Monotherapy With Piperacillin-tazobactam Versus Combination Therapy With Piperacillin-tazobactam Plus Glycopeptide as an Initial Empiric Therapy for Fever in Neutropenic Patients. An Observational Prospective Study.

The aim of this study is to compare the efficacy and tolerance of piperacillin-tazobactam versus piperacillin-tazobactam plus glycopeptide as initial empiric antibiotic treatment for fever in neutropenic patients. Study of consecutive cohorts(2). First the patients will be included in the monotherapy branch until completing the predicted number of cases. When this happens, the Coordinating Center will communicate it to the participant centers and from then the patients will be included in the combined therapy.

开始日期2001-07-01

申办/合作机构

Wyeth AB

100 项与 Glycopeptide (ProtoKinetix) 相关的临床结果

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100 项与 Glycopeptide (ProtoKinetix) 相关的转化医学

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100 项与 Glycopeptide (ProtoKinetix) 相关的专利（医药）

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2,582

项与 Glycopeptide (ProtoKinetix) 相关的文献（医药）

2025-01-01·Antonie van Leeuwenhoek

Characterization of meningitis-causing bacteria, with focus on genomic and pangenomic study of multi-drug resistant Streptococcus pneumoniae from cerebrospinal fluid

Article

作者: Irfan, Muhammad ; Al-Regaiey, Khalid ; Kori, Junaid Ahmed ; Al Abduljabbar, Danah ; Bashir, Shahid ; Rashid, Yasmeen ; Ali, Kashif ; Aurongzeb, Muhammad ; Ali, Rehan ; Kaleem, Imdad

Streptococcus pneumoniae is a major cause of meningitis in under developed countries with low vaccination rates and high antibiotic resistance. This study aimed to analyze 83 suspected meningitis patients in Karachi for the detection of S. pneumoniae followed by its whole genome sequencing and Pan Genome analysis. Out of the 83 samples collected, 33 samples with altered physical (turbidity), cytological (white blood cell count) and biochemical (total protein and total glucose concentrations) parameters indicated potential meningitis cases, while these parameters were within normal healthy ranges in remaining 50 samples. Latex particle agglutination (LPA) was performed on the 33 samples, revealing 20 positive cases of bacterial meningitis. The PCR and culturing methods revealed 5 S. pneumoniae isolates. Antibiotic susceptibility tests showed that one S. pneumoniae strain was resistant to erythromycin, levofloxacin, and tetracycline. Whole-genome sequencing of this resistant strain was performed and S. pneumoniae was confirmed with MLST analysis, while it had > 2.3 Mb genome and a single repUS43 plasmid. In CARD analysis, the strain had tet(M), ermB, RlmA(II), patB, pmrA, and patA ARGs, which could provide resistance against tetracycline, macrolide, fluoroquinolone, and glycopeptide antibiotics. Phylogenetic analysis revealed that the isolate was closely related to strains from Hungary and the USA. Pan-genome analysis with 144 genome assemblies from NCBI database showed that 1101 non-redundant core genes were shared between all strains. This study gives valuable understanding into the prevalence and characterization of meningitis-causing bacteria in Karachi, Pakistan with prime focus on multi-drug resistant S. pneumoniae.

2024-12-01·Journal of Hazardous Materials

Embryonic exposure to glycopeptides induces acute toxicity and developmental neurotoxicity in zebrafish (Danio rerio)

Article

作者: Ma, Xinyan ; Wang, Hao ; Zhang, Jingpu ; Du, Jiyang ; Zhang, Rui ; Liu, Kehui ; Hu, Haicheng ; Yu, Liyan ; Ma, Yuanyuan ; Han, Ying

Glycopeptide antibiotics are crucial in combating severe bacterial infections. However, concerns persist regarding their environmental impact and potential toxicity to human health. This study explores the dose-dependent toxicity of glycopeptide antibiotics on zebrafish embryos, revealing significant differences in developmental and neurological effects. Our findings indicate that oritavancin (ORI) and telavancin (TEL) exhibit greater acute toxicity compared to vancomycin (VAN). High doses of glycopeptides cause notable developmental abnormalities, including reduced body length and potential organ formation disruptions. TEL's prominent accumulation in embryos likely contributes to its heightened toxicity. The study also highlights differential effects on zebrafish locomotion, with ORI affecting sensory processing and motor control, TEL altering swimming time distribution, and VAN influencing inactivity and active swimming, varying by concentration and light-dark cycles. Molecular analyses, including RNA-seq and qRT-PCR, show that glycopeptides significantly alter gene expression related to nervous system development, particularly affecting sipa1l1, a gene essential for synaptic function and dendritic spine growth. The disruption of neurodevelopmental pathways suggests mechanisms through which these compounds influence development. These findings underscore the critical role of glycopeptide structure in toxicity and emphasize the need for further research to delineate specific affected molecular pathways, which could guide future studies and treatments for neurodevelopmental disorders.

2024-12-01·Therapeutic Drug Monitoring

A Retrospective Study Evaluating Neonatal Vancomycin Loading Doses to Achieve a Therapeutic Target

Article

作者: van Eck, Andrew ; Dramowski, Angela ; Reddy, Kessendri ; Bekker, Adrie ; Decloedt, Eric H. ; Fataar, Aaqilah ; Pillay-Fuentes Lorente, Veshni

Background:Vancomycin is a glycopeptide antibiotic that has been used to treat hospital-acquired gram-positive infections for more than 5 decades. However, the literature is divided regarding the therapeutic advantages of vancomycin loading doses in neonates.Objectives:This study aimed to investigate the effect of vancomycin loading doses on therapeutic target attainment in neonates with sepsis.Methods:A retrospective cohort study was conducted to compare the vancomycin target attainment (area under the curve 0–24 hours/minimum inhibitory concentration ≥400) in neonates before and after the 2019 change in vancomycin prescription guidelines at a neonatal unit in Cape Town, South Africa. As the standard of care, Bayesian modelling software was used to compute the area under the curve from the trough concentrations.Results:Two hundred ten neonates were included. Multivariate regression analysis showed a 2-fold increase in the odds of target attainment among neonates receiving a loading dose of vancomycin. Early target attainment (within 8–12 hours of treatment initiation) was significantly higher in the loading dose group compared with the no loading dose group [97/105 (92.4%) versus 64/105 (61.0%); P < 0.001]. However, the overall proportion of neonates achieving target attainment at 24 hours was similar between groups [73/105 (69.5%) in the loading dose group versus 62/105 (59.0%) in the no loading dose group; P = 0.110]. The nephrotoxicity rates were low [2/105 (1.9%) in the loading dose group and 2/105 (1.9%) in the no loading dose group].Conclusions:The addition of a vancomycin loading dose to neonates may facilitate early therapeutic target attainment.

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