关的临床结果

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100 项与硫酸镁/氯化钾/磷酸二氢钾/氯化钠/磷酸钠相关的转化医学

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100 项与硫酸镁/氯化钾/磷酸二氢钾/氯化钠/磷酸钠相关的专利（医药）

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项与硫酸镁/氯化钾/磷酸二氢钾/氯化钠/磷酸钠相关的文献（医药）

1980-01-01·Scandinavian Journal of Urology and Nephrology

The Effect of Chlorpromazine Pretreatment on the Vascular Function of Kidneys Damaged by Warm Ischaemia and Cold Storage in Collins' Solution

Article

作者: Dahlager, J. I. ; Bilde, T.

Vascular resistance was determined in 40 rabbit kidneys after graded warm ischaemia up to 60 minutes and preservation in Collins' solution for 24 and 48 hours. Half of the animals were treated with chlorpromazine 3.5 mg/kg before induction of the ischaemia. Vascular function was determined during short-term perfusion with TIS-U-SOL at 4 degrees C. The experiments showed that warm ischaemia of 30 and 60 minutes duration gave an increase in vascular resistance. The increase was, however, smaller in kidneys pretreated with chlorpromazine. Preservation in Collins' solution for 24 and 48 hours did not change this correlation. Determination of the weights and thereby formation of oedema showed that all kidneys preserved had a small increase in weight. No difference was found between pretreated kidneys and untreated kidneys. It is concluded that pretreatment with chlorpromazine is capable of diminishing vascular contraction during the warm ischaemic period and that preservation in Collins' solution for up to 48 hours does not alter this beneficial effect.

1976-06-01·Investigative ophthalmology

The phacoemulsification procedure. I. The effect of intraocular irrigating solutions on the corneal endothelium.

Article

作者: Marshall, W ; McCarey, B E ; Polack, F M

Irrigating solutions for intraocular purposes were evaluated for their possible damaging effects on the corneal endothelial cell structure and function. Rabbit corneal endothelium was perfused in vitro with Tis-u-Sol, Travenol Ringer's Solution, or Travenol Sodium Chloride. The irrigating solutions caused an immediate corneal swelling of 67 mum per hour +/- 5 (mean +/- standard error), which was not modified by a previous stabilization perfusion with glutathione-bicarbonate Ringer's (GBR). In contrast, the Plasma-lyte-148 solution which is used in the phacoemulsification procedure, did not cause corneal swelling for more than twenty minutes, and for more than sixty minutes if the cornea was perfused after a GBR stabilization. After more than sixty minutes of corneal swelling, endothelial intercellular junction separations appeared. This breakdown was present with the tested irrigating solutions except for Travenol Ringer's Solution, which contained calcium. Plasma-lyte was also evaluated in conjunction with the surgical phacoemulsification procedure. The complete procedure or just irrigation with ultrasound did not cause endothelial cell damage similar to a prolonged in vitro irrigation. Instead, endothelial cells were traumatically damaged in varying degrees by the surgical manipulations.

1974-06-01·The Journal of Parasitology4区 · 医学

Transfer of Immunity to Trichinella spiralis from Mother to Offspring

4区 · 医学

Article

作者: Perry, Ray H.

Mice born of mothers that had been sensitized to Trichinella spiralis by 2 infections with living larvae or by antigen-adjuvant injections were immune to a T. spiralis challenge when 3 weeks old. This immunity waned in the young mice by the 6th week of life. Experiments suggested that most of the immunity was passed from the mother to the young through the milk, with only minor placental passage indicated. Serologic tests demonstrated agglutinating trichinella antibodies in the sera collected from infected mothers, mice born and nursed by infected mothers, and mice born of normal mothers and fostered by infected mothers. Passive cutaneous anaphylaxis (PCA) tests were negative with these sera. The results indicated that the immunity in the baby mice was passively acquired from the sensitized mother and not actively produced by the young. The hypothesis of an antibody-mediated Arthus-type hypersensitivity is suggested. Several workers have observed the transfer of immunity to Trichinella spiralis from immune mothers to their offspring. Mauss (1940) demonstrated that the offspring of T. spiralisinfected rats, rabbits, and hamsters were less susceptible to infection with trichinella than were the offspring of uninfected controls. Culbertson (1943) showed that the transmission of immunity in rats was mediated through the milk suckled by the offspring. Little or no transmission of immunity through the placenta was thought to occur. Duckett et al. (1972) recently reported that mice born of uninfected mothers acquired immunity to trichinella when fostered by trichinella-immune mothers, but when the litters from immune mothers were fostered by uninfected mothers, no immune expulsion of adult trichinella was observed. The authors suggested that antibodies in the mothers' milk may be responsible for the passive immunity in the suckling mice. The present report, using Swiss mice from this Department, describes four experiments designed to determine whether immunity to trichinella is passed from mothers to their offspring. This strain of mouse has repeatedly manifested delayed (cellular) hypersensitivity to the intestinal phase of trichinella; however, Received for publication 20 August 1973. * Department of Medical Zoology, Walter Reed Army Institute of Research, Washington, D. C. 20012. many attempts to transfer immunity with hyperimmune sera have failed (Larsh, 1970). MATERIALS AND METHODS Swiss white mice were used for all experiments during this study. This strain has been maintained in this Department as a randomly outbred colony since 1943. The strain of T. spiralis was isolated originally from a pig in 1936. It was maintained in laboratory rats for the first 7 years after isolation, and since has been maintained in the abovedescribed Swiss mice. Larvae used for infection were obtained from mice infected approximately 3 months. The technique used for collecting and standardizing the infective inoculum was described by Larsh and Kent (1949) and later modified by Weatherly (1970). The methods for recovering and counting adult worms after a challenging infection were those used by Larsh and Kent (1949). The methods used for recovering and counting larvae were originally described by Larsh and Kent (1949). T. spiralis larvae used for antigen preparation were collected from infected mice by the technique described previously. The collected larvae were washed in commercially prepared physiologic soluion (TIS-U-SOL; Travenol Laboratories, Inc.). After 2 washings, the larvae were refrigerated (4 C) overnight in TIS-U-SOL (about 5.5 ml of TIS-U-SOL to 0.5 ml packed larvae). After this period, the antigen was prepared from these larvae as described by Larsh et al. (1969). Blood for serologic tests was collected from mice by orbital bleeding. Polyethylene tubing with an inside diameter of 0.047 and an outside diameter of 0.067 inch was cut into 3-inch lengths. One en of the tube was inserted into the orbital sinus, and the blood was collected in 10by 75-mm plastic tubes. The tubes were kept at room tem-

100 项与硫酸镁/氯化钾/磷酸二氢钾/氯化钠/磷酸钠相关的药物交易

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