We describe a novel wound dressing (HR006) with two components: a lyophilized matrix of the galactomannan from locust bean gum (LBG) and an antioxidant hydration solution (AHsol) containing curcumin and N-acetyl-L-cysteine (NAC). Physico-structural analyses of the LBG matrix revealed homogeneous interconnected pores with high absorbing capacity showing excellent properties for moist wound care (MWC). In an in vitro oxidative stress fibroblast injury model, the AHsol showed relevant protective effects reducing intracellular reactive oxygen species (ROS) production, rescuing cell viability, and regulating expression of inflammation-related genes (COX-2, TNF-α, IL-1α, IL-1β). The new dressing showed good biocompatibility profile as demonstrated by cytotoxicity, hemocompatibility, and skin irritation tests. Moreover, in an in vivo skin wound model in pigs, this dressing enhanced the production of healthy and organized granulation tissue and re-epithelization. In summary, HR006 exhibits significant antioxidant activity, good biocompatibility, and excellent repair capabilities improving tissue remodeling and the healing of wounds.

1988-11-01·Archives of Oto-Rhino-Laryngology

Activation of mucociliary function in chronic rhinitis: a placebo-controlled study

Article

作者: M. Silvasti ; P. Karttunen ; J. Nuutinen

The effect of HR-6 solutions containing adenosine triphosphate (either 0.5 or 5 mg/ml) and placebo on the symptoms of chronic rhinitis was studied in 11 patients in randomized, crossover study. The nasal mucociliary activity present in these patients was measured by a radioisotopic method and was impaired in all patients, varying from 1.4 to 5.5 mm/min with a mean of 3.2 mm/min. The duration of each treatment was 10 days, with wash-out periods of 4 days. The relief of the nasal symptoms was recorded. The active drugs on average improved nasal mucociliary activity by 1.9-2.1 mm/min against placebo (1.4 mm/min). At the end of the trial six patients preferred the active drugs for relief of nasal symptoms, none placebo and five had no preferences. The results indicate the need for long-term studies of HR-6 in patients with impaired mucociliary function.

1985-10-01·International Journal of Pediatric Otorhinolaryngology3区 · 医学

Activation of the impaired nasal mucociliary transport in children: preliminary report

3区 · 医学

Article

作者: Juhani Nuutinen

The effect of HR-6 containing adenosine triphosphate on the impaired mucociliary transport was studied in 13 children. The main symptoms in the children were chronic non-allergic rhinitis, recurrent otitis media, recurrent or chronic maxillary sinusitis and infections of the lower respiratory tract. Initially, the mucociliary transport rate ranged from 0 to 5.6 mm/min, mean 1.8 mm/min. HR-6 increased the mucociliary transport rate by 1.3-3.5, mean 2.0 mm/min. The corresponding figures for the placebo were from 0 to 0.4, mean 0.2 mm/min. These preliminary results indicate further studies with HR-6 in children with impaired mucociliary function are necessary.

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