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更新于：2025-03-20

DF-1012

更新于：2025-03-20

概要

概要

基本信息

药物类型

小分子化药

别名

靶点-

作用方式

抑制剂

作用机制

神经肽类抑制剂

治疗领域

呼吸系统疾病免疫系统疾病

在研适应症-

非在研适应症

哮喘咳嗽

原研机构

Dompe Farmaceutici SpA

在研机构-

非在研机构

Dompé SpADompe Farmaceutici SpA

最高研发阶段终止临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C16H20N4O

InChIKeySTKDYVJHOZZQEH-ZSBIGDGJSA-N

CAS号163220-65-3

关联

100 项与 DF-1012 相关的临床结果

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100 项与 DF-1012 相关的转化医学

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100 项与 DF-1012 相关的专利（医药）

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项与 DF-1012 相关的文献（医药）

2007-10-01·International Journal of Mineral Processing

Effect of frothers and solid particles on the rate of water transfer to froth

作者: Janusz S. Laskowski ; Francisco Melo

The effect of flotation frothers on the rate of water transfer to foam/froth was tested.Two-phase experiments with aqueous solutions of the frothers, and three-phase experiments in the presence of solid particles were carried out.It is shown that while the rate of water transfer to foam (two-phase system) is well correlated with the fundamental properties of the frothers, the water transfer rates may be quite different when solid particles are present in the system.These water transfer rates may be further modified if also oily collector (e.g. diesel oil) is used.

2005-10-01·Minerals Engineering

Bubble size distribution in laboratory scale flotation cells

作者: R.A. Grau ; K. Heiskanen

Bubble size was measured in two laboratory scale cells using the HUT bubble size analyzer.The effect of operating conditions on bubble size was investigated.The Sauter mean bubble size was found to vary over the range of 1.2-2.9 mm.The exptl. bubble size distributions were satisfactorily represented by the upper-limit distributions.The frothers were found to have a profound impact on bubble size.It seems that frothers not only prevent bubble coalescence, but they also, affect the bubble break-up process.The air flow rate was also found to have a strong effect on bubble size.The Sauter mean bubble diameter increased as the air flow rate increased.The Sauter mean bubble diameter was found to decrease with increasing impeller speed.The addition of quartz on the other hand was found to increase the size of bubbles, this effect was more evident at solid concentration exceeding 20% (kg/kg).The size of bubbles generated with the multi-mix and free-flow mechanisms were different at similar operating conditions, in a non-coalescing environment.The free-flow design generated broader bubble size distributions than the multi-mix mechanism.

2003-03-01·Organic Process Research & Development

A Practical Synthesis of 7-Azaindolylcarboxy-endo-tropanamide (DF 1012)

作者: Curti, Roberto ; Topai, Alessandra ; Allegretti, Marcello ; Cesta, M. Candida ; Anacardio, Roberto ; Mantovanini, Marco ; Zampella, Giuseppe ; Nano, Giuseppe

An optimized cost-effective synthesis of the new antitussive drug, DF1012 (I), is reported.The new synthetic route to the key intermediate, 7-azaindolyl-3-carboxylic acid, is based on the unusual deprotection step of the 1-tert-butyl-3-cyano-7-azaindole and can also be regarded as a convenient way for the industrial production of the expensive unsubstituted 7-azaindole.The second key intermediate, endo-tropanamine, was obtained in high yield by a novel one-pot stereoselective process using a Pd-catalyzed reductive amination procedure.

100 项与 DF-1012 相关的药物交易

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