Natural interferon alpha(BioPharm Solutions, Inc.)(Natural interferon alpha(BioPharm Solutions, Inc.))

概要

基本信息

药物类型

干扰素

别名-

靶点

IFNAR

作用机制

IFNAR激动剂(干扰素α/β受体复合体激动剂)

治疗领域-

在研适应症-

非在研适应症-

原研机构

BioPharm Solutions, Inc.

在研机构-

非在研机构

BioPharm Solutions, Inc.

最高研发阶段无进展临床阶段不明

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

1

项与 Natural interferon alpha(BioPharm Solutions, Inc.) 相关的临床试验

JPRN-C000000256 / CompletedIIT

Multi-institute randomized study of natural type interferon alpha for patients with renal cell carcinoma after radical nephrectomy - Trial of RCC adjuvant interferon alpha (TRAIn-Alpha)

开始日期2001-08-01

申办/合作机构-

100 项与 Natural interferon alpha(BioPharm Solutions, Inc.) 相关的临床结果

登录后查看更多信息

100 项与 Natural interferon alpha(BioPharm Solutions, Inc.) 相关的转化医学

登录后查看更多信息

100 项与 Natural interferon alpha(BioPharm Solutions, Inc.) 相关的专利（医药）

登录后查看更多信息

55

项与 Natural interferon alpha(BioPharm Solutions, Inc.) 相关的文献（医药）

2020-08-26·mSphere2区 · 生物学

Comparative Study of Protection against Newcastle Disease in Young Broilers Administered Natural Chicken Alpha Interferon via Oral and Intramuscular Routes

2区 · 生物学

ArticleOA

作者: Aslam, Muhammad Aamir ; Qureshi, Anas Sarwar ; Anjum, Faisal Rasheed ; Rahman, Sajjad Ur

Newcastle disease (ND) is an economically important contagious disease of wild and domestic birds worldwide. The disease causes severe economic losses in terms of production due to high mortality and morbidity in nonvaccinated chickens. Despite extensive vaccination approaches, Newcastle disease (ND) remains a permanent threat to the poultry industry worldwide. In the current study, we used natural chicken IFN-α as an innate immune modulator to counteract ND in chickens. We report that chIFN-α is effective in protecting the chickens against ND and also prevents shedding of the virus, which can then prevent further spread of the disease. We propose that in addition to vaccination, chIFN-α therapy could be an effective option for controlling ND in areas of endemicity.

2013-08-01·Archives of medical research4区 · 医学

Re-treatment with Highly Purified nIFNα in Mexican Nonresponder Patients with Chronic Genotype 1 Hepatitis C

4区 · 医学

Article

作者: Eduardo Marín-López ; Marco Antonio Olivera-Martínez ; Paula Cordero-Pérez ; Liliana Torres-González ; Juan Francisco Sánchez-Avila ; Linda E. Muñoz-Espinosa ; José de Jesús Ernesto Núñez-Camarena ; María Elena Hernández-Gómez ; Rolando Armienta-Sarabia ; Rene Malé-Velázquez

BACKGROUND AND AIMS:

We undertook this study to evaluate the virological response to and presence of adverse events to natural interferon α (nIFNα; Multiferon®) treatment in previously nonresponsive Mexican patients chronically infected with genotype 1 hepatitis C.

METHODS:

Thirty-nine patients received a 4-week induction of 5 days/week of 6 MU nIFNα plus weight-based ribavirin followed by 3 MU of nIFNα three times a week for 44 weeks. The relationship between viral response and incidence of adverse events was analyzed.

RESULTS:

Early viral response (EVR) was age- and sex-dependent, with older male patients being less responsive. Sustained viral response (SVR) was evaluated according to: a) intention to treat analysis, b) 48-week treatment and 24-week follow-up (16 patients), and c) patients with EVR (11 patients). None of the factors was significantly different in groups a) and b); however, in group c) there was a better response with a marked viral load decline in younger patients and in patients aged 50 years and older. Five of 39 (13%) patients who completed treatment presented with an SVR. The most common adverse effect was asthenia in 27% of patients.

CONCLUSIONS:

nIFNα could be a useful strategy for re-treatment in chronic hepatitis C, genotype 1, in previously nonresponsive patients. Confirmation of these data in a larger population is required.

2013-02-01·International journal of clinical oncology3区 · 医学

Randomized controlled study of natural interferon α as adjuvant treatment for stage II or III renal cell carcinoma

3区 · 医学

Article

作者: Noriaki Tokuda ; Tomoyasu Tsushima ; Shiro Hinotsu ; Seiichiro Ozono ; Hideyuki Akaza ; Koji Kawai ; Seiji Naito ; Koichiro Nomata

BACKGROUND:

The prophylactic effect of postoperative interferon on recurrence and distant metastasis in stage II or III renal cell carcinoma is unclear. In most studies, interferon has been administered for 6 months or less. Therefore, we performed a clinical study of the efficacy of 1-year postoperative administration of natural interferon α, which is generally used in Japan.

METHODS:

The subjects were patients diagnosed with stage II or III renal cell carcinoma who underwent radical nephrectomy. The subjects were randomly allocated to receive an intramuscular injection of natural interferon α (3 million to 6 million units) 3 times a week for 1 year or to receive follow-up observation until recurrence or metastasis occurred. Chest and abdominal CT were performed once yearly for all patients. The primary endpoint was progression-free survival.

RESULTS:

From September 2001 to August 2006, a total of 107 patients were registered, but 7 subsequently withdrew from the study. Therefore, 100 patients were included in the analysis. The primary endpoint of progression-free survival did not differ significantly between the groups that received natural interferon α or follow-up observation (p = 0.456, log-rank test). However, peak hazards of progression in the interferon group were delayed for about 6-10 months compared with the observation group.

CONCLUSION:

Progression-free survival showed no improvement after administration of natural interferon α to patients with stage II or III renal cell carcinoma for 1 year after radical nephrectomy. The peak hazards of progression might be delayed by about 6 months by interferon administration.

100 项与 Natural interferon alpha(BioPharm Solutions, Inc.) 相关的药物交易

登录后查看更多信息

研发状态

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASCO2004	N/A	晚期肾细胞癌	71	IFN alone	築顧淵簾構願餘鑰鹽齋(鑰鏇範鏇積鬱齋鹹廠夢) = 築鬱醖構顧選衊糧積壓願鹹衊淵簾顧壓築膚顧 (鹹築齋繭鏇窪範艱糧襯 ) 更多	-	2004-07-15
				IFN + cimetidine	築顧淵簾構願餘鑰鹽齋(鑰鏇範鏇積鬱齋鹹廠夢) = 願夢齋鬱繭網艱憲淵憲願鹹衊淵簾顧壓築膚顧 (鹹築齋繭鏇窪範艱糧襯 ) 更多