更新于：2024-11-21

Kitasamycin Tartrate

酒石酸吉他霉素

更新于：2024-11-21

概要

概要

基本信息

药物类型

小分子化药

别名

Kitasamycin tartrate (JP17)、Leucomycin tartrate

靶点

50S subunit

作用机制

50S subunit抑制剂(50S核糖体亚基抑制剂)

治疗领域

感染呼吸系统疾病皮肤和肌肉骨骼疾病+ [2]

在研适应症

寻常痤疮白喉淋病+ [3]

非在研适应症-

原研机构-

在研机构-

非在研机构-

最高研发阶段批准上市

首次获批日期

中国 (1984-01-01),

寻常痤疮白喉淋病+ [3]

最高研发阶段(中国)批准上市

特殊审评-

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关联

100 项与酒石酸吉他霉素相关的临床结果

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100 项与酒石酸吉他霉素相关的转化医学

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100 项与酒石酸吉他霉素相关的专利（医药）

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项与酒石酸吉他霉素相关的文献（医药）

1979-09-01·Research in Veterinary Science3区 · 农林科学

In vitro sensitivities to antimicrobial drugs of Ureaplasmas isolated from the bovine respiratory tract, genital tract and eye

3区 · 农林科学

Article

作者: M. Kishima ; K. Hashimoto

The sensitivity to 18 antimicrobial drugs was examined for 66 strains of Ureaplasma sp isolated from respiratory tracts of calves suffering from enzootic pneumonia, urinary tracts of bulls and eyes of cows suffering from infectious bovine kerato-conjunctivitis. Furamizole, tiamulin fumarate, erythromycin lactobionate, malidomycin C, doxycycline hydrochloride, kitasamycin tartrate, tylosin tartrate, T-2636C, tetracycline hydrochloride, oxytetracycline hydrochloride, chlortetracycline hydrochloride, oleandomycin phosphate, furazolidone, spiramycin adipate, chloramphenicol and thiophenicol showed strong inhibiting activity on all the test strains. Among them, furamizole, tiamulin fumarate and erythromycin lactobionate were most active. Kanamycin sulphate showed weak activity on all the strains tested. The differences in origin of the test strains did not affect their sensitivity to any of the drugs.

1978-01-01·National Institute of Animal Health quarterly

Sensitivites in vitro to antimicrobial drugs of bovine mycoplasmas isolated from respiratory and genital tracts.

Article

作者: Kishima, M ; Hashimoto, K ; Minato, H

A total of 155 Mycoplasma strains were examined for sensitivity to nine antibiotics and four nitrofurans by the agar dilution method. They consisted of 69 strains of Mycoplasma bovirhinis, 33 strains of M. bovigenitalium, 49 strains of Acholeplasma laidlawii and four strains of A. modicum isolated from the nasal secretions, tracheas and lungs of calves manifesting respiratory symptoms and from bovine genital tracts collected at a slaughterhouse. As a result, furamizole and mitomycin C showed the strongest growth-inhibiting effect on all the strains. They were followed in this effect by kitasamycin tartrate, spiramycin adipate, tylosin tartrate, tetracycline-HCl and chloramphenicol. Furthermore, these five drugs were followed in the effect by furazolidone, nitrofurantoin and sodium nifurstyrenate. Fradiomycin sulfate and kanamycin sulfate showed only little effect on all the strains. Erythromycin lactobionate showed a strong growth-inhibiting effect on the Acholeplasma strains, but not on the Mycoplasma strains. There were some cross resistant strains of the Acholeplasma species to the effects of the macrolides.

1974-01-01·The Journal of Antibiotics4区 · 医学

in vitro ACTIVITY OF KITASAMYCIN AGAINST GRAM-POSITIVE COCCI

4区 · 医学

Article

作者: Gerald P. Bodey ; Yvonne Balducci

All Streptococcus pyogenes and Diplococcus pneumoniae strains tested in vitro were inhibited by 0.39 and 1.56 μg kitasamycin tartrate [37280-56-1]/ml, resp.; 98% of penicillin G sensitive and 99% of penicillin G resistant Staphylococcus aureus strains were inhibited by the higher concentrationMinocycline [10118-90-8], cephalothin [153-61-7], erythromycin [114-07-8], clindamycin [18323-44-9], and dicloxacillin [3116-76-5] were as active or more active than kitasamycin against gram-pos. cocci.

100 项与酒石酸吉他霉素相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D02000	-	-	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
寻常痤疮	中国	-	1984-01-01
白喉	中国	-	1984-01-01
淋病	中国	-	1984-01-01
军团病	中国	-	1984-01-01
猩红热	中国	-	1984-01-01
百日咳	中国	-	1984-01-01