Clinical study on changes in gut microbiota and the effect of bifidobacterium administration in postoperative patients with esophageal cancer - Clinical study on bifidobacterium administration in esophageal cancer patients

开始日期2022-06-29

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100 项与 Bifidobacterium(Biofermin Pharmaceutical Co., Ltd.) 相关的临床结果

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100 项与 Bifidobacterium(Biofermin Pharmaceutical Co., Ltd.) 相关的转化医学

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100 项与 Bifidobacterium(Biofermin Pharmaceutical Co., Ltd.) 相关的专利（医药）

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项与 Bifidobacterium(Biofermin Pharmaceutical Co., Ltd.) 相关的文献（医药）

2024-12-01·Current Microbiology

Effect of Hypoxia on the Gut Microflora of a Facultative Air-Breathing Loach Lepidocephalichthys guntea

Article

作者: Basak, Chandana ; Chakraborty, Ranadhir

One of the main risks to fish health in an aquatic environment is hypoxia, which can either lead to respiratory failure or the emergence of various diseases in a fish population. This investigation examined the impact of hypoxia on the gut bacteria of a loach, Lepidocephalichthys guntea, which under the dissolve oxygen stress can gulp air from surface and breathe using its posterior intestine. High-throughput sequencing was used to examine the anterior and posterior parts of the gut of L. guntea during both normoxia and hypoxia. According to the community profiling of the gut bacteria, prolonged exposure to hypoxia increased the diversity and abundance of bacteria in the posterior part while decreasing both in the anterior part of the gut. Additionally, for both parts of the gut, the core microbiota showed a significant alteration during hypoxia. In correlation network analysis, a more interactive and intricate network was developed at normoxia. According to the comparative analyses of the gut bacteria, hypoxia causes more pronounced alterations in the posterior gut than the anterior gut at various taxonomic levels. As a consequence of hypoxia, several genera like Aeromonas, Pseudomonas, Plesiomonas, Acinetobacter, and Enterobacter were replaced by Streptococcus, Escherichia-Shigella, Janthinobacterium, and Clostridia. A surge in probiotic genera, including Bifidobacterium, Lactobacillus, Blautia, and Cetobacterium, was also seen. The fatty acid biosynthesis pathway was induced only in hypoxia, although all other metabolic pathways were present in both situations, albeit with fewer hits in hypoxia.

2024-11-01·Brain, Behavior, and Immunity

Gestational administration of Bifidobacterium dentium results in intergenerational modulation of inflammatory, metabolic, and social behavior

Article

作者: Gur, Tamar L ; Woodke, Samantha T ; King, Mackenzie K ; Galley, Jeffrey D ; Batabyal, Anandi ; Rajasekera, Therese A

Prenatal stress (PNS) profoundly impacts maternal and offspring health, with enduring effects including microbiome alterations, neuroinflammation, and behavioral disturbances such as reductions in social behavior. Converging lines of evidence from preclinical and clinical studies suggest that PNS disrupts tryptophan (Trp) metabolic pathways and reduces gut Bifidobacteria, a known beneficial bacterial genus that metabolizes Trp. Specifically, previous work from our lab demonstrated that human prenatal mood disorders in mothers are associated with reduced Bifidobacterium dentium in infants at 13 months. Given that Bifidobacterium has been positively associated with neurodevelopmental and other health benefits and is depleted by PNS, we hypothesized that supplementing PNS-exposed pregnant dams with B. dentium would ameliorate PNS-induced health deficits. We measured inflammatory outputs, Trp metabolite levels and enzymatic gene expression in dams and fetal offspring, and social behavior in adult offspring. We determined that B. dentium reduced maternal systemic inflammation and fetal offspring neuroinflammation, while modulating tryptophan metabolism and increasing kynurenic acid and indole-3-propionic acid intergenerationally. Additional health benefits were demonstrated by the abrogation of PNS-induced reductions in litter weight. Finally, offspring of the B. dentium cohort demonstrated increased sociability in males primarily and increased social novelty primarily in females. Together these data illustrate that B. dentium can orchestrate interrelated host immune, metabolic and behavioral outcomes during and after gestation for both dam and offspring and may be a candidate for prevention of the negative sequelae of stress.

2024-10-15·Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

益生菌预防婴幼儿抗生素相关性腹泻的前瞻性随机对照研究.

Article

作者: Zhang, Su-Wei ; Zhi, Xian ; Shen, Dong-Lin ; Wang, Meng-Yu

目的: 评价布拉氏酵母菌散及双歧杆菌四联活菌片对婴幼儿抗生素相关性腹泻（antibiotic-associated diarrhea, AAD）的预防作用。方法: 选取2023年7—12月因非胃肠道感染入住徐州医科大学附属医院儿科并需抗生素治疗的3岁以下患儿作为研究对象，采用随机数字表法随机分为对照组（n=47）、布拉氏酵母菌组（n=70）、双歧杆菌组（n=65）。对照组根据相关诊疗规范应用抗生素及对症支持治疗。除对照组采用的治疗外，布拉氏酵母菌组和双歧杆菌组分别加用布拉氏酵母菌散和双歧杆菌四联活菌片治疗，并根据益生菌使用时间将布拉氏酵母菌组分为布拉氏酵母菌7 d、14 d、21 d组和双歧杆菌7 d、14 d、21 d组。比较各组患儿应用抗生素后AAD发生率和粪便球菌与杆菌比例。结果: 布拉氏酵母菌组和双歧杆菌组的AAD发生率均低于对照组（P<0.017）。布拉氏酵母菌组和双歧杆菌组AAD持续时间和住院时间均短于对照组（P<0.05）。对照组在第7天、14天、21天的粪便球菌与杆菌比例均高于第1天（P<0.05）。组内比较显示，双歧杆菌14 d组、21 d组在治疗第14天的粪便球菌与杆菌比例低于第1天（P<0.05）；对照组、布拉酵母菌14 d组、布拉酵母菌21 d组、双歧杆菌14 d组、双歧杆菌21 d组在治疗第14天的粪便球菌与杆菌比例低于第7天（P<0.05）；对照组、布拉氏酵母菌21 d组在治疗第21天时粪便球菌与杆菌比例低于第7天及第14天（P<0.05）。组别间比较显示，第7天时，布拉氏酵母菌7 d、14 d、21 d组以及双歧杆菌7 d、14 d、21 d组粪便球菌与杆菌比例均低于对照组（P<0.05）；第14天时，双歧杆菌14 d组和21 d组粪便球菌与杆菌比例均低于对照组和双歧杆菌7 d组（P<0.05）。结论: 布拉氏酵母菌和双歧杆菌四联活菌均能有效改善肠道菌群，预防婴幼儿AAD的发生；与短期治疗相比，适当延长益生菌疗程可进一步改善肠道菌群结构。.

项与 Bifidobacterium(Biofermin Pharmaceutical Co., Ltd.) 相关的新闻（医药）

2024-10-27

·梅斯医学

复旦大学惊人发现：仅3天的厨房烹饪油烟，就能引起肺炎和损伤肠道！持续7天更严重

所谓民以食为天，中国人对家的热爱，可能有一半都倾注在了厨房里。在传统中国人的厨房中，无论是最常见的烹饪方式爆炒、煎炸，还是偶尔做个大餐会使用到的烧烤、油焖，这些方式带来了无数的色香味俱全的美味佳肴，但同时也存在着浓浓的烟火气。当然，说得好听点是“烟火气”，其实就是烹调油烟（COFs）。COFs由烹调油或食物成分在高温烹饪过程中热分解或热解产生的颗粒物和气体物质组合而成，是室内空气污染物的主要来源之一。 COFs中含有多种有害物质，比如多环芳烃、丙烯醛等，长期吸入可能会对人体健康造成损害。调查数据显示，非吸烟者的肺癌发病率增加了2倍，背后的主要致病因素便是COFs。《柳叶刀》上曾刊登过一篇全球性的调研评估，将厨房烟雾污染列为重大健康问题隐患，排序仅次于高血压、抽烟和酗酒。近日，来自复旦大学的研究团队从元基因组学、转录组学和代谢组学等多方面揭露了COFs的“邪恶嘴脸”。仅仅3天时间，吸入COF就能诱发肺部炎症，并导致胃肠道功能紊乱；持续7天的暴露会破坏肠道微生物群并改变色氨酸代谢；而14天之后则会观察到进一步变化（适应性反应）。也就是说，COFs的健康危害不局限于呼吸系统，还会“流窜”至远端器官肠道，影响全身健康。没想到啊没想到，竟然被“烟火气”背刺了！ doi: 10.1021/acs.est.4c06035 COFs由复旦大学的烹调油烟形成与暴露设备（COFFEE）产生，该设备包括了四个部分：COF生成系统、通风管道、动物暴露仓以及采样和监测管道。考虑到大豆油的广泛使用以及加热大豆油能产生“典型”的COFs，研究者选用了加热大豆油来产生COFs。整个加热过程中，油温保持在200°C左右，产生的PM2.5浓度为23-30mg/m3。为了复刻人类短期暴露于COFs的情况，研究者将实验小鼠连续14天暴露于COFs中，每天2次（每日上午9点和10点），每次持续30分钟。其中，30分钟包括了加热100mL大豆油并产生COFs的20分钟，以及停止加热后的10分钟。 COFFEE设备情况在小鼠接触COFs的第0、3、7、14天，研究者分别记录下小鼠的多组学情况变化。仅仅3天的暴露，研究者就观察到小鼠体内的炎症标志物的水平变化。具体来说，随着暴露时间的增加，肺部的白介素IL-6水平持续增加，并在第3天达到峰值；而IFN-γ水平在第1和2天几乎不变，但第三天开始出现“跃升”。事实上，IL-6和IFN-γ均是炎症反应的关键调节因子，在促进和抑制炎症的过程中都发挥着重要作用。同时，这些细胞因子的上调与炎症反应的严重程度直接相关，即IL-6和IFN-γ的水平越高，意味着越严重的炎症反应。但炎症标志物水平的变化并不局限于肺部，研究者还在肠道组织中观察到了IFN-γ水平的升高。不过值得注意的是，COFs虽然引起了小鼠肠道内炎症反应调节因子的升高，但它并不是导致炎症性肠病（IBD）的直接原因，而可能是通过促炎机制增加了IBD的发生风险。暴露于COFs的小鼠的炎症标志物水平随着暴露于COFs的时间不断延长，小鼠肠道组织的病理学损伤也越来越明显。与暴露前相比，暴露第3天后，肠道脂肪有所减少，且略有紊乱；到了COFs暴露的第7天，肠道脂肪表现出严重的解离，同时杯状细胞的凝聚性也明显受损，与IBD的临床症状一致。然而，有意思的是，到了第14天，研究者却观察到了肠道脂肪细胞的聚集，说明小鼠肠道可能出现了适应性改变。器官重量的变化被广泛认为是化学物质对器官造成损伤的高敏感指标之一。于是，研究者进一步测量了不同暴露时间下肠道质量的差异，发现了类似的现象：和基线相比，暴露COFs第3天和第7天之后，小鼠的肠道质量和相对器官重量均显著降低；但到了第14天却出现了“反弹”。不同COFs暴露时间下肠道切片特征区别研究者进一步对小鼠进行了宏基因组分析、肠道菌群分析和色氨酸代谢分析，从多方面确认了厨房烹饪油烟诱发肠道疾病IBD的机制。 1）基因组学改变：对IBD的基因组学检测发现，随着暴露于COFs的时间不断增加，与IBD息息相关的TLR5、MHCII、TCR、IL12Rβ1和TLRs等基因表达出现了明显的变化。举例来说，MHCII是一种有助于提升肠道消化能力、抵御IBD压力的重要基因，其介导的抗原呈递是推动CD4+ T细胞协调免疫反应的基础。在基线时，MHCII的表达为50%；但到了第3天时，竟然没有表达；不过，到了第7天和第14天时，MHCII表达回到了12.5%。 IBD生物特异性通路图以及不同暴露时间下小鼠的IBD基因表达 2）肠道菌群分析：对暴露于COFs小鼠的肠道菌群进行分析发现，从基线到第3天和第7天，肠道菌群种类的总计数从最初的119减少到109和62，但第14天稍稍反弹回了97。而具体到特有的细菌群发现，随着暴露时间的不断增加，多种肠道菌群的丰度均表现出不同程度的变化。比如：在暴露于COFs的第3天，Lactobacillus、Bacillus和Escherichia-Shigella的数量显著增加，但Dubosiclla、Bifidobacterium和Munribaculaceae的数量却有所减少。事实上，Lactobacillus和Escherichia-Shigella这两种肠道菌有助于蛋白质降解并增强对肠炎的抵抗力，同时Bacillus是一种能有效减轻由肠炎引起的应激症状的益生菌。换言之，在COFs诱导IBD的早期阶段，肠道微生物群的组成发生了明显的变化，以抵抗与IBD相关的应激。但到了第7天，研究者观察到Lactobacillus的数量显著增加，但伴随着其他细菌物种的丰度减少，甚至某些肠道菌群直接“消失”。这些变化与IBD相关基因表达的发现一致，暗示着暴露于COFs的7天后诱发了严重的IBD。不过在14天的暴露后，肠道微生物群物种的丰度又略有增加，可见IBD在14天后略有缓解。肠道菌群分析情况 3）色氨酸代谢分析：色氨酸代谢可作为IBD发展的实时指标，与IBD有着千丝万缕的联系。研究者发现，在COFs的影响下，肠道微生物群的组成发生了变化，进一步导致色氨酸的微生物代谢产生改变，包括：色氨酸-3-乙酸和3-甲基吲哚的表达水平升高。 COFs引起IBD的机制综上所述，烹饪油烟是室内污染物的主要来源之一，先前被认为与呼吸系统疾病有关。而这项研究继续向下挖掘，研究者发现吸入的环境污染物还会对远端器官产生影响，即COFs会诱导IBD相关的基因表达增加，而这些改变受到肠道菌群的影响并进一步导致色氨酸代谢发生改变。因此，你以为闻着很香的“烟火气”，本质上却是健康刺客——不仅会损害肺部健康，还可能会进一步产生全身影响。但人是铁饭是钢，做饭总归是要做的，最好的办法就是“做饭时保证良好的通风”。先前Science子刊上的研究推荐：在做饭时一定要打开厨房里窗户，保持良好的通风，同时将抽油烟机开到最大功率，或能在更短的时间内降低NO2、苯以及烹饪油烟中其他有害物的浓度。参考资料： [1]Bhurosy T, Marium A, Karaye IM, Chung T. Where there are fumes, there may be lung cancer: a systematic review on the association between exposure to cooking fumes and the risk of lung cancer in never-smokers. Cancer Causes Control. 2023 Jun;34(6):509-520. doi: 10.1007/s10552-023-01686-y. Epub 2023 Apr 8. PMID: 37031313. [2]卜云峰,蓝式贤.烹饪油烟对人体健康危害研究[J].中国食品工业,2022(12):112-114+119. [3]Liu B, Wang G, Wang L, Yan J, Zhu K, Liu Q, Zhao J, Jia B, Fang M, Rudich Y, Morawska L, Chen J. Unraveling Cross-Organ Impacts of Airborne Pollutants: A Multiomics Study on Respiratory Exposure and Gastrointestinal Health. Environ Sci Technol. 2024 Sep 3;58(35):15511-15521. doi: 10.1021/acs.est.4c06035. Epub 2024 Aug 15. PMID: 39145585. 撰文 | Swagpp 编辑 | Swagpp ● 大无语！夜班收了3个患者，欠费逃单跑了俩，共欠1万多！当事医生后续会被扣钱、写情况报告！公立医院不再收押金，如何保证就医诚信？ ● 一天8杯水？喝太多！最新研究：每日最佳饮水量找到了！能降低全因、疾病死亡率，但不能超过...... ● 震撼！坐车9小时去大三甲看病，医生下班了，睡在座椅下，副主任医师心疼加号！医生：不想被道德绑架，渴望有加号、退号和拒绝就诊的权力版权说明：梅斯医学（MedSci）是国内领先的医学科研与学术服务平台，致力于医疗质量的改进，为临床实践提供智慧、精准的决策支持，让医生与患者受益。欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。点击下方「阅读原文」立刻下载梅斯医学APP！

临床结果紧急使用授权

2024-07-20

·蒲公英Ouryao

40个品种！重点监控、超“黄线”监管名单公布 !

转自：上海阳光医药采购网编辑：水晶 7月18日，上海市医药集中招标采购事务管理所发布《关于公布2024年5月份药品挂网公开议价采购监管品种名单的通知》，公布2024年5月份挂网公开议价超“黄线”、未通过公允性评估、重点监控药品幅度靠前且有一定采购金额的品种各10个。《通知》也指出，公布品种仅作为提醒，部分品种确因成本上涨或有质量疗效优势等原因，涨幅议价；但也有部分品种价格明显高于同类在用品种。新申请超“黄线”品种合计10个：促肝细胞生长素注射液、注射用氯化钾、注射用酚磺乙胺、川芎茶调丸、奥扎格雷钠注射液、注射用天麻素、消炎利胆胶囊、冠心苏合软胶囊、丹参口服液等。原在库超“黄线”品种合计10个：注射用氢化可的松琥珀酸钠、氯化钠注射液、替米沙坦氢氯噻嗪胶囊、替米沙坦氢氯噻嗪片、注射用头孢唑肟钠、达肝素钠注射液、盐酸阿莫罗芬乳膏、复方氨基酸注射液(18AA-Ⅶ)等。未通过公允性品种合计10个：涉及注射用胶原酶、麻仁丸、冠心苏合软胶囊、保妇康凝胶、心悦胶囊、注射用盐酸丙帕他莫、蛤蚧定喘丸、参苓白术散、乳酶生片、生脉饮。 10个重点监控品种：小儿豉翘清热颗粒、利肺片、肌苷注射液、注射用盐酸罂粟碱、环磷腺苷注射液、注射用二羟丙茶碱、注射用氨苄西林钠、复方醋酸钠林格注射液、盐酸雷尼替丁注射液。

带量采购

2023-10-19

·Science Daily

Two probiotics identified as promising hypertension treatments

New findings point to 2 additional probiotics as potential treatments for high blood pressure. An estimated 40% of the global adult population have high blood pressure, or hypertension, which puts people at risk of cardiovascular disease and other dangerous health conditions. Recent studies suggest that probiotics may offer a protective effect, but researchers have a limited understanding of why shaping the gut microbiota can regulate blood pressure. A study published this week in mSystems adds 2 new strains to the list of potential antihypertensive probiotics. In experiments on hypertensive mice, treatment with the 2 probiotics, Bifidobacterium lactis and Lactobacillus rhamnosus, returned blood pressure to normal levels. The researchers also tracked how those probiotics altered the animals' gut microbial mix over 16 weeks, identifying specific microbes and metabolic pathways that may help explain the protective effect. "Accumulated evidence supports an antihypertensive effect of probiotics and probiotic fermented foods in both in vitro and in vivo experiments," said computational biologist Jun Li, Ph.D., at the City University of Hong Kong. Her team worked with that of microbiologist Zhihong Sun, Ph.D., at Inner Mongolia Agricultural University, on the study. "So we believed that the dietary intake of probiotic foods would well supplement traditional hypertension treatment." Previous studies have connected the rising rates of hypertension worldwide to increasing consumption of sugar. It likely boosts blood pressure through many mechanisms -- increased insulin resistance or salt retention, for example -- but in recent years researchers have investigated sugar's effect on the gut microbiome, as well. In the new study, the researchers tested the 2 probiotic strains on mice that developed high blood pressure after consuming water mixed with fructose. Over 16 weeks, they measured the animals' blood pressures every 4 weeks. They found that fructose-fed mice that received either probiotic showed significantly lower blood pressures than those fed a high fructose diet and not treated with probiotics. In addition, the researchers found no difference between the blood pressure readings of fructose-fed mice that received probiotics and a control group of mice that only drank water. That suggests probiotic interventions would maintain blood pressure at normal levels, Li said. The researchers used shotgun metagenomic sequencing to probe connections between the altered gut microbiota and the change in blood pressure. They found that a high-fructose diet in the mice led to an increase in Bacteroidetes and a decrease in Firmicutes bacteria; however, treatment with probiotics returned those populations to those found in the control group. In addition, the analysis identified new microbial signatures associated with blood pressure: Increased levels of Lawsonia and Pyrolobus bacteria, and reduced levels of Alistipes and Alloprevotella, were associated with lower blood pressure. The researchers are now planning a large clinical trial to see if the protective effect of probiotics extend to people with hypertension. "Probiotics present a promising avenue in preventive medicine," Sun said, "offering potential in regulating hypertension and reshaping our approach to cardiovascular health."

微生物疗法

100 项与 Bifidobacterium(Biofermin Pharmaceutical Co., Ltd.) 相关的药物交易

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适应症	国家/地区	公司	日期
菌群失调	日本	Biofermin Pharmaceutical Co., Ltd.	1955-11-19

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


Pubmed \| Pediatr Int	N/A	-	-	Bifidobacterium (Group E)	觸簾築顧衊淵範憲鑰鬱(壓糧糧網積艱膚繭網願) = 繭鏇鑰鏇艱觸遞襯壓膚膚願鹹膚襯鏇糧膚製憲 (觸網積獵築鏇繭顧鬱鹽 ) 更多	积极	2012-10-01
				Bifidobacterium (Group L)	觸簾築顧衊淵範憲鑰鬱(壓糧糧網積艱膚繭網願) = 窪齋簾顧鹹窪繭糧襯襯膚願鹹膚襯鏇糧膚製憲 (觸網積獵築鏇繭顧鬱鹽 ) 更多