2-Heteroarylthioalkanoic acid analogues of clofibric acid(University of Chieti-Pescara)(2-Heteroarylthioalkanoic acid analogues of clofibric acid(University of Chieti-Pescara))

概要

基本信息

药物类型

小分子化药

别名-

靶点

PPARα

作用方式

激动剂

作用机制

PPARα激动剂(过氧化物酶体增长因子活化受体α激动剂)

治疗领域

内分泌与代谢疾病

在研适应症-

非在研适应症

高脂血症

原研机构

University of Chieti-Pescara

在研机构-

非在研机构

University of Chieti-Pescara

最高研发阶段无进展药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 2-Heteroarylthioalkanoic acid analogues of clofibric acid(University of Chieti-Pescara) 相关的临床结果

登录后查看更多信息

100 项与 2-Heteroarylthioalkanoic acid analogues of clofibric acid(University of Chieti-Pescara) 相关的转化医学

登录后查看更多信息

100 项与 2-Heteroarylthioalkanoic acid analogues of clofibric acid(University of Chieti-Pescara) 相关的专利（医药）

登录后查看更多信息

1

项与 2-Heteroarylthioalkanoic acid analogues of clofibric acid(University of Chieti-Pescara) 相关的文献（医药）

2009-10-22·Journal of medicinal chemistry1区 · 医学

Synthesis and Biological Evaluation of 2-Heteroarylthioalkanoic Acid Analogues of Clofibric Acid as Peroxisome Proliferator-Activated Receptor α Agonists

1区 · 医学

Article

作者: Amoroso, Rosa ; Giancristofaro, Antonella ; Ammazzalorso, Alessandra ; Moschetta, Antonio ; Giampietro, Letizia ; De Filippis, Barbara ; Maccallini, Cristina ; Petruzzelli, Michele ; Bettoni, Giancarlo ; Lannutti, Fabio ; Morgano, Annalisa ; Fantacuzzi, Marialuigia

A series of 2-heteroarylthioalkanoic acids were synthesized through systematic structural modifications of clofibric acid and evaluated for human peroxisome proliferator-activated receptor alpha (PPARalpha) transactivation activity, with the aim of obtaining new hypolipidemic compounds. Some thiophene and benzothiazole derivatives showing a good activation of the receptor alpha were screened for activity against the PPARgamma isoform. The gene induction of selected compounds was also investigated in the human hepatoma cell line.

100 项与 2-Heteroarylthioalkanoic acid analogues of clofibric acid(University of Chieti-Pescara) 相关的药物交易

登录后查看更多信息