Europium functionalized porphyrin-based metal-organic framework heterostructure and hydrogel for visual ratiometric fluorescence sensing of sulfonamides in foods

Article

作者: Zhu, Bing ; Xiang, Qisen ; Yue, Xiaoyue ; Zhu, Amei ; Bai, Yanhong ; Jie, Mingsha ; Lan, Shengkai

Protecting human health and ensuring food security require the swift and accurate detection of sulfonamides (SAs) residues in foods. Herein, we proposed an Eu-postfunctionalized bimetallic porphyrin metal-organic framework (PCN-221(Zr/Ce)@Eu-DPA-H₄btec) synthesized solvothermally for fluorescence sensing. The PCN-221(Zr/Ce)@Eu-DPA-H₄btec fluorescent sensor demonstrated excellent stability and high selectivity to SAs, and the detection limits of sulfamethazine (SM₂), sulfamerazine (SMR), and sulfamethoxydiazine (SMD) were as low as 56 nmol/L, 45 nmol/L, and 56 nmol/L, respectively. The PCN-221(Zr/Ce)@Eu-DPA-H₄btec fluorescent sensor was successfully applied for the detection of SM₂, SMR, and SMD in real pork and milk samples, with satisfactory recoveries (81.2-118.3%) and high precisions (RSDs <8.2, n = 3). Combining the optical properties of the nanohybrids, PCN-221(Zr/Ce)@Eu-DPA-H₄btec integrated fluorescent hydrogels were innovatively prepared for visual sensing of SM₂, SMR, and SMD. This study provides an uncomplicated and sensitive method for SAs detection in food matrices.

2024-09-01·The Journal of Prosthetic Dentistry

Cameo and intaglio surface stability and variability of additively, subtractively, and conventionally manufactured occlusal devices after long-term storage

Article

作者: Cakmak, Gulce ; Orgev, Ahmet ; Donmez, Mustafa Borga ; Yilmaz, Burak ; Marques, Vinicius Rizzo ; Kahveci, Cigdem ; Almogbel, Lolowh

STATEMENT OF PROBLEMAdditive and subtractive manufacturing have become alternative technologies for fabricating occlusal devices. However, knowledge of the long-term stability of occlusal devices fabricated using these recent technologies is limited.PURPOSEThe purpose of this in vitro study was to evaluate the cameo and intaglio surface stability and variability of additively, subtractively, and conventionally manufactured occlusal devices after 18 months of storage.MATERIAL AND METHODSA standard tessellation language (STL) file of a dentate maxillary typodont was used to design a master occlusal device. The STL file of this design was used to fabricate occlusal devices additively either with a digital light processing (AM-1) or a continuous liquid interface production (AM-2) printer, subtractively with 2 different 5-axis milling units (SM-1 and SM-2), and conventionally (TM-HP) (n=10). STL files of each device's cameo and intaglio surfaces were generated using a laboratory scanner after fabrication and after 18 months of storage in a moist environment. These generated files were imported into an analysis software program (Geomagic Control X) to analyze the dimensional stability of tested devices by using the root mean square method. The average deviation values defined the variability of measured changes over time. Cameo and intaglio surface deviations were analyzed using the Kruskal-Wallis and Dunn tests, while the variability of measured deviations was analyzed with 1-way analysis of variance and the Tukey HSD tests (α=.05).RESULTSSignificant differences were observed among tested devices when the intaglio surface deviations and the cameo surface variability were considered (P<.001). SM-2 had significantly higher intaglio surface deviations than AM-1, SM-1, and AM-2 (P≤.036). Among the test groups, AM-1 had the greatest cameo surface variability (P≤.004).CONCLUSIONSSM-2 resulted in lower intaglio surface stability than the additive and the other subtractive manufacturing technologies, while AM-1 led to the highest cameo surface variability among the test groups.

2024-07-01·Environmental Research

Metabolites and metabolic pathway analysis of sulfadimidine in carp (Cyprinus carpio) based on UHPLC-Q-orbitrap HRMS

Article

作者: Wang, Jiyao ; Ma, Haijian ; Li, Zhaoxin ; Peng, Jixing ; Sun, Xiaojie ; Yang, Qingli ; Ding, Tao ; Xing, Lihong ; Wang, Shuwen ; Lin, Ting

Sulfadimidine (SM₂) is an N-substituted derivative of p-aminobenzenesulfonyl structure. This study aimed to analyze the metabolism of SM₂ in carp (Cyprinus carpio). The carps were fed with SM₂ at a dose of 200 mg/(kg · bw) and then killed. The blood, muscle, liver, kidney, gill, other guts, and carp aquaculture water samples were collected. The UHPLC-Q-Exactive Plus Orbitrap-MS was adopted for determining the metabolites of SM₂ in the aforementioned samples. Twelve metabolites, which were divided into metabolites in vivo and metabolites in vitro, were identified using Compound Discoverer software. The metabolic pathways in vivo of SM₂ in carp included acetylation, hydroxylation, glucoside conjugation, glycine conjugation, carboxylation, glucuronide conjugation, reduction, and methylation. The metabolic pathways in vitro included oxidation and acetylation. This study clarified the metabolites and metabolic pathways of SM₂ in carp and provided a reference for further pharmacodynamic evaluation and use in aquaculture.

100 项与 SM-002 相关的药物交易

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