Mesenchymal Stem Cells Combined With CD25 Monoclonal Antibody and Calcineurin Inhibitors for Treatment of Steroid-resistant Acute Graft-versus-host Disease After Allogeneic Stem Cell Transplantation

The purpose of this study is to compare the efficacy of CD25 monoclonal antibody and calcineurin inhibitors with or without mesenchymal stem cells (MSCs) in treating patients with steroid-resistant acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation.

开始日期2014-09-01

申办/合作机构

南方医院

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100 项与 AST-202 (Aptamer Sciences) 相关的临床结果

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100 项与 AST-202 (Aptamer Sciences) 相关的转化医学

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100 项与 AST-202 (Aptamer Sciences) 相关的专利（医药）

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项与 AST-202 (Aptamer Sciences) 相关的文献（医药）

2005-11-01·Zhonghua nei ke za zhi

[The role of CD25 antibody in unrelated hematopoietic stem cell transplantation].

Article

作者: Jiang, Min ; Chen, Hu ; Li, Yu-hang ; Li, Bo-tao ; Hu, Liang-ding ; Yu, Zhi-yong

OBJECTIVETo explore the role of CD(25) antibody on engraftment and graft-versus-host disease (GVHD) prophylaxis in unrelated hematopoietic stem cell transplantation (UHSCT).METHODSCD(25) 1 mg/kg was given on day 1, day 4 post-transplantation in 27 patients of UHSCT.RESULTSHematopoietic recovery was obtained in 26 patients. One patient died before hematopoietic recovery. Acute GVHD occurred in 17 patients and 6 patients with II or more than degree acute GVHD (23%). Three patients experienced relapse and other 3 patients with serious infection. In these 26 eligible patients, 19 patients got disease free survival.CONCLUSIONSCD(25) antibody plays an important role on engraftment and GVHD prophylaxis in the treatment of UHSCT and does not increase rate of leukemia relapse. It provides a way of GVHD prophylaxis in unrelated and HLA mismatched hematopoietic stem cell transplantation.

1989-01-01·Clinical and Experimental Hypertension. Part A: Theory and Practice

Hyperkinetic Hemodynamic Pattern in some Borderline Hypertension: Differential Responses to Alpha and Beta Agonists

Article

作者: J. Fan ; Q. Yang ; G. Yi

Twenty eight male borderline hypertensive patients(BH), mean age of 19.72 +/- 2.80 years, were studied and matched with 28 normal controls (NC). Alpha-adrenergic responsiveness was estimated with DPD15 (the dosage of neosynephrine required for an increase of diastolic pressure of 15mmHg); beta-adrenergic responsiveness with CD25 (the dosage of isoproterenol required for an increase of heart rate of 25 beats/minute). Using CD25 of 1.0ug (mean of the NC), the BH could be subdivided into two specific types: 13 patients (46%) whose CD25 less than 1.0 ug, 0.50 +/- 0.24 (m +/- SD) had a hyperkinetic pattern; the remaining 15 patients (54%) whose CD25 greater than 1.0ug, 1.76 +/- 0.32 (m +/- SD), had a normokinetic one. Values of DPD15 of the two types were comparable. Cardiac index (CI, L/min/M2) and total peripheral resistance (TPR, dynes/sec/cm-5) of the two types manifested significant differences, both p less than 0.001. When plotting CI and TPR versus CD25, good correlations were obtained. In the BH group, the coefficient r was -0.73 between CI and CD25, + 0.70 between TPR and CD25; correlations were poor when plotting versus DPD15. Similar correlations also happened in the NC. The present study suggests that coexistence of two different hemodynamic patterns may be due to the imbalance resulted from the interaction between alpha-adrenergic responsiveness and beta-adrenergic responsiveness.

Molecular toxicology

Comparison of in vitro cell toxicity with in vivo eye irritation.

Article

作者: Faller, C ; Reinhardt, C A ; Spengler, J ; Bracher, M

The effects of 26 different cosmetic ingredients (e.g., permanent wave and hair dye compounds, emulsifiers, resins, and detergents such as quats) were assessed by four end points indicative for qualitatively and quantitatively different cytotoxicity: (1) neutral red uptake reduction after 24 h of treatment (NR-90 and NR-50); (2) cell detachment from culture dish after 4 h of treatment (CD-25); (3) growth inhibition after 48 h of treatment (GI-50); and (4) membrane permeability measured by fluorescent dye retention (fluorescence shift FS-25) and dye exclusion (viability ratio VR-25). The cytotoxicity potentials of the test agents were ranked for each in vitro test and compared with the in vivo eye irritation in guinea pigs (Draize test) after application of 5 or 2.5% (w/v) solutions of the same test batches. Strong irritants could be easily detected by most of the in vitro tests, but the neutral red uptake assay (especially NR-50) was the only one that was able to distinguish the minimally irritating test agents from strong irritants as well as from nonirritants. (I) All three extremely irritating quaternary ammonia compounds were identified as the strongest cytotoxic agents. (II) Nine out of 12 minimally irritating substances (mainly emulsifiers and resins) were ranked in the intermediate group. (III) Eight out of 11 non-or practically nonirritating chemicals (mainly permanent wave compounds) showed cytotoxic effects at very high concentrations only. The distinction of these three groups was better by means of NR-50 than by NR-90 data. At least two of the other cell tests (CD-25, GI-50, FS-25, and VR-25) had to be considered to allow an adequate interpretation of in vitro cytotoxicity.

100 项与 AST-202 (Aptamer Sciences) 相关的药物交易

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