植物鞘氨醇(Phytosphingosine hydrochloride)

概要

基本信息

药物类型

小分子化药

别名

(+)-D-ribo-phytosphingosine、4-D-Hydroxysphinganine、4-R-hydroxyoctadecasphinganine

+ [3]

靶点-

作用方式-

作用机制-

治疗领域

其他疾病

在研适应症-

非在研适应症

溃疡

原研机构

1 A Pharma GmbH

在研机构-

非在研机构

1 A Pharma GmbH

权益机构-

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C18H40ClNO3

InChIKeyGDKAAHDFPOWGQE-RXQQAGQTSA-N

CAS号154801-32-8

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关联

3

项与植物鞘氨醇相关的临床试验

RBR-7rmtzg

/ CompletedN/AIIT

Effect of phytosphingosine associated with toothbrushing regarding color alteration, surface roughness and microhardness of dental enamel - an in vitro and in situ study.

开始日期2020-01-06

申办/合作机构-

NL-OMON25165

/ CompletedN/AIIT

A phase I/II, double blind, cross-over design, placebo controlled, pilot study to assess the effect and tolerability of multiple oral doses of phytosphingosine in Sjögren’s patients.

开始日期2009-09-01

申办/合作机构-

NL-OMON23195

/ RecruitingN/A

The effect of dietary phytosphingosine on insulin resistance and cholesterol levels in patients with the metabolic syndrome

开始日期2008-04-01

申办/合作机构-

100 项与植物鞘氨醇相关的临床结果

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100 项与植物鞘氨醇相关的转化医学

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100 项与植物鞘氨醇相关的专利（医药）

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1,536

项与植物鞘氨醇相关的文献（医药）

2025-08-01·Food Chemistry

Investigation into the effects of acute heat stress on stress level, meat quality, myofibrillar proteins properties and serum metabolites release of Muscovy ducks (Cairina moschata)

Article

作者: Huang, Ming ; Li, Zimu ; Huang, Jichao ; Zhu, Zongshuai ; Huang, Tianran ; Xiao, Mengchao

This study systematically investigated the effects of acute heat stress (AHS) on Muscovy ducks, focusing on plasma stress indicators, meat quality, myofibrillar proteins (MPs) properties, and serum metabolite profiles. AHS significantly elevated stress level, impairing meat quality, as evidenced by higher L* value, shear force, drip loss, and cooking loss (P < 0.05). It also induced MPs oxidation and aggregation, reflected by elevated carbonyl content, turbidity, zeta potential, and particle size. MPs structural alterations were confirmed by fluorescence quenching and increased exposure of hydrophobic groups. Correlation analysis revealed strong associations between physicochemical changes and MPs oxidation. Metabolomic analysis identified 161 and 105 differential metabolites in the CON vs. LS and CON vs. SS comparisons, respectively, involving 25 metabolic pathways related to energy, amino acids, and fatty acids. These findings provide novel insights into the molecular pathways of AHS-induced meat quality deterioration and reveal potential intervention timing for the poultry industry.

2025-06-01·Case Studies in Chemical and Environmental Engineering

Untargeted metabolomic LC-HRMS combined with chemometric reveal metabolites change from sorghum flakes affected by food processing

作者: Suratno ; Anggraeni, Ayu Septi ; Khasanah, Yuniar ; Alam, Lucky Prabowo Miftachul ; Nurfahmi, Laely ; Windarsih, Anjar ; Noviana, Ika Mulawati Purwanti ; Utami, Indrawati Dian

A non-targeted UHPLC-HRMS metabolomics approach combined with chemometric anal. was employed to assess the change in metabolite profiles of sorghum flakes based on food processing techniques.The result showed that fatty acids were the most abundant metabolites, followed by lipids, amino acids, alkaloids, amines, and polyphenols, representing key metabolic markers influenced by food processing in sorghum flakes.Specific metabolites, including 15S-Hydroxyeicosatrienoic acid (15S-HETrE), terminaline, vitamin E acetate, furan fatty acid F6, all-trans-retinal, and fingolimod, exhibited increased concentrations during oven processing compared to raw sorghum, likely due to their thermal stability.This study provides valuable insights into effect of food processing effect on metabolites profiles.

2025-06-01·Food Chemistry

Investigation of the oxidation rules and oxidative stability of seabuckthorn fruit oil during storage based on lipidomics and metabolomics

Article

作者: Wan, Yilai ; Zhang, Xu ; Wang, Jing ; Wei, Changqing ; Wang, Ting ; Liu, Wenyu ; Li, Yazhuan ; Leng, Yuanyuan

Seabuckthorn fruit oil (SBFO) is recognized for its high nutritional value, yet it remains highly prone to oxidation during storage. The changes in its primary components and micronutrient molecules during storage have not been thoroughly investigated. This study employed untargeted lipidomics and metabolomics to dynamically monitor alterations in lipid composition and metabolites of SBFO over 30 days of accelerated storage. Lipidomics analysis revealed an increase in TGs and oxidized fatty acids, while sphingolipids, glycerophospholipids, and total lipid content showed significant reductions (p < 0.05). After 30 days, metabolomics combined with bioinformatics analysis identified 13 critical pathways, with linoleic acid metabolism consistently associated with SBFO oxidation. Key oxidation products included 9(S)-HpODE, 9,10,13-TriHOME, and 9,10-DHOME. This study provides potential targets for developing endogenous antioxidants in SBFO and offers new perspectives on the oxidation mechanisms of edible oils.

100 项与植物鞘氨醇相关的药物交易

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