Synthesis, absolute configuration, conformational analysis and binding affinity properties of enantiomeric forms of DAU 5750, a novel M1–M3 muscarinic receptor antagonist
3区 · 医学
Article
作者: Giovanbattista Schiavi ; Marco Turconi ; Giovanni Fronza ; Pierfrancesco Bravo ; Andrea Gozzo ; Andrea Mele
Both the enantiomeric forms of DAU 5750, a novel muscarinic receptor antagonist, have been synthesized in order to assess the relevance of configurational/conformational features for high affinity binding to muscarinic receptor subtypes. The attribution of absolute stereochemistry and conformational analysis by means of molecular modelling and NMR techniques are also reported.