A Study of the Use of Combination of Anti-cholinergic and Minor Tranquilliser in the Treatment of Non-cardiac Chest Pain - a Double Blind Placebo Controlled Study

Non-cardiac chest pain is a common clinical problem encountered in our practice but at present, the results of treatments are unsatisfactory. The pathogenesis remains unknown but altered motility of the esophagus and psychological factors including anxiety have been implicated as important factors. Reports of the single use of anticholinergic drugs and anxiolytics have yielded conflicting results, has been demonstrated to yield marginal or of no value. However the use of the combination therapy, especially with a double blind fashion have not been reported. On that basis, we propose to use a combination of anti-cholinergic and tranquilliser for the symptomatic treatment of non-cardiac chest pain. The aim of this study is to evaluate the efficacy of combination therapy of anti-cholinergic and anxiolytic drugs in the treatment of non-cardiac chest pain.

开始日期2002-06-01

申办/合作机构

Hospital Authority (Hong Kong)

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100 项与盐酸氯氮䓬/克利溴胺相关的临床结果

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100 项与盐酸氯氮䓬/克利溴胺相关的转化医学

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100 项与盐酸氯氮䓬/克利溴胺相关的专利（医药）

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项与盐酸氯氮䓬/克利溴胺相关的文献（医药）

2015-03-01·Journal of separation science3区 · 化学

Validated green high‐performance liquid chromatographic methods for the determination of coformulated pharmaceuticals: A comparison with reported conventional methods

3区 · 化学

Article

作者: Hegazy, Maha A. ; Saad, Samah S. ; Salem, Maissa Y. ; Elzanfaly, Eman S. ; Abd El Fattah, Laila E.

The introduction of sustainable development concepts to analytical laboratories has recently gained interest, however, most conventional high‐performance liquid chromatography methods do not consider either the effect of the used chemicals or the amount of produced waste on the environment. The aim of this work was to prove that conventional methods can be replaced by greener ones with the same analytical parameters. The suggested methods were designed so that they neither use nor produce harmful chemicals and produce minimum waste to be used in routine analysis without harming the environment. This was achieved by using green mobile phases and short run times. Four mixtures were chosen as models for this study; clidinium bromide/chlordiazepoxide hydrochloride, phenobarbitone/pipenzolate bromide, mebeverine hydrochloride/sulpiride, and chlorphenoxamine hydrochloride/caffeine/8‐chlorotheophylline either in their bulk powder or in their dosage forms. The methods were validated with respect to linearity, precision, accuracy, system suitability, and robustness. The developed methods were compared to the reported conventional high‐performance liquid chromatography methods regarding their greenness profile. The suggested methods were found to be greener and more time‐ and solvent‐saving than the reported ones; hence they can be used for routine analysis of the studied mixtures without harming the environment.

2013-10-01·Indian journal of clinical biochemistry : IJCB

The Impact of Digestive and Colon Drugs on the Human Hormones Profile

Article

作者: Abd-Rabou, Ahmed A ; Ahmed, Hanaa H ; Eskander, Emad F

Hormones play an important role in the digestive system. The main hormones that control digestion are gastrin, secretin, and cholecystokinin. Herein, the current study is concerned with assessing the effect of spasmo canulase and librax drugs on the human hormones profile. Blood samples were withdrawn from adult patients to measure serum FSH, E2, LH, prolactin, progesterone, DHEAS, testosterone, TSH, T3, T4, fasting insulin, and cortisol. All hormone concentrations were determined quantitatively using ELISA procedure. Intriguingly, the present study showed putative changes including thyroid and sex hormonal profiles. Eventually, we concluded that the prospective study could be important in drug dose optimization and providing new medical guidelines to avoid side effects that could harm patients.

2013-06-01·International journal of biomedical science : IJBS

Sensitive method for the quantitative determination of risperidone in tablet dosage form by high-performance liquid chromatography using chlordiazepoxide as internal standard.

Article

作者: Ashour, Safwan ; Kattan, Nuha

A selective, sensitive and simple reversed-phase HPLC method for the determination of risperidone in bulk powder and pharmaceutical formulations was developed and validated. Risperidone can be separated on a Supelcosil LC8 DB column (250 mm × 4.6 mm i.d., 5 μm particle size) at 40°C with a mobile phase of methanol and 0.1 M ammonium acetate pH 5.50 (60:40, v/v), pumped at flow rate 1.0 mL min(-1) and detected at 274 nm. Chlordiazepoxide hydrochloride was used as internal standard. The retention time of risperidone and chlordiazepoxide hydrochloride was found to be 5.89 and 7.65 min, respectively. The validation of the proposed method was carried out for specificity, linearity, accuracy, precision, limit of detection, limit of quantitation and robustness. The linear range was 4.0-275.0 µg mL(-1) (r(2)=0.9998) with limits of detection and quantification values of 0.48 and 1.59 μg mL(-1), respectively. The precision of the method was demonstrated using intra- and inter-day assay RSD values which were less than 3.27%, while the recovery was 99.00-101.12% (n=5). According to the validation results, the proposed method was found to be specific, accurate, precise and could be applied to the quantitative analysis of risperidone in raw material and tablets.

100 项与盐酸氯氮䓬/克利溴胺相关的药物交易

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KEGG	Wiki	ATC	Drug Bank
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适应症	国家/地区	公司	日期
小肠结肠炎	美国	Bausch Health US LLC	1966-09-01
肠易激综合征	美国	Bausch Health US LLC	1966-09-01
消化性溃疡	美国	Bausch Health US LLC	1966-09-01