三硬脂酸甘油酯(Glyceryl Trierucate)

概要

基本信息

药物类型

小分子化药

别名

Trierucin、glyceryl trierucate

靶点-

作用机制-

治疗领域

神经系统疾病遗传病与畸形内分泌与代谢疾病+ [1]

在研适应症-

非在研适应症

肾上腺脑白质营养不良

原研机构

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

在研机构-

非在研机构

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

最高研发阶段无进展临床阶段不明

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

2

项与三硬脂酸甘油酯相关的临床试验

NCT02233257 / No longer availableN/AIIT

Expanded Access for Lorenzo's Oil (GTO/GTE) in Adrenoleukodystrophy

X-linked adrenoleukodystrophy (ALD) is a genetic disorder affecting the brain and adrenal glands. Approximately one third of boys who are at risk will develop cerebral disease. Using a specific diet and the compound Lorenzo's oil, it can be shown that very long chain fatty acids may be lowered in the blood, but it is not known to what degree that may prevent the onset of childhood disease.
This proposal makes available Lorenzo's oil to individuals with ALD, a life threatening disorder for which there are presently no other therapies.

开始日期-

申办/合作机构

University of Minnesota

NCT00004450 / CompletedN/AIIT

Randomized Study of Beta Interferon and Thalidomide in Patients With Adrenoleukodystrophy

OBJECTIVES: I. Evaluate the efficacy of interferon beta and thalidomide in male patients with adrenoleukodystrophy who show evidence of brain inflammatory response and are receiving concurrent glyceryl trierucate and glyceryl trioleate (Lorenzo's oil).
II. Evaluate the progress of the disease and possible side effects of the medication in these patients.

开始日期1998-08-01

申办/合作机构

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

100 项与三硬脂酸甘油酯相关的临床结果

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100 项与三硬脂酸甘油酯相关的转化医学

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100 项与三硬脂酸甘油酯相关的专利（医药）

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123

项与三硬脂酸甘油酯相关的文献（医药）

2024-09-17·Langmuir

Increased Ordering of Potassium Stearate/Stearic Acid/Glyceryl Stearate Confined between Swollen Cross-Linked Poly(acrylic acid)

Article

作者: Shi, Shanling ; Liu, Chung-Hao ; Song, Qing ; Shih, Kuo-Chih ; Burford, Mark ; Chang, Shing-Yun ; Nieh, Mu-Ping ; Ma, Anson W. K. ; Chen, Liang Bin ; Moaddel, Teanoosh

In this paper, we investigate the phase behavior of a surfactant mixture comprising glyceryl stearate, potassium stearate, and stearic acid, in the presence of Carbopol, a commonly used thickener in personal care products. At low Carbopol concentrations (<0.03%), the surfactant mixture interacted with Carbopol electrostatically, increasing the degree of Carbopol swelling and, consequently, the overall viscosity. However, such an effect diminished as the Carbopol concentration was further increased. At a Carbopol concentration of 0.2%, two types of liquid crystalline surfactant structures, namely, multilamellar vesicles and lamellae, were observed between the swollen Carbopol domains. Although similar types of surfactant structures were present in a much more concentrated surfactant solution having a similar viscosity but without Carbopol, the lamellae in the presence of Carbopol were more ordered and with a larger d spacing. The increased ordering was probably induced by the interactions between the surfactants and Carbopol as the surfactants were confined between the swollen Carbopol domains.

2024-04-01·International Journal of Pharmaceutics

Novel solid self-emulsifying drug delivery system to enhance oral bioavailability of cabazitaxel

Article

作者: Gou, Jingxin ; Zhao, Jingyi ; Yin, Tian ; Sun, Xianxiong ; Tang, Xing ; Zhao, Jiansong ; Lv, Gaoshuai ; He, Haibing ; Wang, Yuntao ; Xiong, Jian ; Wang, Zhipeng ; Zhang, Yu

In this study, a novel cabazitaxel solid self-emulsifying drug delivery system (CTX S-SEDDS) was developed by solvent evaporation and liquid-solid compression technology, which overcame the limitations of the traditional SEDDS and improved the oral bioavailability. From the results of solubility, pseudo-ternary phase diagram, and single-factor analysis, Tween 80 (surfactant), Tricaprylin (oil), and Glyceryl monooleate (oil) with the ratio of 30:55:15 showed optimized particle size (140.87 nm), short emulsification and high cabazitaxel (CTX) loading capacity (50 mg·g^-1). Based on the liquid-solid compression mathematical model, Syloid XDP3050 was determined as carrier material and Syloid 244FP as coating material. The prepared CTX S-SEDDS showed excellent flowability, tabletability, and reconstitution property. In vivo pharmacokinetics in rats demonstrated the absolute bioavailability of CTX S-SEDDS (17.27 %) was significantly enhanced compared with CTX solution (1.69 %), which was close to that of CTX-SEDSS (20.48 %). Lymphatic absorption was verified by in vitro imaging to be an important absorption route for self-emulsifying preparations. These results suggested that CTX S-SEDDS could enhance oral bioavailability of poorly water-soluble drug cabazitaxel while avoiding SEDDS limitations and harnessing the dual advantages of solid and liquid preparations.

2024-03-01·International Journal of Biological Macromolecules

Preparation and characterization of glyceryl stearate/cassava starch composite for wax therapy

Article

作者: Chankachang, Phanlob ; Raksanti, Anucha ; Koonawoot, Rungsarit ; Thiansem, Sakdiphon ; Punyanitya, Sittiporn

Glyceryl stearate and cassava starch (CS) composites were prepared by an esterification process. Formulations containing starch at various concentrations were prepared, being 1, 1.5, 3, 5, 10, 15, 20, and 30 % by weight, respectively. The characteristics of pH, moisture content, FTIR, melting point, latent heat, thermal energy storage, and specific heat capacity of composites were elucidated. The optimal formulation contained 1 % w/w CS, this indicated that the composite was able to maintain its temperature for 9.4 ± 0.5 min, with a melting temperature of 51.9 ± 0.3 °C, solidification temperature of 36.1 ± 1.6 °C, latent heat of fusion of 120 ± 10 J/g, and latent heat of solidification of 126 ± 3 J/g, and specific heat capacity of 2.6 ± 0.2 J/g.K. New bonds were formed in the composite structure of glyceryl stearate and CS at these levels. The composite had a pH that was safe for contact with human skin and a moisture content that could be kept stable for a prolonged time. The innovation and the advantages of a composite materials: 1. The main components are derived from natural materials. 2. Costs effective 3. Sustainability 4. Safety, and 5. Efficacy. Therefore, composites have a high potential as are replacement for paraffin wax bath therapy.

100 项与三硬脂酸甘油酯相关的药物交易

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