黄酮醇糖苷(Flavonol Glycosides) - 在研适应症：动脉粥样硬化_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用机制-

治疗领域

在研适应症

非在研适应症

原研机构

在研机构

非在研机构

上海捌加壹医药科技有限公司中国人民解放军海军军医大学

中国人民解放军第二军医大学

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)临床1期

特殊审评特殊审批 (中国)

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结构

分子式C23H24O10

InChIKeyBNBGDJWHOMIMQS-XHPXUCHRSA-N

CAS号1055224-92-4

关联

2

项与黄酮醇糖苷相关的临床试验

CTR20180767 / Completed临床1期

中国健康受试者单次口服黄酮醇糖苷片Ⅰ期安全耐受性和药代动力学试验

通过中国健康受试者单次口服黄酮醇糖苷片，评价黄酮醇糖苷片单次给药在健康受试者中的安全耐受性和药代动力学特征，为后续临床试验方案的制定提供依据。

开始日期2018-06-07

申办/合作机构

上海捌加壹医药科技有限公司

[+1]

CTR20171046 / Completed临床1期

中国健康受试者单次口服黄酮醇糖苷片Ⅰ期安全耐受性和药代动力学预试验

通过健康受试者单次口服黄酮醇糖苷片Ⅰ期安全耐受性和药代动力学预试验，初步评价黄酮醇糖苷片在健康受试者中的安全耐受性和药代动力学特征，为后续临床试验方案的制定提供依据。

开始日期2017-11-28

申办/合作机构

上海捌加壹医药科技有限公司

[+1]

100 项与黄酮醇糖苷相关的临床结果

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100 项与黄酮醇糖苷相关的转化医学

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100 项与黄酮醇糖苷相关的专利（医药）

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15

项与黄酮醇糖苷相关的文献（医药）

2024-08-01·Phytotherapy Research

A randomized, double‐blind, placebo‐controlled study of Cistanche tubulosa and Ginkgo biloba extracts for the improvement of cognitive function in middle‐aged and elderly people

Article

作者: Zheng, Jianheng ; Liu, Hongyue ; Li, Gang ; Liang, Yingzhen ; He, Anli ; Du, Jun ; Wang, Wen' An ; Liu, Xin ; Chen, Liang ; Yang, Binrui

AbstractMild cognitive impairment poses an increasing challenge to middle‐aged and elderly populations. Traditional Chinese medicinal herbs like Cistanche tubulosa and Ginkgo biloba (CG) have been proposed as potential agents to improve cognitive and memory functions. A randomized controlled trial involving 100 Chinese middle‐aged and elderly participants was conducted to investigate the potential synergistic effects of CG on cognitive function in individuals at risk of neurodegenerative diseases. Over 90 days, both CG group and placebo group received two tablets daily, with each pair of CG tablets containing 72 mg echinacoside and 27 mg flavonol glycosides. Cognitive functions were assessed using multiple scales and blood biomarkers were determined at baseline, Day 45, and Day 90. The CG group exhibited significant improvements in the scores of Mini‐Mental State Examination (26.5 at baseline vs. 27.1 at Day 90, p < 0.001), Montreal Cognitive Assessment (23.4 at baseline vs. 25.3 at Day 90, p < 0.001), and World Health Organization Quality of Life (81.6 at baseline vs. 84.2 at Day 90, p < 0.001), all surpassing scores in placebo group. Notably, both the Cognitrax matrix test and the Wechsler Memory Scale‐Revised demonstrated enhanced memory functions, including long‐term and delayed memory, after CG intervention. Moreover, cognitive‐related blood biomarkers, including total tau, pT181, pS199, pT231, pS396, and thyroid‐stimulating hormone, significantly decreased, whereas triiodothyronine and free triiodothyronine significantly increased. No treatment‐related adverse events were reported, and routine blood and urine tests remained stable. These findings indicated that CG supplementation could potentially serve as an effective supplementary solution for enhancing cognitive and memory functions.

2018-10-01·Food Chemistry1区 · 农林科学

Effect of the addition of mannoproteins on the interaction between wine flavonols and salivary proteins

1区 · 农林科学

Article

作者: Dueñas, Montserrat ; García-Estévez, Ignacio ; Ramos-Pineda, Alba M ; Escribano-Bailón, M Teresa

It has been suggested that the addition of flavonols (i.e. white grape skins) improves and stabilizes the color of red wines. However, it has been shown that flavonol glycosides produce a mouth-drying and mouth-coating sensation at very low threshold concentrations. Moreover, the addition of polysaccharides to wines is a practice addressed to improve the smoothness and roundness and correct excessive astringency, so we have studied the effect of the addition of yeast mannoproteins (MP) on the interaction between quercetin 3-glucoside and human salivary peptides. Sensory analysis showed the first evidence of the mannoprotein smoothing effect when the flavonol is added to wine. Additionally, MP/SP/polyphenol interactions were studied using fluorescence spectroscopy, dynamic light scattering and isothermal titration calorimetry. Results obtained indicate not only the existence of interactions between mannoproteins and flavonols but also between mannoproteins and salivary proteins (SP), suggesting a possible formation of protein/polyphenol/polysaccharide ternary complex.

2016-12-01·Biochimica et Biophysica Acta (BBA) - Biomembranes

Effects of flavonol glycosides on liposome stability during freezing and drying

Article

作者: Hincha, Dirk K ; Popova, Antoaneta V

Flavonoids are a large and diverse group of plant secondary metabolites that are mainly present as glycosides. They are often accumulated in response to abiotic stresses such as UV radiation, drought, cold and freezing. The most extensively studied function of flavonoids is their antioxidant activity although their importance as antioxidants in plants has been questioned. We therefore aim to study effects of flavonols on cellular stress tolerance that are independent of their antioxidant function. Here we investigate the effects of the glycosylated flavonols kaempferol-3-O-glucoside, kaempferol-7-O-glucoside, quercetin-3-O-glucoside and quercetin-3-O-rhamnoside on liposome stability after freezing and drying. Insertion of flavonols in lipid bilayers destabilized egg phosphatidylcholine (EPC) liposomes and to a lesser extent vesicles made from equal proportions of EPC and egg phosphatidylethanolamine (EPE) during a freeze-thaw cycle, while liposomes containing the unsaturated non-bilayer lipid 18:2 PE were either unaffected or slightly stabilized. In general, the kaempferol derivatives were more destabilizing for liposomes during freezing than the quercetin derivatives. Fourier-transform infrared spectroscopy revealed that all flavonols were localized in the interfacial region of the lipid bilayers, forming H-bonds with the lipid phosphate and carbonyl groups. The phase transition temperature of dry 16:0/18:1 PC (POPC) and POPC/EPE liposomes was decreased by 75°C and 55°C, respectively. Changes in the vibration bands attributed to the phenolic ring structures of the flavonols in the presence of liposomes provided further evidence of interactions of these molecules in particular with the interfacial region of the bilayers.

100 项与黄酮醇糖苷相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
高胆固醇血症	临床3期	中国	中国人民解放军海军军医大学	2017-09-15
动脉粥样硬化	临床1期	中国	八加一药业股份有限公司	2022-01-30