植物鞘氨醇(Phytosphingosine hydrochloride)

概要

基本信息

药物类型

小分子化药

别名

(+)-D-ribo-phytosphingosine、4-D-Hydroxysphinganine、4-R-hydroxyoctadecasphinganine

+ [3]

靶点-

作用方式-

作用机制-

治疗领域

其他疾病

在研适应症-

非在研适应症

溃疡

原研机构

1 A Pharma GmbH

在研机构-

非在研机构

1 A Pharma GmbH

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构/序列

分子式C18H40ClNO3

InChIKeyGDKAAHDFPOWGQE-RXQQAGQTSA-N

CAS号154801-32-8

查看全部结构式(2)

关联

3

项与植物鞘氨醇相关的临床试验

RBR-7rmtzg

/ CompletedN/AIIT

Effect of phytosphingosine associated with toothbrushing regarding color alteration, surface roughness and microhardness of dental enamel - an in vitro and in situ study.

开始日期2020-01-06

申办/合作机构-

NL-OMON25165

/ CompletedN/AIIT

A phase I/II, double blind, cross-over design, placebo controlled, pilot study to assess the effect and tolerability of multiple oral doses of phytosphingosine in Sjögren’s patients.

开始日期2009-09-01

申办/合作机构-

NL-OMON23195

/ RecruitingN/A

The effect of dietary phytosphingosine on insulin resistance and cholesterol levels in patients with the metabolic syndrome

开始日期2008-04-01

申办/合作机构-

100 项与植物鞘氨醇相关的临床结果

登录后查看更多信息

100 项与植物鞘氨醇相关的转化医学

登录后查看更多信息

100 项与植物鞘氨醇相关的专利（医药）

登录后查看更多信息

1,517

项与植物鞘氨醇相关的文献（医药）

2025-06-01·Case Studies in Chemical and Environmental Engineering

Untargeted metabolomic LC-HRMS combined with chemometric reveal metabolites change from sorghum flakes affected by food processing

作者: Suratno ; Anggraeni, Ayu Septi ; Khasanah, Yuniar ; Nurfahmi, Laely ; Alam, Lucky Prabowo Miftachul ; Windarsih, Anjar ; Noviana, Ika Mulawati Purwanti ; Utami, Indrawati Dian

A non-targeted UHPLC-HRMS metabolomics approach combined with chemometric anal. was employed to assess the change in metabolite profiles of sorghum flakes based on food processing techniques.The result showed that fatty acids were the most abundant metabolites, followed by lipids, amino acids, alkaloids, amines, and polyphenols, representing key metabolic markers influenced by food processing in sorghum flakes.Specific metabolites, including 15S-Hydroxyeicosatrienoic acid (15S-HETrE), terminaline, vitamin E acetate, furan fatty acid F6, all-trans-retinal, and fingolimod, exhibited increased concentrations during oven processing compared to raw sorghum, likely due to their thermal stability.This study provides valuable insights into effect of food processing effect on metabolites profiles.

2025-04-01·Food Chemistry

Unbiased Metabolomic and Chemometric profiles of three Sargassum polycystum extracts using GCMS and LCMS/MS: content analysis, correlation analysis and molecular docking

Article

作者: Lim, Vuanghao ; Abdulameed, Hassan Taiye ; Alallam, Batoul

Sargassum polycystum (S. polycystum) is a brown macroalga with a high phytochemical content, making it a nutritious and bioactive food source. However, information on factors contributing to health benefits, like antioxidants and cytotoxicity, is less explored for Malaysian S. polycystum. In this study, three extracts of S. polycystum were characterized using a combination of analytical techniques. Despite similar carbohydrate content across all extracts, water extract exhibited the highest protein [21.90 ± 1.01 albumin equivalent (μg/mg)] and phenolic [7.73 ± 1.95 gallic acid equivalent (μg/mg)] contents. However, it displayed the lowest antioxidant and anticancer activities [half-maximal inhibitory concentration (IC₅₀) of > 2000 μg/mL]. Interestingly, ethanolic extract demonstrated the strongest scavenging activity (IC₅₀ of 397.90 ± 20.43 μg/mL) and selective anticancer activity against MCF7 breast cancer cells (IC₅₀ of 338.63 ± 48.98 μg/mL). Untargeted metabolomic profiling confirmed the differences in the chemical composition of the extracts. Subsequently, correlation and docking analyses were used to identify the potential bioactive compounds within the extracts. The ethanolic extract is a rich source of these bioactive compounds with superior antioxidant and anticancer properties, highlighting the need for further research on its potential utility in the food industry.

2025-04-01·Food Chemistry

Uncovering metabolite changes of potato Fusarium sambucinum infection based on a UPLC-Q-TOF metabonomic approach

Article

作者: Zhang, Fan ; Xie, Shiyuan ; Pan, Xinyue ; Wang, Wenxiu ; Shi, Qi ; Chen, Kexiang ; Sun, Jianfeng

Fusarium sambucinum causes dry rot disease and postharvest storage losses in potatoes. Understanding the defense mechanisms of potato plants may lead to the development of rational disease control approaches. In the present study, "Kexin one" potato variety was infected with F. sambucinum, and samples were collected at 0, 10, and 20 d post-infection and analyzed using ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry to determine metabolic differences. We identified 1049 significant differential metabolites belonging to 12 categories, including organic and amino acids and peptides, which can be biomarkers for dry rot in potatoes following F. sambucinum infection. Physiological and biochemical indicators of dry rot potatoes were explored, and the results were consistent with those of metabolomic data. The findings of this study provide a basis for the control of dry rot and prevention of postharvest losses in potatoes.

100 项与植物鞘氨醇相关的药物交易

登录后查看更多信息