A 12-year-old female patient started with sudden abdominal pain, polyuria, polydipsia, anorexia and a drop in cons-cience level. She was diagnosed with untreated type I diabetes mellitus (diabetic acidosis), with blood sugar of 508 mg/dl upon hospital admission. After one week in the hospital, she started having eyelid ptosis, facial pain, converging strabismus, left side epistaxis and a progressive wor-sening of her general health.Skull and paranasal sinuses CT scan and MRI showed a soft tissue mass in the left nasal cavity, invading the ethmoidal, maxillary and cavernous sinuses and the ipsilateral orbit (Figure 1).An endoscopic-guided tumor biop-sy showed mucormycosis. The patient was started in high doses of endovenous am-phothericin B liposome for 45 days. There was a mild improvement only. Anterior rhinoscopy showed a large brown-greenish mass occupying the entire left nasal cavity.We decided to do a nasosinusal endoscopic exploration. During the proce-dure we noticed a large mass coming from the maxillary sinus and the left nasal cavity. We did an exhaustive surgical debridement and cleaning in the maxillary, ethmoidal and sphenoidal sinuses with hypertonic saline solution, and we also flushed the region with an amphothericin B solution. Histology revealed a zygomycosis by Mu-cor genus fungi.The patient had a favorable outco-me and returned in one week for a review. Upon anterior rhinoscopy, we noticed a fungal mass. A new CT scan suggested tumor recurrence. The patient was then submitted to 29 daily sessions of oxygen therapy in a hyperbaric chamber and the amphothericin B was exchanged for intra-venous itraconazole because of the long term use of the former, and she was also submitted to a rigorous diabetic control.There was a mild improvement and stability on her condition, leading us to choose to do a second look endoscopic exploration. The left nasal cavity was broad and clear, without any evidence of infec-tion. The maxillary sinus ostium was open and there were no signs of mucormycosis.The patient was discharged from the hospital in a stable condition and using oral itraconazole. The endoscopic view confirmed disease clearance. She is currently asymptomatic. Her capillary glucose is strictly controlled. She has nerve palsy of the III and IV cranial nerves on the left, however with good visual acuity and no diplopia.
