3-HPT

In this study, the fruits of both mature and air-dried figs were exposed to selective sequential extracting processes using soxhlet.Different polarity and non-polarity solvents were used to increase the yield of the isolated extractsThe aim of current work is to deal with the synthesis of a novel compound 2-benzhydrylsulfinyl-n-hydroxyacetamide-Na from fig fruit and study its effect as anticancer and anti-proliferative agent against SKOV-3, and AMJ-13 cells.Treated cancer cells with 2-benzhydrylsulfinyl-n-hydroxyacetamide-Na significantly increased ROS synthesis, with subsequent reduction of the MMP through mechanisms that included Bax upregulation P⁵³, Caspase-8, and Caspase-9 and Bcl-2 downregulation.The outcomes of the current study show that 2-benzhydrylsulfinyl-n-hydroxyacetamide-Na extracted from fig fruit suppressed cancers cells' proliferation, resulting in apoptosis as a novel pathway that involves mitochondrial mechanism via activated P53 and caspase-8 signaling.In addition, the extract exerted no toxic effects, neither on serum levels of liver functional enzymes nor on the normal histol. architecture of the lungs and spleen.We demonstrated how the 2-benzhydrylsulfinyl-n-hydroxyacetamide-Na affects cancer cells along with a study the possible mechanisms involved in this effect which is mitochondrial damage and P⁵³ pathway.We conclude that 2-benzhydrylsulfinyl-n-hydroxyacetamide-Na holds a promising potential as an anticancer therapeutic agent.