ZIKV quaternary epitopes-specific antibody(Humabs)(ZIKV quaternary epitopes-specific antibody(Humabs))

概要

基本信息

药物类型

单克隆抗体

别名-

靶点

NS1 x syncytin

作用方式

抑制剂

作用机制

NS1抑制剂(非结构蛋白1抑制剂)、syncytin抑制剂(endogenous retrovirus group W member 1, envelope inhibitors)

治疗领域

感染其他疾病

在研适应症-

非在研适应症

寨卡病毒感染

原研机构

Humabs LLC

在研机构-

非在研机构

Humabs LLC

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 ZIKV quaternary epitopes-specific antibody(Humabs) 相关的临床结果

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100 项与 ZIKV quaternary epitopes-specific antibody(Humabs) 相关的转化医学

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100 项与 ZIKV quaternary epitopes-specific antibody(Humabs) 相关的专利（医药）

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1

项与 ZIKV quaternary epitopes-specific antibody(Humabs) 相关的文献（医药）

2016-08-19·Science1区 · 综合性期刊

Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection

1区 · 综合性期刊

Article

作者: Corti, Davide ; Varani, Luca ; Stettler, Karin ; Beltramello, Martina ; Mele, Federico ; Simonelli, Luca ; Pedotti, Mattia ; Blum, Johannes ; Atkinson, Barry ; Percivalle, Elena ; Minola, Andrea ; Cassotta, Antonino ; Cameroni, Elisabetta ; Sallusto, Federica ; Harris, Eva ; Graham, Victoria ; Espinosa, Diego A. ; Baldanti, Fausto ; Dowall, Stuart ; Jaconi, Stefano ; Lanzavecchia, Antonio ; Hewson, Roger ; Foglierini, Mathilde ; Simmons, Cameron P. ; Bianchi, Siro ; Vanzetta, Fabrizia

Zika virus (ZIKV), a mosquito-borne flavivirus with homology to Dengue virus (DENV), has become a public health emergency. By characterizing memory lymphocytes from ZIKV-infected patients, we dissected ZIKV-specific and DENV-cross-reactive immune responses. Antibodies to nonstructural protein 1 (NS1) were largely ZIKV-specific and were used to develop a serological diagnostic tool. In contrast, antibodies against E protein domain I/II (EDI/II) were cross-reactive and, although poorly neutralizing, potently enhanced ZIKV and DENV infection in vitro and lethally enhanced DENV disease in mice. Memory T cells against NS1 or E proteins were poorly cross-reactive, even in donors preexposed to DENV. The most potent neutralizing antibodies were ZIKV-specific and targeted EDIII or quaternary epitopes on infectious virus. An EDIII-specific antibody protected mice from lethal ZIKV infection, illustrating the potential for antibody-based therapy.

100 项与 ZIKV quaternary epitopes-specific antibody(Humabs) 相关的药物交易

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