茵蔯蒿湯(Yinchenhao Decoction) - 在研适应症：口腔炎，荨麻疹_专利_临床

概要

基本信息

药物类型

中药

别名

Inchinkoto、OHSUGI Inchinkoto Extract Granules G、オースギ茵蔯蒿湯エキスＧ

+ [4]

靶点-

作用方式-

作用机制-

治疗领域

免疫系统疾病口颌疾病皮肤和肌肉骨骼疾病

在研适应症

口腔炎荨麻疹

非在研适应症-

原研机构

Ohsugi Pharmaceutical Co., Ltd.

在研机构

Ohsugi Pharmaceutical Co., Ltd.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1986-12-25),

口腔炎荨麻疹

最高研发阶段(中国)-

特殊审评-

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关联

100 项与茵蔯蒿湯相关的临床结果

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100 项与茵蔯蒿湯相关的转化医学

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100 项与茵蔯蒿湯相关的专利（医药）

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16

项与茵蔯蒿湯相关的文献（医药）

2024-06-01·Journal of oral biosciences

Inhibition of compound action potentials in the frog sciatic nerve by inchinkoto, a traditional Japanese medicine used for oral mucositis

Article

作者: Tamaoki, Sachio ; Taniguchi, Suguru ; Fujita, Tsugumi ; Nishimura, Mayuko

OBJECTIVE:

This study aimed to determine the effects of traditional Japanese (Kampo) medicines used to treat oral mucositis on nerve conduction.

METHODS:

The effects of Kampo medicines, crude drugs, and chemical compounds on compound action potentials (CAPs) were analyzed using extracellular recordings in frog sciatic nerves.

RESULTS:

Among the Kampo medicines, inchinkoto demonstrated the most significant reduction in CAP amplitude, with a half-maximal inhibitory concentration (IC₅₀) of 5.4 mg/mL. Hangeshashinto, shosaikoto, hochuekkito, and juzentaihoto also showed a significant reduction. Regarding inchinkoto, Artemisiae Capillari Spica (artemisia) was the most effective crude drug, with an IC₅₀ of 4.2 mg/mL for CAP amplitude reduction, whereas Gardeniae Fructus (gardenia) exerted no significant effect. However, the combined use of artemisia and gardenia reduced the CAP amplitude more effectively than artemisia alone, indicating a synergistic interaction. The chemical ingredient eugenol from artemisia administered at 1 and 3 mmol/L reduced CAP amplitude, whereas other chemical ingredients administered at 0.1 and 1 mmol/L had no significant effects.

CONCLUSIONS:

Inchinkoto exhibited the most effective reduction in CAP amplitude in the sciatic nerve of frogs, primarily through the action of artemisia, with potential synergistic interaction between artemisia and gardenia.

2021-12-01·Metabolomics : Official journal of the Metabolomic Society

Comprehensive metabolome analysis for the pharmacological action of inchinkoto, a hepatoprotective herbal medicine

Article

作者: Ebata, Tomoki ; Yokoyama, Yukihiro ; Tsuchiya, Kazuaki ; Nagino, Masato ; Yamashita, Hiromasa ; Ohbuchi, Katsuya ; Kushida, Hirotaka

INTRODUCTION:

The precise pharmacological action of inchinkoto (ICKT, Yin-Chen-Hao-Tang in Chinese), a hepatoprotective herbal medicine, on total metabolic pathways has not been well investigated.

OBJECTIVES:

The aim of this study was to explore the serum metabolites reflecting the pharmacological activity of ICKT, and mechanism of action of ICKT using serum metabolome analysis.

METHODS:

54 patients with obstructive jaundice due to malignancies were included in this study. ICKT was administered for 3 days. Serum and bile samples were collected before and 1 h after ICKT administration on days 1 and 4. Serum metabolome analysis including ICKT components were performed.

RESULTS:

The levels of total/direct bilirubin, C-reactive protein, γ-glutamyl transpeptidase, and albumin in the serum were significantly improved after ICKT administration. In the serum metabolome analysis, inosine was the only elevated metabolite on days 1 and 4. Most of the metabolites which were significantly changed after ICKT administration were lipid mediators, and all decreased on day 1. Notably, the levels of many lipid mediators were increased on day 4. The difference in serum aspartic acid 1 h after ICKT administration was significantly correlated with a decrease in the levels of total bilirubin in the serum on day 4.

CONCLUSIONS:

Using metabolome analysis, we demonstrated several metabolic changes that may be associated with the pharmacological mechanisms of ICKT. The biological implications of these metabolites should be further investigated in basic research studies.

2021-08-01·Pediatric surgery international3区 · 医学

The herbal medicines Inchinkoto and Saireito improved hepatic fibrosis via aquaporin 9 in the liver of a rat bile duct ligation model

3区 · 医学

Article

作者: Shin, Ryusuke ; Akiba, Jun ; Yagi, Minoru ; Fukahori, Suguru ; Asagiri, Kimio ; Tanaka, Yoshiaki ; Nishi, Akinori ; Koga, Yoshinori ; Hikida, Shigeki ; Saikusa, Nobuyuki ; Hashizume, Naoki ; Sotogaku, Naoki ; Ishii, Shinji ; Egami, Hideaki

OBJECTIVE:

To determine if the administration of the Japanese herbal medicines Inchinkoto (ICKT) and Saireito (SRT) ameliorate hepatic fibrosis and derangement of hepatocyte aquaporins (AQPs) following bile duct ligation (BDL) in a rat model of obstructive cholestasis.

MATERIALS AND METHODS:

Five groups of Wistar rats were used, and the groups included sham surgery (Sham group), BDL with no treatment (NT group), BDL plus ICKT (ICKT group), BDL plus SRT (SRT group), and BDL plus ICKT and SRT (SRT/ICKT group). Each herbal medicine was administered at 1 g/kg/day on the first postoperative day. The serum levels and various clinical markers were measured with real-time polymerase chain reaction. Staining was used to evaluate the degree of fibrosis and the inflammatory responses.

RESULTS:

Serum aspartate aminotransferase and alanine aminotransferase in the ICKT and SRT/ICKT groups were significantly lower than those in the NT group. NF-κB mRNA expression was significantly decreased in the ICKT group and the SRT/ICKT group compared with the NT group. AQP9 mRNA expression was significantly increased in the ICKT group and the SRT/ICKT group compared with the NT group. The degree of Masson's trichrome staining in the SRT/ICKT group was significantly lower than that in the NT group. The degree of NF-κB staining in the SRT/ICKT group was significantly lower than that in the NT, ICKT, or SRT group.

CONCLUSIONS:

The postoperative administration of ICKT and SRT induced synergistic beneficial effects, resulting in the reduction of hepatic fibrosis via mechanisms involving the inhibition of NF-κB expression and the improvement of AQP9 downregulation.

100 项与茵蔯蒿湯相关的药物交易

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