Diumycin A(Diumycin A) - 药物靶点：Peptidoglycan_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点

Peptidoglycan

作用方式

抑制剂

作用机制

肽聚糖抑制剂、细胞壁抑制剂

治疗领域

感染

在研适应症-

非在研适应症

金黄色葡萄球菌感染

原研机构

Mart Microbiology BV

在研机构-

非在研机构

Mart Microbiology BV

权益机构-

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 Diumycin A 相关的临床结果

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100 项与 Diumycin A 相关的转化医学

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100 项与 Diumycin A 相关的专利（医药）

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2

项与 Diumycin A 相关的文献（医药）

1973-01-01·The Journal of antibiotics4区 · 医学

DIUMYCIN A'' AND DIUMYCIN B'', NEW MEMBERS OF THE DIUMYCIN FAMILY OF ANTIBIOTICS

4区 · 医学

Article

作者: Weisenborn, Frank L. ; Slusarchyk, William A. ; Bouchard-Ewing, Jacqueline L.

The preliminary characterization of P-containing diumycin A' and diumycin B', isolated from the diumycin complex of antibiotics produced by Streptomyces umbrinus ATCC 15972 indicated the presence of 2 active components in addition to diumycin A and diumycin B.A 90% pure antibiotic preparation containing the 4 components was obtained.Countercurrent distribution combined with chromatog. over silica gel gave pure samples of diumycins A, A', B, and B'.Diumycin A, like diumycin A', showed a strong absorption at 257 nm, while diuymcin B' and diumycin B showed no absorption at wavelengths >220 nm.Diumycins A and B, but not diumycins A' and B', contain glucose.Each compound contains 2 equivalents of glucosamine and 3 of NH3.

1972-12-01·Antimicrobial agents and chemotherapy2区 · 医学

Inhibition of Peptidoglycan Synthesis by the Antibiotic Diumycin A

2区 · 医学

Article

作者: Van De Berg, G. J. ; Lugtenberg, E. J. J. ; Hellings, J. A.

Diumycin A, a new antibiotic, was found to inhibit cell wall synthesis by Staphylococcus aureus , a phenomenon accompanied by accumulation of uridine-5′-diphosphate- N -acetyl-muramyl-pentapeptide. The antibiotic inhibited in vitro peptidoglycan synthesis by particulate preparations of Bacillus stearothermophilus and Escherichia coli by preventing the utilization of N -acetyl-glucosamine- N -acetyl-muramyl-pentapeptide. In contrast to vancomycin, the antibiotics diumycin, prasinomycin, moenomycin, 11.837 RP, and enduracidin do not inhibit particulate d -alanine carboxypeptidase.

100 项与 Diumycin A 相关的药物交易

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