Sch-202596(Sch-202596) - 药物靶点：galanin receptor_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

galanin receptor

作用方式

调节剂

作用机制

galanin receptor调节剂(Galanin receptors modulators)

治疗领域

肿瘤

在研适应症-

非在研适应症

肿瘤

原研机构

Schering-Plough Corp.

在研机构-

非在研机构

Schering-Plough Corp.

权益机构-

最高研发阶段无进展药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C25H22Cl2O12

InChIKeyLNGFWDFUPRZMJI-OUBRIYCOSA-N

CAS号196615-89-1

关联

100 项与 Sch-202596 相关的临床结果

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100 项与 Sch-202596 相关的转化医学

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100 项与 Sch-202596 相关的专利（医药）

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3

项与 Sch-202596 相关的文献（医药）

2002-02-01·Tetrahedron

Synthetic studies on Sch 202596, an antagonist of the galanin receptor subtype GalR1: an efficient synthesis of (±)-geodin, the spirocoumaranone part of Sch 202596

作者: Tadashi Katoh ; Osamu Ohmori ; Munenori Inoue ; Katsuhiko Iwasaki

An efficient and facile synthesis of (±)-geodin I corresponding to the spirocoumaranone part of Sch 202596 was accomplished in a convergent manner.The synthetic method features (i) a coupling reaction of the aryl aldehyde II with the aryl lithium generated in situ from the aryl bromide III to deliver the highly substituted diaryl methanol, and (ii) oxidative spirocyclization reaction of the benzophenone IV to construct the requisite spirocoumaranone skeleton [IV→(±)-I] as the key steps.The aromatic segments II and III were prepared from com. available Me 3,5-dihydroxybenzoate and 5-methylresorcinol, resp.

2000-01-01·Tetrahedron Letters

Studies toward the total synthesis of Sch 202596, an antagonist of the galanin receptor subtype GalR1: synthesis of geodin, the spirocoumaranone subunit of Sch 202596

作者: Tadashi Katoh ; Osamu Ohmori

An efficient synthesis of (±)-geodin corresponding to the spirocoumaranone subunit (I) of Sch 202596 was accomplished in a convergent manner by utilizing coupling reaction of the aryl aldehyde (II) with the aryl bromide (III) and oxidative spirocyclization of the benzophenone (IV) as the key steps.The aromatic segments II and III were prepared from com. available Me 3,5-dihydroxybenzoate and 5-methylresorcinol, resp.

1997-09-01·Tetrahedron Letters

A New Fungal Metabolite, Sch 202596, with Inhibitory Activity in the Galanin Receptor GALR1 Assay

作者: Arthur King ; Joseph Terracciano ; Vincent P Gullo ; Elpida Sapidou ; Pradip R Das ; Ronald Mierzwa ; Chu Min ; Mohindar S Puar ; Ellen Barrabee ; Robert Burrier ; Mahesh G Patel ; Imbi Truumees ; Stanley Mittelman

A novel spirocoumaranone, Sch 202596 (I), was isolated from the fermentation broth of Aspergillus sp.The isolation, structure elucidation and stereochem. of I are described.

100 项与 Sch-202596 相关的药物交易

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