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更新于：2025-03-20

Dibucaine Hydrochloride/Sodium Salicylate/Calcium Bromide

盐酸辛可卡因/水杨酸钠/溴化钙

更新于：2025-03-20

概要

基本信息

药物类型

小分子化药

别名

Dibcalsor、Dikabelin、Neo Vitacain

+ [5]

靶点

COXs x Nav1.5 x Nav1.8

作用方式

抑制剂、阻滞剂

作用机制

COX抑制剂(环氧化酶抑制剂)、Nav1.5阻滞剂(V型钠通道蛋白α亚基阻滞剂)、Nav1.8阻滞剂(X型钠通道蛋白α亚基阻滞剂)

治疗领域

神经系统疾病皮肤和肌肉骨骼疾病

在研适应症

关节周围炎腰痛肌痛+ [2]

非在研适应症-

原研机构

Vitacain Pharmaceutical Co. Ltd.

在研机构

Shiono Chemical Co. Ltd.NISSIN Pharmaceutical Co., Ltd.Nichi-Iko Gifu Plant Co., Ltd.

+ [1]

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1959-08-06),

腰痛肌痛神经痛+ [1]

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C27H36Br2CaClN3NaO5

InChIKeySXSMEDSFMLZVDK-UHFFFAOYSA-L

CAS号206115-89-1

关联

100 项与盐酸辛可卡因/水杨酸钠/溴化钙相关的临床结果

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100 项与盐酸辛可卡因/水杨酸钠/溴化钙相关的转化医学

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100 项与盐酸辛可卡因/水杨酸钠/溴化钙相关的专利（医药）

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项与盐酸辛可卡因/水杨酸钠/溴化钙相关的文献（医药）

Stomatologia

Klinika apoteles mata me te chress tou Neo-Lidocaton.

Article

作者: Laurentiades, I G

Oyo Yakuri

The significance of prescription in an injection solution containing dibucaine hydrochloride as basis (Neo Vitacain)

作者: Komatsu, Hirotsugu ; Ishikawa, Hatsuyo ; Imayoshi, Tomonori ; Karasawa, Katsuhiro ; Yasunaga, Yukihiro

Neo Vitacain Injection containing 0.1% dibucaine hydrochloride (D), 0.3% sodium salicylate (S) and 0.2% calcium bromide (B) is a widely used analgesic preparation in the fields of anesthesiol. and orthopedics.Regarding the significance of the prescription of this drug. inconsistent results were obtained in non-clin. studies.In this study, we investigated the influences of S and/or B on the local anesthetic effect of D using the infiltration anesthesia test model in guinea pigs.ED₅₀ values were estimated as the concentration of D in D alone and in combination (D+S, D+B and D+S+B).Using these ED₅₀ values, the potency ratios were calculatedAs for the significance of combination with S, the potency ratio between D+S+B and D alone was 2.00 [95% confidence limit (CL); 1.29-3.09, 40 min after treatment], and that between D + S and D alone was 1.67 [CL; 1.11-2.44, 25 min].Moreover, in both cases the durations of infiltration anesthetic effect were prolonged.As for the significance of combination with B, the potency ratio between D+B and D alone was 0.90-1.10 [1.10 (CL; 0.63-2.04, 20 min), 1.00 (CL; 0.66-1.52, 25 min) and 0.90 (CL; 0.53-1.53, 30 min)], and that between D+S+B and D+S was 1.20 [CL; 0.73-2.13, 20 min].In conclusion, the local anesthetic potency of D by S was enhanced in this study.This enhancement is considered to be due by the increased intracellular concentration of ionized D (active form) to S through the acidification of the intracellular pH.As for B, further studies are required to clarify the effectiveness of this preparation

European Journal of Biomedical and Pharmaceutical Sciences

Effects of neo VitacainTM in stellate ganglion block

作者: Nishiyama, Tomoki

The purpose of this study was to compare prospectively the effects of Neo VitacainTM (dibucaine 5 mg (0.1%), sodium salicylate 15 mg (0.3%), and calcium bromide (0.2%)) with local anesthetics in stellate ganglion block (SGB).Thirty patients scheduled for stellate ganglion block for post herpetic neuralgia were enrolled.Fifteen patients received SGB with Neo VitacainTM 5 mL for the first 5 times, then changed to the SGB with 1% lidocaine 5 mL for the next 5 times.Another 15 patients received SGB with 1% lidocaine 5 mL for the first 5 times, then changed to the SGB with Neo VitacainTM 5 mL for the next 5 times.Blood pressure, heart rate, pain as accessed by the visual analog scale (VAS, 0 - 100) and appearance of Horner syndrome and hoarseness were compared between lidocaine and Neo VitacainTM.Blood pressure and heart rate did not change significantly with both Neo VitacainTM and lidocaine.VAS score decreased without any differences between Neo VitacainTM and lidocaine.The number of the Horner sign was smaller with Neo VitacainTM, but not statistically significant.The number of the hoarseness was significantly lower with Neo VitacainTM than lidocaine In conclusion, SGB with Neo VitacainTM and lidocaine showed similar analgesic effects on post herpetic neuralgia and Neo VitacainTM induced less hoarseness than lidocaine.

100 项与盐酸辛可卡因/水杨酸钠/溴化钙相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
关节周围炎	日本	NISSIN Pharmaceutical Co., Ltd.	1997-01-31
腰痛	日本	Vitacain Pharmaceutical Co. Ltd.	1959-08-06
肌痛	日本	Vitacain Pharmaceutical Co. Ltd.	1959-08-06
神经痛	日本	Vitacain Pharmaceutical Co. Ltd.	1959-08-06
肩关节周围炎	日本	Vitacain Pharmaceutical Co. Ltd.	1959-08-06