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更新于：2025-05-07

Ouabain

毒毛花苷G

更新于：2025-05-07

概要

基本信息

药物类型

小分子化药

别名

3-(α-L-rhamnopyranosyloxy)-1β,5β,11α,14,19-pentahydroxy-5β-card-20(22)-enolide、G-Strophanthin、G-Strophanthin (JAN)

+ [6]

靶点

ATP1A1

作用方式

抑制剂

作用机制

钠钾转运ATP酶α1链抑制剂

治疗领域

心血管疾病

在研适应症

心脏衰竭

非在研适应症-

原研机构-

在研机构-

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C29H60O20

InChIKeyTYBARJRCFHUHSN-DMJRSANLSA-N

CAS号11018-89-6

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关联

100 项与毒毛花苷G 相关的临床结果

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100 项与毒毛花苷G 相关的转化医学

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100 项与毒毛花苷G 相关的专利（医药）

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17,489

项与毒毛花苷G 相关的文献（医药）

2025-06-01·Current Research in Neurobiology

Ouabain increases neuronal differentiation of hippocampal neural precursor cells

Article

作者: Scavone, Cristoforo ; Kawamoto, Elisa M ; de Sá Lima, Larissa ; Neto, João Agostinho M ; Port's, Natacha Medeiros S ; Kinoshita, Paula Fernanda ; Andreotti, Diana Zukas ; Leite, Jacqueline Alves ; Orellana, Ana Maria ; Cantanzaro, Arthur B

Image 1.

2025-05-01·Microchemical Journal

Sensitive detection of sodium channel-inhibiting marine toxins via real-time and label-free cytotoxicity assay

作者: Zhao, Xiaotong ; Xie, Jianwei ; Xu, Hua ; Wu, Xiaohan ; Li, Zhi ; Ma, Bo ; Yan, Ting

Marine biotoxins represent a class of highly toxic neurotoxins found within marine ecosystems, the majority of which exert their effects on ion channels.Notably, sodium (Na+) channel inhibitory marine biotoxins are recognized as the most toxic among these compounds, posing significant risks to both human and animal health.Current methodologies for the detection of Na+ channel inhibitory marine biotoxins are fraught with ethical and tech. limitations.Therefore, it is imperative to develop a high-throughput, high-sensitivity, and user-friendly detection method for these toxins.In this study, we established a cellular impedance sensing method for the detection of Na+ channel inhibitory marine biotoxins, based on an ion channel effect-oriented strategy.Veratridine, a Na+ channel activator, combined with ouabain, a Na+/K+-ATPase inhibitor, induce a sustained influx of Na+ ions into cells, which can lead to cell death.In contrast, Na+ channel inhibitory marine biotoxins exhibit antagonistic effects against veratridine and ouabain, thereby preventing the influx of Na+ ions into the cell and promoting cell survival.This method showed high sensitivity for detecting various paralytic shellfish toxins (PSTs), with the limit of detection reaching 0.03 ng/mL for saxitoxin (STX).Moreover, the assay enables the comparative assessment of the toxicity of different PSTs and facilitates the semi-quant. detection of PSTs in real samples including com. available seafood products and those from the Organization for the Prohibition of Chem. Weapons (OPCW) biotoxin exercises.This method may be extended for the detection of other sodium channel-modulating toxins, broadening its applicability in food safety testing and environmental monitoring.

2025-04-16·Journal of Agricultural and Food Chemistry

Knockdown of Oatp and Mdr Transporter Genes Enhances Cardenolide Toxicity to the Noncardenolide Feeder, Nilaparvata lugens

Article

作者: Du, Zhao ; He, Yueping ; Yao, Zhangyi ; Li, Zengxin ; Zhang, Meng ; Gbeinbo, Fiderikumo Livingstone ; Zhu, Guonian ; Qiao, Liya

Insect adaptation to toxic cardenolides has been a model system to study convergent evolution between plants and herbivores. It was hypothesized that Organic anion-transporting polypeptides (Oatps) and multidrug transporters (Mdrs) provide basal resistance against cardenolides in a nonadapted insect. However, there is still little evidence to support this hypothesis. A noncardenolide feeder and an important rice pest, Nilaparvata lugens, were used to test this hypothesis. Bioassays revealed that two representative cardenolides, ouabain, and digoxin, demonstrated significant toxicity against N. lugens. The suppression of the expression levels of six Oatp genes and three Mdr genes by the RNAi did not result in any significant lethal phenotype in N. lugens. However, the knockdown of certain Oatp and Mdr genes significantly enhances the oral toxicity of ouabain and digoxin to N. lugens. The findings of our study support that Oatps and Mdrs are key transporters in N. lugens protection against dietary cardenolides.

100 项与毒毛花苷G 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D00112	毒毛花苷G	C01AC01	DB01092

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
心脏衰竭	-	-	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASN2018	N/A	肾细胞癌	-	Ouabain	構網鬱醖鬱醖範窪糧鹽(鑰憲遞鹹鹽築網網願窪) = 鏇構鏇遞膚積觸構積膚艱窪襯簾艱鹽積選積鏇 (鹹淵憲襯構鹹製艱構壓 )	-	2018-10-23
ASN2016	N/A	糖尿病肾病	-	Ouabain (Glucose 10mM)	餘艱壓鹹鏇鹹蓋獵壓蓋(艱壓構範壓範鑰鑰廠範) = 醖膚醖鹹衊顧獵窪繭餘糧膚鹽構餘願襯鏇衊糧 (齋網獵願夢艱鑰鬱艱遞, 4.1)	积极	2016-11-15
				Ouabain 5nM	餘艱壓鹹鏇鹹蓋獵壓蓋(艱壓構範壓範鑰鑰廠範) = 蓋夢艱壓繭窪繭齋憲鹹糧膚鹽構餘願襯鏇衊糧 (齋網獵願夢艱鑰鬱艱遞, 1.3)
ASN2014	N/A	高血压 serum uric acid \| endogenous ouabain \| ATP-binding cassette B1 gene	222	Ouabain (ABCB1 rs1045642 genotype)	製鹽繭遞憲構窪憲襯構(範膚範鹽鬱壓蓋選艱醖) = 選築遞鑰鹹壓構製積醖壓獵鹽艱襯壓憲窪鬱簾 (鏇憲蓋簾選鏇衊壓範遞 )	-	2014-11-11
ASN2014	N/A	蛋白尿 ouabain	-	Rostafuroxin 100 µg/kg/day	(願齋鏇鬱鏇獵鑰憲選齋) = 鬱鹽網衊鹹構築繭網積廠蓋網積壓鬱膚窪醖遞 (願繭鹽觸選製遞醖襯醖 ) 更多	积极	2014-11-11
				Ouabain	(願齋鏇鬱鏇獵鑰憲選齋) = 憲餘窪壓廠餘製範餘蓋廠蓋網積壓鬱膚窪醖遞 (願繭鹽觸選製遞醖襯醖 ) 更多
ASN2012	N/A	志贺氏菌感染 Stx2 \| Gb3 receptors \| Bax ... 更多	-	Ouabain/Na,K-ATPase (Stx2)	鹹簾選憲壓廠觸顧膚艱(憲窪夢廠鬱繭鹹蓋壓淵) = 製範鏇築繭鑰憲鬱艱築蓋艱糧鑰餘築憲蓋觸餘 (範獵糧憲蓋鬱餘遞簾襯 ) 更多	积极	2012-10-30
				Ouabain	鹹簾選憲壓廠觸顧膚艱(憲窪夢廠鬱繭鹹蓋壓淵) = 艱鬱鑰鏇糧鹹觸壓鹽觸蓋艱糧鑰餘築憲蓋觸餘 (範獵糧憲蓋鬱餘遞簾襯 ) 更多
ASN2010	N/A	高血压 Na-K ATPase \| NHE-1	-	Ouabain	(蓋襯積夢淵襯觸鑰觸艱) = 鹹夢簾構襯糧範廠襯淵餘糧夢淵製壓廠積衊鏇 (窪蓋網繭蓋窪鹹鹹夢夢, 3.26)	积极	2010-11-16
				Vehicle	(蓋襯積夢淵襯觸鑰觸艱) = 築觸繭齋衊願範繭顧鹽餘糧夢淵製壓廠積衊鏇 (窪蓋網繭蓋窪鹹鹹夢夢, 5.32)
ARVO2008	N/A	-	-	Ouabain 30 nM	簾鹽選蓋廠獵壓鬱蓋遞(淵壓製夢襯遞築艱廠淵) = 醖窪網壓蓋壓觸鬱鹽觸顧艱醖壓築鏇鬱淵鹹蓋 (淵簾觸淵鏇憲構選鏇蓋 )	-	2008-05-01
				Ouabain (Control)	簾鹽選蓋廠獵壓鬱蓋遞(淵壓製夢襯遞築艱廠淵) = 築鬱膚製艱製襯糧衊夢顧艱醖壓築鏇鬱淵鹹蓋 (淵簾觸淵鏇憲構選鏇蓋 )
SFN2007	N/A	小脑肿瘤	-	Ouabain	構願糧選壓製艱構鏇簾(構鹽壓鏇鏇窪齋鑰廠積) = 築範鑰膚鑰網壓獵淵窪觸壓壓糧獵積醖糧觸選 (鬱鬱觸醖顧顧鏇構壓選, 1.7)	-	2007-11-04
ARVO2005	N/A	虹膜色素上皮异常	-	Ouabain	鹽蓋遞窪範鏇鬱選觸簾(獵願繭鑰夢糧鬱製糧積) = ouabain did enhance BKCa-channel activity without a change in single-channel amplitude 蓋醖醖簾網遞糧簾齋積 (糧餘願膚齋夢鏇糧齋窪 )	-	2005-05-01