Extravasation of calcium gluconate solution is a rare yet serious complication in neonatal intensive care units (NICUs), capable of causing significant skin necrosis, ulceration and long‐term functional impairment. This study reports a case of such injury and describes an effective, individualised strategy for wound management. An 18‐day‐old, 4200 g male infant, diagnosed with hypocalcaemia (serum calcium: 1.6 mmol/L) at a hospital in China, experienced calcium gluconate extravasation following peripheral intravenous supplementation. This complication resulted in localised skin swelling, ulceration and necrosis. After eight days of unsuccessful conventional management, the infant was transferred to a tertiary maternity and children's hospital in Sichuan, China. We implemented a structured treatment protocol involving combined debridement to excise necrotic tissue and calcium deposits. The wound was then managed with a tailored regimen: Lipido‐colloid dressings with silver ions were applied to control infection, alongside recombinant human epidermal growth factor gel to stimulate cellular regeneration. A moist wound environment was maintained using alginate hydrogel and foam dressings. The silver‐containing dressings were discontinued after 10 days upon resolution of erythema and cessation of exudate. The infant was discharged after a 32‐day course with satisfactory wound epithelialisation and full preservation of joint mobility. One‐year follow‐up confirmed normal limb function and the absence of scar contracture. A structured, individualised wound management strategy was effective in treating skin injuries resulting from calcium gluconate extravasation. The combination of surgical debridement, advanced wound dressings and adjunctive growth factor therapy facilitated tissue regeneration, promoted healing and supported functional recovery. An integrated protocol of surgical debridement, advanced wound dressings, and adjunctive growth factor therapy effectively fostered tissue regeneration, accelerated healing, and underpinned functional recovery.

2025-03-01·OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY

Experimental Study of Ultra-Pulsed CO2 Fractional Laser Combined With Recombinant Human Epidermal Growth Factor Gel in the Treatment of Eyelid Keloid

Article

作者: Qu, Yixin ; Li, Xingyi ; Lin, Xianchai ; Mao, Zhen ; Huang, Danping ; Chen, Rongxin ; Gao, Wuyou

Purpose::

Keloid (KD) and hypertrophic scars are prevalent and result from excessive growth of dermal tissue after skin damage. This review focused on the clinical application of the ultra-pulsed CO2 fractional laser combined with recombinant human epidermal growth factor (rHEGF) gel in patients with eyelid KD.

Methods::

Patients (N = 98) with KD who underwent surgery were randomly divided into a study group (ultra-pulsed CO2 fractional laser combined with rHEGF gel therapy, N = 49) and a control group (ultra-pulsed CO2 fractional laser therapy, N = 49). Besides, 5 cases dropped out of the study, including 2 cases in the study group and 3 cases in the control group. Finally, 47 cases of the study group and 46 cases of the study group were included in the analysis. The clinical baseline data such as sex, age, body mass index, scar area, etiology, Vancouver Scar Scale score, Patient and Observer Scar Assessment Scale score, four-item itch questionnaire score, serum interleukin-6 (IL-6), IL-10, and tumor necrosis factor-α level expression were recorded in the study group (N = 47) and the control group (N = 46).

Results::

There was no significant difference in gender, age, body mass index, scar area, etiology, Vancouver Scar Scale score, Patient and Observer Scar Assessment Scale score, 4-item itch questionnaire score, IL-6, IL-10, and tumor necrosis factor-α levels between the patients treated with ultra-pulse CO2 fractional laser + rHEGF gel and those only treated with ultra-pulse CO2 fractional laser (p > 0.05). Vancouver Scar Scale scores, Patient and Observer Scar Assessment Scale scores, and four-item itch questionnaire scores of patients with eyelid KD decreased to a greater extent than those treated with ultra-pulsed CO2 fractional laser combined with rHEGF gel (p <0.01). Compared with ultra-pulsed CO2 fractional laser treatment, ultra-pulsed CO2 fractional laser combined with rHEGF gel was more efficacious in treating patients with eyelid KD, with a lower incidence of adverse effects and a 1-year recurrence rate.

Conclusions::

Ultra-pulsed CO2 fractional laser combined with rHEGF gel can significantly improve the scar status and scar itching in patients with eyelid KD, with an obvious therapeutic effect, a low incidence of adverse effects, a 1-year recurrence rate, and high safety, which is worthy of popularization and application.

2024-06-01·The international journal of lower extremity wounds4区 · 医学

The Role of Leukocyte-Platelet-Rich Fibrin in Promoting Wound Healing in Diabetic Foot Ulcers

4区 · 医学

Article

作者: Wang, Yuqi ; Liu, Desen ; Cao, Hong ; Ruan, Siyuan ; Gu, Liuwei ; Chen, Rong ; Wang, Xiaotao

To explore the effect of leukocyte-platelet-rich fibrin (L-PRF) on promoting wound healing in diabetic foot ulcers. A total of 42 patients with diabetic foot ulcers at our hospital from January 2017 to July 2020 were retrospectively analyzed. A control group and a PRF group were established. The two groups of patients underwent debridement. In the platelet-rich fibrin (PRF) group, autologous L-PRF was used to cover ulcer wounds. One time each week, Vaseline gauze was used to cover the ulcer wounds. In contrast, the control group was treated with the external application of mupirocin ointment and recombinant human epidermal growth factor gel (yeast). Two times each week, the sterile Vaseline gauze was covered with a bandage. Both groups were treated for 5 weeks. The wound recovery of the two groups was observed. During the early stage of treatment (first and second weeks) for diabetic foot ulcers, the wound healing rate was significantly better with L-PRF treatment than traditional treatment. For later-stage treatment (third to fifth weeks), the overall cure rate was higher with L-PRF than the traditional treatment method. L-PRF can effectively promote wound healing in diabetic foot ulcers.

100 项与重组人表皮生长因子(桂林华诺威基因药业有限公司) 相关的药物交易

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