ML142(ML142) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点-

作用方式-

作用机制-

治疗领域

感染神经系统疾病其他疾病

在研适应症-

非在研适应症

西尼罗河热

原研机构

Southern Research Institute

在研机构-

非在研机构

Southern Research Institute

权益机构-

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 ML142 相关的临床结果

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100 项与 ML142 相关的转化医学

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100 项与 ML142 相关的专利（医药）

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1

项与 ML142 相关的文献（医药）

A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activity Against West Nile Virus

作者: Lynn Rasmussen ; E Lucile White ; Marintha Heil ; Shuang Feng ; DongHoon Chung ; Thomas Dy Chung ; Santhi Reddy Ganji ; Shakeela Dad ; Clinton Maddox ; Subramaniam Ananthan ; Sara N McKellip ; Nichole A Tower ; Fuli Jia ; Blake P Moore ; Robert Ardecky ; Colleen B Jonsson ; Ying Su ; Nicholas Dp Cosford

West Nile Virus (WNV) is a mosquito-borne pathogen that causes febrile illness and, occasionally, encephalitis when transmitted to humans. Infection can cause significant health problems such as West Nile fever and neuroinvasive disease. The goal of the assay was to identify and develop chemical probes that inhibit in vitro replication of WNV. An unbiased phenotypic whole virus cell-based assay was utilized to select chemical probes that inhibit WNV propagation without adversely affecting the host cell. The two probe candidates described in this report, ML143 (CID-2557019) and ML142 (CID-928277), provide two small molecules that demonstrate modest yet useful potency against the West Nile Virus, but with a robust margin of selectivity against cell cytotoxicity, providing potentially useful evaluation tools for small animal toxicity and efficacy studies.

100 项与 ML142 相关的药物交易

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