葫芦巴提取物(Fenugreek Extract) - 在研适应症：疲劳，新冠肺炎后遗症，勃起功能障碍_专利_临床

概要

基本信息

药物类型

中药

别名

Testofen

靶点-

作用机制-

治疗领域

感染呼吸系统疾病泌尿生殖系统疾病+ [1]

在研适应症

疲劳新冠肺炎后遗症勃起功能障碍

非在研适应症-

原研机构

RDC Clinical Pty Ltd

在研机构

RDC Clinical Pty Ltd

非在研机构-

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

4

项与葫芦巴提取物相关的临床试验

NCT06006416 / Withdrawn临床3期

Effect of Fenugreek Fibre (Trigonella Foenum-graecum) on the Gut Microbiome in an Adult Population - an Open Label, Self-controlled Trial

A open label, self-controlled trial to evaluate the effect of Fenugreek Fibre (Trigonella foenum-graecum) on the gut microbiome in generally healthy adults aged 18-65 years old.

开始日期2024-12-01

申办/合作机构

RDC Clinical Pty Ltd

CTRI/2024/05/067789 / Recruiting临床3期

A randomized, double-blind, placebo-controlled, parallel-group, single center clinical study to evaluate the efficacy and safety of fenugreek extract in comparison with placebo in men with lower urinary tract symptoms and male menopausal symptoms - NIL

开始日期2024-06-01

申办/合作机构-

NCT05795816 / Recruiting临床3期

The Effectiveness of Testofen on Energy, Fatigue, Mental Acuity, and Other Quality of Life Symptoms Post COVID-19 Infection

This is a double blind, randomised, placebo-controlled trial to evaluate orally-dosed Testofen (a specialised extract of Trigonella foenum-graecum (Fenugreek) seed) compared to placebo on post COVID-19 symptoms in otherwise healthy participants 18 years and over.

开始日期2023-10-25

申办/合作机构

RDC Clinical Pty Ltd

100 项与葫芦巴提取物相关的临床结果

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100 项与葫芦巴提取物相关的转化医学

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100 项与葫芦巴提取物相关的专利（医药）

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437

项与葫芦巴提取物相关的文献（医药）

2025-03-01·Current Diabetes Reviews

Herbal Nanoformulations for Diabetes: Mechanisms, Formulations, and Clinical Impact

Article

作者: Sunita ; Kaushik, Rahul ; Parveen, Rehana ; Verma, Krishan Kumar

Background:Diabetes mellitus remains a global health challenge, demanding innovative therapeutic strategies. Herbal remedies have garnered attention for their potential in diabetes management, and recent advancements in nanotechnology have enabled the development of herbal nanoformulations with enhanced efficacy and bioavailability.Objective:This review aimed to comprehensively analyze the mechanisms, formulations, and clinical impact of herbal nanoformulations in managing diabetes mellitus.Method:A systematic literature search was conducted to identify relevant studies exploring the mechanisms of action, various formulations, and clinical outcomes of herbal nanoformulations in diabetes management.Result:Herbal nanoformulations exert their anti-diabetic effects through multiple mechanisms, including enhanced bioavailability, improved tissue targeting, and potentiation of insulin signaling pathways. Various herbal ingredients, such as bitter melon, fenugreek, and Gymnema sylvestre, have been encapsulated into nanocarriers, like liposomes, polymeric nanoparticles, and solid lipid nanoparticles, to enhance their therapeutic potential. Clinical studies have demonstrated promising results, showing improvements in glycemic control, lipid profile, and antioxidant status with minimal adverse effects.Conclusion:Herbal nanoformulations represent a promising avenue for the management of diabetes mellitus, offering improved therapeutic outcomes compared to conventional herbal preparations. Further research is warranted to optimize formulation strategies, elucidate long-term safety profiles, and explore the potential synergistic effects of herbal nanoformulations in combination therapies for diabetes management.

2024-12-01·Molecular Biology Reports

Variability in genome size of Trigonella foenum-graecum, Trigonella corniculata and Trigonella caerulea as estimated by flow cytometry indicates complex evolutionary history of fenugreek

Article

作者: Gaikwad, Ambika Baldev ; Rangan, Parimalan ; Yadav, Sheel ; Kumari, Ratna

BACKGROUNDThe determination of genome size is a fundamental step which provides a basis to initiate studies aimed at deciphering the genetic similarity of a species and to carry out other genomics based investigations. Fenugreek (Trigonella spp.) is an important spice crop which has numerous health promoting phytochemicals. Many species within this genus are known for their various health benefits owing to the presence of a wide diversity of important phytochemicals like diosgenin, trigonelline, fenugreekine, galactomannan, 4-hydroxy isoleucine, etc. It is a multipurpose crop being cultivated for food, animal feed and industrial purposes. Despite its importance, research on the genomics aspect of fenugreek remains scant. In the absence of sufficient genomic information, crop improvement in fenugreek is severely lagging.METHODS AND RESULTSEstimation of genome size of a species is the preliminary step for initiation of any genomic studies and therefore in the present study we have estimated the genome size for fenugreek. Here, we have determined the genome sizes of three different Trigonella spp. namely T. foenum-graecum, T. corniculata and T. caerulea through flow cytometry (FC). The 2 C DNA content values were found to be 6.05 pg (T. foenum-graecum), 1.83 pg (T. corniculata) and 1.96 pg (T. caerulea). The genome size of T. foenum-graecum is approximately three times the genome size of T. corniculata and T. caerulea. This variation in genome size of more than three-fold indicates the level of genetic divergence among the three species, though within the same genus.CONCLUSIONSThe differences observed in the genome sizes of the three species provide conclusive evidence of their genetic divergence. Additionally, the information about the genome size would provide an impetus to the structural and functional genomics-based research in this crop.

2024-11-05·Critical Reviews in Food Science and Nutrition

Fenugreek bioactive compounds: A review of applications and extraction based on emerging technologies

Review

作者: Hsieh, Chang-Wei ; Lin, Jenshin ; Majzoobi, Mahsa ; Farahnaky, Asgar ; Bannikoppa, Asha Mahesh ; Gavahian, Mohsen

Fenugreek (Trigonella foenum-graecum L.) is a pharmaceutically significant aromatic crop with health benefits linked to its phytochemicals. This article aims to overview progress in using emerging technologies to extract its bioactive compounds and extraction mechanisms. Also, the trends in the applications of this herb in the food industry and its therapeutical effects were explained. Fenugreek's flavor is the primary reason for its applications in the food industry. At the same time, it has antimicrobial, antibacterial, hepatoprotection, anticancer, lactation, and antidiabetic effects. Phytochemicals responsible for these effects include galactomannans, saponins, alkaloids, and polyphenols. Besides, data showed that emerging technologies boost fenugreek extracts' yield and biological activity. Among these, ultrasound (55.6%) is the most studied technology, followed by microwave (37.0%), cold plasma (3.7%), and combined approaches (3.7%). Processing conditions (e.g., treatment time and intensity) and solvent (type, ratio, and concentration) are significant parameters that affect the performance of these novel extraction technologies. Extracts obtained by sustainable energy-saving emerging technologies can be used to develop value-added health-promoting products.

100 项与葫芦巴提取物相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
疲劳	临床3期	澳大利亚	RDC Clinical Pty Ltd	2023-10-25
新冠肺炎后遗症	临床3期	澳大利亚	RDC Clinical Pty Ltd	2023-10-25
勃起功能障碍	临床3期	澳大利亚	RDC Clinical Pty Ltd	2022-04-19