A preparation of CimertrA, comprising Artemisinin, Curcumin, and Boswellia, and Vitamin C in a nanoparticular formulation, is proposed as a treatment for the disease associated with the novel coronavirus SARS-CoV-2. This initiative is presented under the urgent circumstances of the fulminant pandemic caused by this lethal disease, which is known as COVID-19 and has spread across the globe causing death and disrupting the normal function of modern society. The grounds for the proposal are rooted in existing knowledge on the components and pharmacological features of this formulation and their relevance to the current understanding of the disease process being addressed.
The severe acute respiratory syndrome-associated coronavirus disease 2019 (COVID-19) illness results from the immediate response to the viral infection as well as from a subsequent host inflammatory response. Systemic proinflammatory cytokines and biomarkers are elevated as the disease progresses towards its advanced stages, and correlate with worse chances of survival.
Serum cytokine levels that are elevated in patients with Covid-19-associated cytokine storm include interleukin-1β, interleukin-6, IP-10, TNF, interferon-γ, macrophage inflammatory protein (MIP) 1α and 1β, and VEGF. Higher interleukin-6 levels are strongly associated with shorter survival. The relative frequencies of circulating activated CD4+ and CD8+ T cells and plasmablasts are increased in Covid-19. In addition to the elevated systemic cytokine levels and activated immune cells, several clinical and laboratory abnormalities, such as elevated CRP and d-dimer levels, hypoalbuminemia, renal dysfunction, and effusions, are also observed in Covid-19. Laboratory test results reflecting hyper inflammation and tissue damage were found to predict worsening outcomes in Covid-19.
CimetrA, comprising Artemisinin, Curcumin, Boswellia, and Vitamin C in a nanoparticular formulation, has been studied on patients with COVID-19 in a randomized double-blind control Phase II study (MGC-006 - under a previous product name - ArtemiC). The study product demonstrated excellent safety and efficacy profiles.
Experiments performed in vitro with CimetrA demonstrated the ability to reduce cytokine elevation in response to stimulation of human PBMC preparations.
The currently proposed Multi-center multinational-controlled study is designed to include 252 adult patients who suffer from moderate COVID-19 infection. Safety will be assessed through collection and analysis of adverse events, blood and urine laboratory assessments, and vital signs.
After the screening visit, the study drug will be administrated twice a day morning and evening (every 12 hours) during (day 1 and day 2) The patients will be randomized in 1:1:1 ratio to study drug (CimetrA) in addition to Standard of Care (Arm 1 (CimetrA-1) or Arm 2 (CimetrA-2)) or Placebo in addition to Standard of Care (Arm 3).

开始日期2021-06-11

申办/合作机构

MGC Pharmaceuticals d.o.o

100 项与 CimetrA 相关的临床结果

登录后查看更多信息

100 项与 CimetrA 相关的转化医学

登录后查看更多信息

100 项与 CimetrA 相关的专利（医药）

登录后查看更多信息

项与 CimetrA 相关的新闻（医药）

2024-02-13

·PRNewswire

MGC Pharma Rebrands as Argent BioPharma in Strategic Transformation

Embracing Comprehensive Restructuring for a New Biopharmaceutical Era Continuing the Development of MGC Pharma's Innovative Drug Portfolio LONDON, Feb. 13, 2024 /PRNewswire/ -- MGC Pharmaceuticals Ltd (LSE: MXC), (OTC: MGCLF), (ASX: MXC) Rebrands as Argent BioPharma in Strategic Transformation Marking a significant milestone in its evolutionary journey, MGC Pharma has officially announced its rebranding to Argent BioPharma, pending approval from its shareholders. This rebranding is the culmination of an extensive restructuring, incorporating significant American capital and operational revisions. Poised for growth, Argent BioPharma is now set to emerge as a key player in the biopharmaceutical industry, leveraging cutting-edge advancements in Polypharmacology and Nanotechnology. With its presence on both the London Stock Exchange and the Australian Stock Exchange, Argent BioPharma is well-positioned to make substantial contributions to enhancing medical treatment accessibility. Embracing Comprehensive Restructuring for a New Biopharmaceutical Era Innovating with Polypharmacology At the core of Argent BioPharma's strategy is Polypharmacology, a revolutionary approach that involves the creation of therapies targeting multiple molecular targets. This strategy is instrumental in addressing complex multifactorial diseases, setting new benchmarks in drug development and therapeutic outcomes. Strategic Operational Focus Argent BioPharma is strategically focusing on generating revenue through its Investigational Medicinal Products (IMP), available to patients in major markets like the UK, USA, and Europe through early access schemes. This strategy is bolstered by invaluable real-world data gathered from these early access treatments, enhancing the safety and efficacy profiles of their clinical trials. The company's European research and development center is a beacon of innovation, playing a crucial role in the entire drug development process, from initial concept to market launch. With two specialized manufacturing sites, Argent BioPharma adheres to the strict EU GMP and GDP guidelines, ensuring high-quality production standards. Continuing the Development of MGC Pharma's Innovative Drug Portfolio A Future-Oriented Product Line Argent BioPharma is dedicated to advancing its product portfolio, which focuses on immunology and neurology, employing Polypharmacology to develop novel treatments. Committed to introducing new treatment options every four years, the company aims to meet urgent unmet medical needs. Its leading products, including CannEpil® for refractory epilepsy and cerebral palsy, CimetrA® for acute lung injury and ARDS, and CogniCann® for dementia and Alzheimer's disease, exemplify its commitment to innovation and patient care. Vision, Mission, and Strategic Objectives Argent BioPharma is driven by a vision to become a globally recognized leader in the biopharmaceutical industry, committed to addressing unmet medical needs through the integration of Polypharmacology and Nanotechnology. Its mission is centered on researching and developing innovative treatments for global health challenges, guided by its strategic pillars of pioneering life science innovations, ensuring global accessibility, fostering consistent innovation, and achieving industry leadership. Upholding Core Values and Governance Argent BioPharma not only pledges to advance healthcare through innovative R&D but also upholds a collaborative and ethical research culture. The company's operations are rooted in core values of integrity, diversity, teamwork, accountability, and excellence, all supported by a strong foundation in Environmental, Social, and Governance principles. As Argent BioPharma transitions from MGC Pharma, it stands ready to lead a new era in biopharmaceuticals, promising accessible and impactful healthcare solutions on a global scale. Contact: UK IR/PR Advisers IFC Advisory Graham Herring / Tim Metcalfe / Zach Cohen +44 203 934 6630 [email protected] MGC Pharmaceuticals Ltd Rowan Harland Company Secretary +61 8 6382 3390 [email protected] Logo - SOURCE MGC Pharmaceuticals Ltd

100 项与 CimetrA 相关的药物交易

登录后查看更多信息