RNA tumor vaccine(First Affiliated Hospital Bengbu Medical College)(RNA tumor vaccine(First Affiliated Hospital Bengbu Medical College))

概要

基本信息

药物类型

通用抗原疫苗、治疗性疫苗、mRNA疫苗

别名-

靶点

KRAS

作用机制

KRAS调节剂(KRAS蛋白调节剂)、免疫刺激剂

治疗领域

肿瘤

在研适应症-

非在研适应症

晚期恶性实体瘤

原研机构

蚌埠医学院第一附属医院（蚌埠医学院附属肿瘤医院）

在研机构-

非在研机构

蚌埠医学院第一附属医院（蚌埠医学院附属肿瘤医院）

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)无进展

特殊审评-

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关联

2

项与 RNA tumor vaccine(First Affiliated Hospital Bengbu Medical College) 相关的临床试验

NCT05202561 / Unknown status临床1期IIT

A Single-Arm, Open-Label, Exploratory Study to Evaluate the Safety of RNA Tumor Vaccine Injection Alone/in Combination With PD-1 Inhibitor in the Treatment of Advanced Solid Tumors With KRAS Mutation

This is a single-arm, open-label, clinical pharmacology study to evaluate the safety of RNA tumor vaccine injection alone/in combination with PD-1 inhibitor in the treatment of advanced solid tumors with KRAS mutation.
The purpose of this study is to evaluate the safety and tolerability, antitumor activity, The immunoreactivity, pharmacokinetics and of RNA tumor vaccine.

开始日期2022-03-10

申办/合作机构

蚌埠医学院第一附属医院（蚌埠医学院附属肿瘤医院）

ChiCTR2200056172 / Recruiting临床1期IIT

A clinical pharmacological exploration study of single-arm, open RNA tumor vaccine injection in combination with PD-1 inhibitor in the treatment of advanced solid tumors with KRAS mutation

开始日期2022-01-21

申办/合作机构

蚌埠医学院第一附属医院（蚌埠医学院附属肿瘤医院）

100 项与 RNA tumor vaccine(First Affiliated Hospital Bengbu Medical College) 相关的临床结果

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100 项与 RNA tumor vaccine(First Affiliated Hospital Bengbu Medical College) 相关的转化医学

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100 项与 RNA tumor vaccine(First Affiliated Hospital Bengbu Medical College) 相关的专利（医药）

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371

项与 RNA tumor vaccine(First Affiliated Hospital Bengbu Medical College) 相关的文献（医药）

2024-07-01·Small

Photodynamic Therapy Derived Personalized Whole Cell Tumor Vaccine Prevents Postsurgery Tumor Recurrence and Metastasis

Article

作者: Zhu, Xianqi ; Jiang, Yitong ; Zhang, Kaixin ; Yu, Qingsong ; Chen, Jiawei ; Gan, Zhihua ; Yu, Haiwang ; Yang, Chunyu ; Gu, Xinggui ; Li, Jianlin

AbstractIn order to avoid the time‐consuming and laborious identification of tumor‐specific antigens (TSAs) during the traditional vaccine fabrication process, a versatile photodynamic therapy (PDT)‐based method is developed to construct a whole‐tumor antigen tumor vaccine (TV) from surgically resected tumor tissues for personalized immunotherapy. Mucoadhesive nanoparticles containing small‐molecular photosensitizer are fabricated and directly co‐incubated with suspended tumor cells obtained after cytoreduction surgery. After irradiation with a 405 nm laser, potent immunogenic cell death of cancer cells could be induced. Along with the release of TSAs, the as‐prepared TV could activate safe and robust tumor‐specific immune responses, leading to efficient suppression of postsurgery tumor recurrence and metastasis. The as‐prepared TV cannot only be applied alone through various administration routes but also synergize with immunoadjuvant, chemotherapeutics, and immune checkpoint blockers to exert more potent immune responses. This work provides an alternative way to promote the clinical translation of PDT, which is generally restricted by the limited penetration of light. Moreover, the versatile strategy of vaccine fabrication also facilitates the clinical application of personalized whole‐cell tumor vaccines.

2024-04-01·Cellular Oncology

From basic research to clinical application: targeting fibroblast activation protein for cancer diagnosis and treatment

Review

作者: Cao, Zhe ; Xiao, Jianchun ; Zhang, Taiping ; Zhang, Zeyu ; Tao, Jinxin ; Qiu, Jiangdong ; Huang, Hua

PURPOSEThis study aims to review the multifaceted roles of a membrane protein named Fibroblast Activation Protein (FAP) expressed in tumor tissue, including its molecular functionalities, regulatory mechanisms governing its expression, prognostic significance, and its crucial role in cancer diagnosis and treatment.METHODSArticles that have uncovered the regulatory role of FAP in tumor, as well as its potential utility within clinical realms, spanning diagnosis to therapeutic intervention has been screened for a comprehensive review.RESULTSOur review reveals that FAP plays a pivotal role in solid tumor progression by undertaking a multitude of enzymatic and nonenzymatic roles within the tumor stroma. The exclusive presence of FAP within tumor tissues highlights its potential as a diagnostic marker and therapeutic target. The review also emphasizes the prognostic significance of FAP in predicting tumor progression and patient outcomes. Furthermore, the emerging strategies involving FAPI inhibitor (FAPI) in cancer research and clinical trials for PET/CT diagnosis are discussed. And targeted therapy utilizing FAP including FAPI, chimeric antigen receptor (CAR) T cell therapy, tumor vaccine, antibody-drug conjugates, bispecific T-cell engagers, FAP cleavable prodrugs, and drug delivery system are also introduced.CONCLUSIONFAP's intricate interactions with tumor cells and the tumor microenvironment make it a promising target for diagnosis and treatment. Promising strategies such as FAPI offer potential avenues for accurate tumor diagnosis, while multiple therapeutic strategies highlight the prospects of FAP targeting treatments which needs further clinical evaluation.

2023-12-15·Human Vaccines & Immunotherapeutics

Tumor vaccines: Toward multidimensional anti-tumor therapies

Review

作者: Fan, Qiuying ; Chen, Huiyuan ; Chen, Juanjuan ; Tan, Yuanfang ; Gou, Xi

For decades, immunotherapies have offered hope for patients with advanced cancer. However, they show distinct benefits and limited clinical effects. Tumor vaccines have the potential to prime tumor-antigen-specific T cells and induce broad subsets of immune responses, ultimately eradicating tumor cells. Here, we classify tumor vaccines by their anti-tumor mechanisms, which include boosting the immune system, overcoming tumor immunosuppression, and modulating tumor angiogenesis. We focus on multidimensional tumor vaccine strategies using combinations of two or three of the above mechanisms, as these are superior to single-dimensional treatments. This review offers a perspective on tumor vaccine strategies and the future role of vaccine therapies in cancer treatment.

100 项与 RNA tumor vaccine(First Affiliated Hospital Bengbu Medical College) 相关的药物交易

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