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更新于：2025-03-20

Etheofazine

氮烯菲林

更新于：2025-03-20

概要

基本信息

药物类型

小分子化药

别名

EDMTP

靶点-

作用方式-

作用机制-

治疗领域

神经系统疾病

在研适应症-

非在研适应症

癌症疼痛

原研机构

University of Ioannina

在研机构-

非在研机构

University of Ioannina

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C11H17N7O2

InChIKeyOAQSALGVFQVOGT-UHFFFAOYSA-N

CAS号85609-79-6

关联

100 项与氮烯菲林相关的临床结果

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100 项与氮烯菲林相关的转化医学

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100 项与氮烯菲林相关的专利（医药）

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项与氮烯菲林相关的文献（医药）

2015-02-01·Physica Medica3区 · 医学

Samarium-153 EDTMP for metastatic bone pain palliation: The impact of europium impurities

3区 · 医学

Article

作者: Pallada, S ; Valakis, S T ; Kalef-Ezra, J A

PURPOSETo evaluate the impact on the radiation protection policies of the radiocontaminants in Samarium-153 ethylenediamine tetramethylene phosphonate ((153)Sm-EDTMP).METHODSThe internal contamination of patients treated with (153)Sm-EDMTP for palliation of painful disseminated multiple bone metastases due to long-lived impurities was assessed by direct measurements. These measurements were coupled with dose-rate measurements close to their bodies and spectroscopic analysis of the residual activity in post-treatment radiopharmaceutical vials.RESULTSWhole-body counting carried out in six patients showed a 30-81-kBq europium -152 plus europium-154 contamination. The 0.85 mean (152)Eu- to -(154)Eu activity ratio obtained by direct counting was similar to that assessed by analysis of post-treatment residual activities in twelve radiopharmaceutical vials following radiopharmaceutical injection.CONCLUSIONSThe long-lived radiocontaminants in the patient's bodies and the treatment wastes require modifications of the applicable radiation protection policies.

1992-01-01·Yao xue xue bao = Acta pharmaceutica Sinica

[Studies on biotransformation of etheofazine in isolated perfused rat liver].

Article

作者: Ruan, J X ; Xu, W M ; Min, Q W ; Zhang, Z Q

The biotransformation of etheofazine (EDMTP), a new anticancer drug, was studied by using isolated perfused rat liver. Two main metabolites were separated from the perfusate by HPLC and TLC and their chemical structures were determined by MS, 1H-NMR and IR. EDMTP-I is the parent compound. EDMTP-II is 7-ethyl-8-aminotheophylline. EDMTP-II was also separated and identified from the blood of mice after iv of 10 mg/kg. Species difference of biotransformation of EDMTP between rat and mouse seems to be not significant in this study.

Yaoxue Xuebao

Biotransformation of etheofazine in hepatic subcellular fractions from rat, dog and monkey

作者: Ruan, Jinxiu ; Xue, Junfeng

The biotransformation of etheofazine, a new anticancer drug, in hepatic subcellular fractions and its species differences were studied by determining the concentration of etheofazine, and its metabolite in hepatic 9000 x g supernatant fractions (S-9) and microsomes by HPLC.The in vitro liver intrinsic clearance of etheofazine in rat, dog and monkey liver S-9 was 14.9, 10.4 and 30.4 μL/min/mg protein, resp.The metabolite in hepatic microsome was 7-ethyl-8-aminotheophylline (EAT).There were insignificant species differences in metabolic profile of etheofazine.The results showed that hepatic subcellular fractions may be used as in vitro models for species difference study.

100 项与氮烯菲林相关的药物交易

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