KH-002(KH-002) - 在研适应症：线粒体肌病_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用机制-

治疗领域

神经系统疾病内分泌与代谢疾病皮肤和肌肉骨骼疾病+ [1]

在研适应症

线粒体肌病

非在研适应症-

原研机构

Khondrion BV

在研机构

Khondrion BV

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构

分子式C20H31ClN4O4

InChIKeyWZJKWVZVSDEVJY-UHFFFAOYSA-N

CAS号1541170-36-8

关联

1

项与 KH-002 相关的临床试验

NCT05805618 / Not yet recruiting早期临床1期

A Single-center, Randomized, Double-blind, Placebo-controlled Phase I Clinical Study to Evaluate the Safety and Immunogenicity of Recombinant Norovirus Hexavalent Vaccine in Healthy Subjects Aged 18-59 Years

To evaluate the safety and immunogenicity of different dose levels of the Recombinant Norovirus Hexavalent Vaccine in healthy subjects aged 18-59 years given three doses of the vaccine at 28-day intervals.

开始日期2024-07-01

申办/合作机构

Syneos Health, Inc.

[+1]

100 项与 KH-002 相关的临床结果

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100 项与 KH-002 相关的转化医学

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100 项与 KH-002 相关的专利（医药）

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1

项与 KH-002 相关的文献（医药）

2010-09-01·Fish Physiology and Biochemistry3区 · 农林科学

Vitamin K-dependent γ-glutamylcarboxylase in Atlantic salmon (Salmo salar L.)

3区 · 农林科学

Article

作者: Ørnsrud, Robin ; Krossøy, Christel ; Lock, Erik-Jan

Due to problems with bone deformities in farmed Atlantic salmon, there is a growing interest in the possible involvement of vitamin K in normal bone development, and sensitive biomarkers for evaluating vitamin K status are therefore needed. The vitamin K-dependent (VKD) enzyme gamma-glutamylcarboxylase (GGCX, EC 6.4.x.x) requires vitamin K as a cofactor for its post-translational modification of glutamic acid (Glu) residues to gamma-carboxyglutamic acid (Gla) residues in VKD proteins, and is required for their function in haemostasis and bone metabolism. The present study was designed to evaluate the enzyme assay for GGCX activity in isolated liver microsomes and its distribution in the tissues of Atlantic salmon. The effect of KH(2) and menadione on the GGCX activity in salmon liver was also compared. Results from the present study show a widespread tissue distribution and expression of GGCX in Atlantic salmon. The GGCX activity and ggcx expression in all bony tissues examined imply the presence of vitamin K, and suggest the involvement of vitamin K in bone metabolism of Atlantic salmon. We propose the GGCX assay as a sensitive marker for vitamin K status, and confirm that menadione does not work as a cofactor for GGCX in Atlantic salmon liver.

100 项与 KH-002 相关的药物交易

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