The aim of the study is to compare and assess the efficacy of combined letrozole with myoinositol, chromium, or L-arginine in infertile women with PCOS. This study will help in the investigation of alternative therapeutic modalities for fertility improvement in polycystic ovarian syndrome

开始日期2024-06-30

申办/合作机构

Beni-Suef University

IRCT20140804018677N28 / Recruiting临床3期

Assessing the effects of sachet containing famous vulgaris extract, Morus Alba leaf extract, Coffee robusta extract, Magnesium citrate and chromium picolinate and weight reduction diet compared to diet alone on weight loss in obese or overweight adults

开始日期2023-09-06

申办/合作机构-

ACTRN12624000777594 / Completed临床2期IIT

Effects of chromium picolinate as an adjuvant on HbA1c levels in diabetic patients, and on eGFR and serum creatinine levels in diabetes induced renal impaired patients.

开始日期2022-10-05

申办/合作机构-

100 项与吡啶甲酸铬相关的临床结果

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100 项与吡啶甲酸铬相关的转化医学

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100 项与吡啶甲酸铬相关的专利（医药）

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项与吡啶甲酸铬相关的文献（医药）

2024-08-01·Animal Bioscience

Administration of chromium picolinate and meloxicam alleviates regrouping stress in dairy heifers

Article

作者: Kim, Hyun Jin ; Kim, Do Hyun ; Jeong, In Hyuk ; Cho, In Gu ; Beak, Seok-Hyeon ; Jung, Da Jin Sol ; Lee, Jin Oh ; Yoo, Seon Pil ; Lee, Jaesung ; Baik, Myunggi ; Malekkhahi, Mohammad ; Fassah, Dilla Mareistia ; Hong, Soo Jong

Objective: This research investigated the effect of administering chromium (Cr) and meloxicam (MEL) on growth performance, cortisol and blood metabolite, and behaviors in young, regrouped heifers.Methods: Fifty Holstein dairy heifers (body weight [BW] 198±32.7 kg and 6.5±0.82 months of age) were randomly assigned to non-regrouped group or four regrouped groups. Non-regrouped animals were held in the same pen throughout the entire experimental period (NL: non-regrouping and administration of lactose monohydrate [LM; placebo]). For regrouping groups, two or three heifers maintained in four different pens for 2 weeks were regrouped into a new pen and assigned to one of four groups: regrouping and LM administration (RL); regrouping and Cr administration (RC); regrouping and MEL administration (RM), and regrouping and Cr and MEL administration (RCM). LM (1 mg/kg BW), Cr (0.5 mg Cr picolinate/kg dry matter intake), and MEL (1 mg/kg BW) were orally administered immediately before regrouping. Blood was collected before regrouping (0 h) and at 3, 9, and 24 h and 7 and 14 d thereafter. Behaviors were recorded for 7 consecutive days after regrouping.Results: Average daily gain was lower (p<0.05) in RL than NL heifers, but was higher (p<0.05) in RM, RC, and RCM than RL heifers. RL heifers had higher (p<0.05) cortisol than NL heifers on d 1 after regrouping. The cortisol concentrations in RC, RM, and RCM groups were lower (p<0.05) than in RL treatment 1 d after regrouping. Displacement behavior was greater (p<0.05) in RL group than all other groups at 2, 3, and 6 d after regrouping.Conclusion: Regrouping caused temporal stress, reduced growth performance, and increased displacement behavior in heifers. Administering Cr and MEL recovered the retarded growth rate and reduced displacement behavior, thereby alleviating regrouping stress.

2024-07-03·Cureus

Charting Wellness in India: Piloting the iTHRIVE’s Functional Nutrition Approach to Improve Glycaemic and Inflammatory Parameters in Prediabetes and Type 2 Diabetes Mellitus

Article

作者: Jain, Ria ; Joseph, Anitta ; Pradhan, Mugdha ; Hedaoo, Radhika

Introduction Type 2 diabetes mellitus (T2DM) is characterized by elevation of blood glucose levels due to underlying insulin resistance and inflammation. Multiple modifiable risk factors such as unhealthy dietary habits, physical inactivity, obesity, smoking and psychological stress contribute to T2DM. We investigated the efficacy of a comprehensive functional nutrition approach aimed at mitigating T2DM using the iTHRIVE approach which encompassed anti-inflammatory and elimination diets, micronutrient supplements, physical activity, stress management and environmental modifications through a pre-post study design. The research assessed changes in blood glucose and inflammatory markers following the implementation of the functional nutrition program. Methods A prospective pre-post intervention pilot study was conducted at ThriveTribe Wellness Solutions Pvt Ltd. (iTHRIVE), where 50 study participants from urban areas of Pune city, India (n=25 each group) were recruited voluntarily in the age group of 20-60 years. The participants were subjected to 90 days of the iTHRIVE functional nutrition approach which consisted of eliminating certain inflammatory foods and adding a combination of nutritious organic foods, adding dietary supplements like magnesium, vitamin D, alpha lipoic acid, chromium picolinate, berberine and biogymnema, physical activities like resistance training, stress reduction techniques like meditation and deep breathing exercises along with environmental changes. The blood parameters like fasting blood glucose, postprandial blood glucose, glycated haemoglobin (HbA1C), fasting serum insulin, post-prandial serum insulin, high sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), vitamin D, body weight and waist circumference were measured before and after the intervention. The changes were statistically analyzed using a paired t-test. Results The mean age of the participants was found to be 43.76±10.58 years. Around 68% of the participants were prediabetic (HbA1c: 5.7-6.4%) and 32% had T2DM (HbA1c ≥6.5%). A significant reduction was observed in the average HbA1c (13.75% reduction, p<0.0001), average post-prandial blood glucose levels (14.51% reduction, p<0.048), average post-prandial serum insulin (34.31% reduction, p<0.017) and average ESR levels (34.51% reduction, p<0.006). The hs-CRP levels were reduced by 6.6%, but not statistically significant. The average body weight of the participants dropped from 78.59±15.18 kg to 75.20±14.20 kg with a mean loss of 2.91 kg (p<0.05) whereas the waist circumference decreased from 37.54±5.09 to 35.97±4.74 inches with an average loss of 1.19 inches (p<0.0004). Conclusions Following the intervention, several health indicators indicated significant improvements. Particularly, there was a significant drop in HbA1c levels, suggesting better long-term blood glucose control. Blood glucose and serum insulin levels after a meal dropped significantly, indicating enhanced insulin sensitivity. There was a decrease in systemic inflammation as evidenced by the decrease in ESR levels. These results imply that the iTHRIVE functional nutrition approach used in this investigation might be beneficial for enhancing glycemic control and insulin sensitivity, along with reducing inflammatory markers in people with prediabetes and T2DM. Larger sample sizes and longer periods of monitoring would be useful in subsequent research to validate and build on these encouraging findings.

2024-06-01·APL Bioengineering

Silk fibroin promotes H3K9me3 expression and chromatin reorganization to regulate endothelial cell proliferation

Article

作者: Xie, Yafan ; Xu, Fangning ; Qiu, Juhui ; Gao, Kaixiang ; Wang, Guixue ; Peng, Qin ; Fu, Li

Silk fibroin (SF), which is extensively utilized in tissue engineering and vascular grafts for enhancing vascular regeneration, has not been thoroughly investigated for its epigenetic effects on endothelial cells (EC). This study employed RNA sequencing analysis to evaluate the activation of histone modification regulatory genes in EC treated with SF. Subsequent investigations revealed elevated H3K9me3 levels in SF-treated EC, as evidenced by immunofluorescence and western blot analysis. The study utilized H2B-eGFP endothelial cells to demonstrate that SF treatment results in the accumulation of H2B-marked chromatin in the nuclear inner cavities of EC. Inhibition of H3K9me3 levels by a histone deacetylase inhibitor TSA decreased cell proliferation. Furthermore, the activation of the MAPK signaling pathway using chromium picolinate decreased the proliferative activity and H3K9me3 level in SF-treated EC. SF also appeared to enhance cell growth and proliferation by modulating the H3K9me3 level and reorganizing chromatin, particularly after oxidative stress induced by H2O2 treatment. In summary, these findings indicate that SF promotes EC proliferation by increasing the H3K9me3 level even under stress conditions.

项与吡啶甲酸铬相关的新闻（医药）

2024-01-22

·PRNewswire

GNC Introduces Game Changing Weight Loss Solution Total Lean® GlucaTrim™

New Science-Backed Supplement Leverages Clinically Proven Botanicals to Support Weight Loss & Blood Glucose, While Maintaining Lean Muscle PITTSBURGH, Jan. 22, 2024 /PRNewswire/ -- GNC, the global powerhouse in health and wellness, today announced the debut of GNC Total Lean® GlucaTrim™ , the new multi-action weight loss supplement designed to help users drop pounds and lose inches by utilizing an innovative formula that maintains lean muscle mass, while supporting healthy blood sugar and insulin levels. GlucaTrim offers solutions to the issues facing health-conscious consumers interested in weight loss without a prescription. Continue Reading GNC's Total Lean GlucaTrim is available today at any GNC near you and GNC.com "The team at GNC is hyper-focused on our customers' health, recognizing the increasing demand for effective weight loss," says Rachel Jones, MS RDN and senior vice president, chief product innovation and science officer at GNC. "GNC Total Lean GlucaTrim gives consumers an affordable, non-prescription, botanical-focused supplement that's backed by a team of scientists and dietitians who are passionate about helping people reach their weight loss goals." A key feature of GlucaTrim is its effectiveness in protecting against the loss of lean mass and muscle. Many trending weight loss solutions significantly reduce lean mass and muscle, leaving negative impacts on metabolism and long-term weight loss. The breakthrough formulation used in GlucaTrim is proven to support metabolism in the user's weight loss journey by protecting against the loss of critical muscle mass. The multifaceted supplement features Slimvance®, a botanical blend clinically proven to help lose nearly 12 pounds and fuel weight loss results starting in just two weeks^*. This key component works with metabolism to increase calorie burning for those looking to break through plateaus and achieve real weight loss. This groundbreaking supplement also leverages other proven botanicals including Reducose®, a clinically proven leaf extract that supports the optimal balance of blood glucose and insulin after a meal, Chromax® to support healthy glucose and insulin levels, and Berberine, shown to support blood sugar and increase weight loss^*. The introduction of GlucaTrim reinforces GNC's position as a leader in the weight loss market which has soared this past year with consumers increasingly searching for and purchasing effective weight loss solutions. For the past 15 years GNC Total Lean has been helping people reach their wellness goals with a wide range of products, which can all be used with the new GlucaTrim product. The comprehensive range of Total Lean offerings includes the Total Lean meal replacement shakes in both powder and ready-to-drink formats, Lean Bars, and weight management supplements Total Lean 60 Burn and Total Lean CLA. GlucaTrim is a caffeine-free supplement that should be taken daily before the two largest meals and works in tandem with a healthy diet and exercise program. GlucaTrim is available now exclusively at GNC retail stores nationwide and online at . Members of myGNC Rewards and PRO Access who subscribe to receive GlucaTrim regularly through the GNC Routines program can earn up to $50 in bonus cash back rewards every year, as well as receive a 10% discount and free shipping on every order. To learn more about GNC, please visit and follow for updates at @gnclivewell. ^ A 16-week randomized clinical study of 140 healthy, overweight people compared the use of Slimvance® with an 1,800-calorie diet & walking plan to a placebo with the s ame diet & walking plan. Those on Slimvance® lost a statistically significant amount of weight, 11.81 pounds, while the placebo group lost 1.91 pounds vs. baseline. The Slimvance® group saw weight loss results in as soon as 2 weeks. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. About GNC GNC is a leading global health and wellness brand that provides customers with a wide variety of science-based products and solution services to Live Well. The brand touches consumers worldwide by providing its products and services through company-owned retail locations, domestic and international franchise locations, digital commerce and strong wholesale and retail partnerships across the globe. GNC's diversified, multi-channel business model has worldwide reach and a well-recognized, trusted brand. By combining exceptional innovation, product development capabilities and an extensive global distribution network, GNC manages a best-in-class product portfolio. . Media Contact: Allison General Inquiries [email protected] SOURCE GNC

临床结果

2023-11-17

·PRNewswire

Power Life by Tony Horton Introduces New High Impact Protein Flavor - Strawberry Vanilla

This Delicious Strawberry Vanilla Flavored Protein Powder is Specifically Crafted to Enhance Muscle Strength and Aid in Post-Workout Recovery LOS ANGELES, Nov. 17, 2023 /PRNewswire/ -- Power Life™ by Tony Horton announces the launch of the latest flavor of their best-selling protein powders - Strawberry Vanilla High Impact Whey Protein and Strawberry Vanilla High Impact Plant Protein. Created by fitness legend Tony Horton, these protein powder supplements are packed with a powerful blend of proteins, vitamin D3, HMB, and digestive enzymes. Together, these ingredients help nourish muscles, and support muscle-building, muscle strength, and overall health.†* Continue Reading Power Life™ by Tony Horton announces the launch of the latest flavor of their best-selling protein powders - Strawberry Vanilla High Impact Whey Protein and Strawberry Vanilla High Impact Plant Protein. Created by fitness legend Tony Horton, these protein powder supplements are packed with a powerful blend of proteins, vitamin D3, HMB, and digestive enzymes. Here are the ingredients and unique benefits that each of these Power Life proteins has to offer: Power Life High Impact Whey Protein ($69.95): this protein contains ethically sourced whey from grass-fed cows in the United Kingdom. Combined with HMB + Vitamin D3, Aquamin®, and ChroMax®, this unique blend helps nourish your muscles, support your strength, and support the preservation of lean muscle.†* Power Life High Impact Plant Protein ($69.95): packed with a vegan protein blend derived from pea, rice, fava, mung bean, and pumpkin seed, this plant protein powder is a nutritional powerhouse. Plus, it's also fortified with HMB, Vitamin D3, Aquamin®, and ChroMax®. Harnessing the benefits of Aquamin's® nutrient-rich algae-based superfood, it supports strong bones and muscles. Whether it's your active days or well-deserved rest days, this protein blend and essential vitamins have your muscle strength and overall health covered.†* Along with the new strawberry vanilla flavor, Power Life High Impact Whey Protein and Power Life High Impact Plant Protein are also available in chocolate and vanilla, which can all be purchased on the Power Life website. *All individuals are unique. Your results can and will vary. †These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. About Power Life Founded in 2020, Power Life products embody the highest standard of quality in nutrition. Made with scientifically backed ingredients for optimum effectiveness, Power Life was created by fitness legend Tony Horton to provide a nutritional roadmap for consumers, helping them find strength and the best support from the inside out at any age. Other Power Life products include dietary supplements such as Foundation Phytonutrients, Peak Advantage, and High Impact Plant Protein. For more information, please visit mypowerlife.com or Instagram @my_powerlife and TikTok @my_powerlife. About Tony Horton Tony Horton is the creator of the most successful fitness program in America, P90X®. He is a world-class motivational speaker and author of bestsellers Bring It, Crush It, and The Big Picture. Along with his new fitness concept Power Nation Fitness, Tony's supplement line Power Life supports people's health through proper nutrition. He's appeared on countless television programs as a fitness and lifestyle expert to promote healthy living through exercise and proper nutrition. He hosts the YouTube series "Power Up With Tony Horton" where he interviews notable guests while taking them through a one-of-a-kind physical challenge. Follow Tony Horton on Instagram @tonyshorton. Media Contact Sami Delavari [email protected] John Filizzola [email protected] SOURCE Power Life

100 项与吡啶甲酸铬相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
代谢综合征	临床2期	埃及	Benha University	2020-08-01
体重增加	临床2期	-	NXXI, Inc.	2008-09-30
肥胖	临床2期	-	University of North Carolina - Chapel Hill Endowment Fund	2008-07-31
肥胖	临床2期	-	University of North Carolina - Chapel Hill Endowment Fund	2008-07-31
2型糖尿病	临床2期	美国	National Center for Complementary and Integrative Health	2005-11-30
2型糖尿病	临床2期	美国	National Center for Complementary and Integrative Health	2005-11-30
高血压	临床2期	美国	National Center for Complementary and Integrative Health	2005-11-30
高血压	临床2期	美国	National Center for Complementary and Integrative Health	2005-11-30
胰岛素抵抗	临床2期	美国	National Center for Complementary and Integrative Health	2005-11-30
胰岛素抵抗	临床2期	美国	National Center for Complementary and Integrative Health	2005-11-30

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


Pubmed \| J Nutr Biochem	N/A	超重	35	Chromium picolinate	(壓鹽夢窪餘憲糧選簾艱) = 憲鹹壓夢蓋鑰網積簾廠壓襯糧構鏇鹽淵簾壓鹹 (製觸衊鏇憲蓋糧築製選 ) 更多	-	2008-01-01
				Chromium picolinate	(壓鹽夢窪餘憲糧選簾艱) = 憲選襯衊淵廠願窪窪膚壓襯糧構鏇鹽淵簾壓鹹 (製觸衊鏇憲蓋糧築製選 ) 更多