Pyridoxal phosphate/Lisinopril

A review.MC-1 is a naturally occurring small mol., a metabolite of vitamin B₆, that reduces the damage to the heart caused by ischemia and/or ischemia-reperfusion injury, and has very low toxicity.The safety and efficacy of MC-1 in the treatment of various cardiovascular diseases have been demonstrated in both preclin. and clin. studies.MC-4232 is a combination of MC-1 and lisinopril.Preclin. animal studies and clin. studies in patients with co-existing type 2 diabetes and hypertension have demonstrated a promising safety profile and efficacy for MC-4232 in reducing blood pressure and controlling metabolic dysfunction.Based on the pos. results obtained from phase II clin. studies, both MC-1 and MC-4232 are scheduled to enter phase III studies.