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更新于：2025-05-07

Aconiazide

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用方式-

作用机制

溶菌素类抗生素

治疗领域

感染

在研适应症-

非在研适应症

分枝杆菌感染

原研机构

Connaught Laboratories Ltd.

在研机构-

非在研机构

National Jewish Center

权益机构-

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C15H13N3O4

InChIKeyMDFXJBQEWLCGHP-UHFFFAOYSA-N

CAS号13410-86-1

关联

100 项与 Aconiazide 相关的临床结果

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100 项与 Aconiazide 相关的转化医学

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100 项与 Aconiazide 相关的专利（医药）

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项与 Aconiazide 相关的文献（医药）

2012-06-01·Applied Surface Science

Adsorption and corrosion-inhibiting effect of 2-(2-{[2-(4-Pyridylcarbonyl)hydrazono]methyl}phenoxy)acetic acid on mild steel surface in seawater

作者: Zhong Li ; Hongxia Xi ; Baoyu Liu ; Qibin Xia

The corrosion inhibition property of a hydrazone derivative, namely 2-(2-{[2-(4-pyridylcabonyl)hydrazono]methyl}phenoxy)acetic acid (PMA) for mild steel surface corrosion in synthetic seawater medium was analyzed by weight loss, electrochem. techniques (potentiodynamic polarization and electrochem. impedance).PMA is a good corrosion inhibitor and the inhibition efficiency increased with the increase of PMA concentration, while the adsorption followed the Langmuir isotherm.XPS, SEM, theor. calculation of electronic d., mol. electrostatic potential and mol. dynamics were carried out to establish mechanism of corrosion inhibition for mild steel with PMA in synthetic seawater medium.The inhibition action of the compound was assumed to occur via adsorption on the steel surface through the active centers in the mol.The corrosion inhibition is due to the formation of a chemisorbed film on the steel surface.

2010-06-15·Acta Crystallographica Section E Structure Reports Online

2-(2-{[2-(4-Pyridylcarbonyl)hydrazinylidene]methyl}phenoxy)acetic acid

Article

作者: Liu, Zheng ; Liu, Bao-Yu ; Xia, Jin-Hong

In the title compound, C(15)H(13)N(3)O(4), the pyridine and benzene rings are nearly perpendicular [dihedral angle = 84.24 (5)°]. In the crystal structure, classical O-H⋯N hydrogen bonding between the OH group of the carboxyl unit and a neighbouring pyridine ring N atom and N-H⋯O hydrogen bonding between the imine NH group and a neighbouring O atom of an acyl unit, together with complementary non-classical C-H⋯O hydrogen bonds between carboxyl O atoms and neighbouring CH groups, link the mol-ecules into a three-dimensional system.

1996-10-01·Risk Analysis2区 · 医学

A Semiparametric Approach to Risk Assessment for Quantitative Outcomes

2区 · 医学

Article

作者: Ronald J. Bosch ; Louise M. Ryan ; David Wypij

Characterizing the dose‐effect relationship and estimating acceptable exposure levels are the primary goals of quantitative risk assessment. A semiparametric approach is proposed for risk assessment with continuously measured or quantitative outcomes which has advantages over existing methods by requiring fewer assumptions. The approach is based on pairwise ranking between the response values in the control group and those in the exposed groups. The work generalizes the rank‐based Wilcoxon‐Mann‐Whitney test, which for the two‐group comparison is effectively a test of whether a response from the control group is different from (larger than) a response in an exposed group. We develop a regression framework that naturally extends this metric to model the dose effect in terms of a risk function. Parameters of the regression model can be estimated with standard software. However, inference requires an additional step to estimate the variance structure of the estimated parameters. An effective dose (ED) and associated lower confidence limit (LED) are easily calculated. The method is supported by a simulation study and is illustrated with a study on the effects of aconiazide. The method offers flexible modeling of the dose effect, and since it is rank‐based, it is more resistant to outliers, nonconstant variance, and other departures from normality than previously described approaches.

100 项与 Aconiazide 相关的药物交易

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