朝鲜蓟提取物(Artichoke extract)

概要

基本信息

药物类型

中药

别名-

靶点-

作用机制-

治疗领域

肿瘤呼吸系统疾病其他疾病

在研适应症-

非在研适应症

石棉肺肿瘤

原研机构

Aboca S.p.A. Società Agricola

在研机构-

非在研机构

Aboca S.p.A. Società Agricola

最高研发阶段无进展临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与朝鲜蓟提取物相关的临床试验

DRKS00024706 / CompletedN/A

A randomised, placebo-controlled, single blind, monocentric trial to investigate the influence of an artichoke leaf extract for the treatment of non-alcoholic fatty liver disease (NAFLD) - SteatoChoke

开始日期2022-11-01

申办/合作机构

Universität des Saarlandes

NCT02076672 / Completed临床2期IIT

Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed Population (The ABOCA Phase II Trial)

This is a single-arm phase II trial to assess the biological activity (in a sub-cohort using a Simon two-stage Phase II design) and toxicity of Artichoke Whole Phytocomplex Concentrate (WPC). The objective of the study is to explore the potential for a non-toxic phytocomplex extract from the artichoke plant as a chemoprevention agent.

开始日期2019-11-05

申办/合作机构

Ontario Clinical Oncology Group

[+1]

100 项与朝鲜蓟提取物相关的临床结果

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100 项与朝鲜蓟提取物相关的转化医学

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100 项与朝鲜蓟提取物相关的专利（医药）

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24

项与朝鲜蓟提取物相关的文献（医药）

2023-08-07·Medical oncology (Northwood, London, England)

Artichoke as a melanoma growth inhibitor.

Article

作者: Lequio, Marco ; Bai, Qian ; Fang, Yujiang ; Nelson, Christian J ; Mayberry, Trenton G ; Mathew, Annette M ; Wakefield, Mark R ; Deng, Zuliang ; Fajardo, Emerson ; Xiao, Huaping

Melanoma is the most lethal malignancy in skin cancers. About 97,610 new cases of melanoma are projected to occur in the United States (US) in 2023. Artichoke is a very popular plant widely consumed in the US due to its nutrition. In recent years, it has been shown that artichoke shows powerful anti-cancer effects on cancers such as breast cancer, colon cancer, liver cancer, and leukemia. However, there is little known about its effect on melanoma. This study was designed to investigate if artichoke extract (AE) has any direct effect on the growth of melanoma. Clonogenic survival assay, cell proliferation, and caspase-3 activity kits were used to evaluate the effects AE has on cell survival, proliferation, and apoptosis of the widely studied melanoma cell line HTB-72. We further investigated the possible molecular mechanisms using RT-PCR and immunohistochemical staining. The percentage of colonies of HTB-72 melanoma cells decreased significantly after treated with AE. This was paralleled with the decrease in the optic density (OD) value of cancer cells after treatment with AE. This was further supported by the decreased expression of PCNA mRNA after treated with AE. Furthermore, the cellular caspase-3 activity increased after treated with AE. The anti-proliferative effect of AE on melanoma cells correlated with increased p21, p27, and decreased CDK4. The pro-apoptotic effect of AE on melanoma cells correlated with decreased survivin. Artichoke inhibits growth of melanoma by inhibition of proliferation and promotion of apoptosis. Such a study might be helpful to develop a new promising treatment for melanoma.

2022-03-01·Minerva Medica4区 · 医学

Artichoke and bergamot extracts: a new opportunity for the management of dyslipidemia and related risk factors

4区 · 医学

Review

作者: Bellosta, Stefano ; Corsini, Alberto ; Arnaboldi, Lorenzo

The relationship between low LDL-C (cholesterol associated with low-density lipoprotein) and a lower relative risk of developing cardiovascular disease (CVD) has been widely demonstrated. Although from a pharmacological point of view, statins, ezetimibe and PCSK inhibitors, alone or in combination are the front and center of the therapeutic approaches for reducing LDL-C and its CV consequences, in recent years nutraceuticals and functional foods have increasingly been considered as a valid support in the reduction of LDL-C, especially in patients with mild/moderate hyperlipidemia - therefore not requiring pharmacological treatment - or in patients intolerant to statins or other drugs. An approach also shared by the European Atherosclerosis Society (EAS). Of the various active ingredients with hypolipidemic properties, we include the artichoke (Cynara cardunculus, Cynara scolymus) and the bergamot (Citrus bergamia) which, thanks essentially to the significant presence of polyphenols in their extracts, can exert this action associated with a number of other complementary inflammation and oxidation benefits. In light of these evidence, this review aimed to describe the effects of artichoke and bergamot in modifying the lipid and inflammatory parameters described in in vitro, in vivo and clinical studies. The available data support the use of standardized compositions of artichoke and bergamot extracts, alone or in combination, in the treatment of mild to moderate dyslipidemia, in patients suffering from metabolic syndrome, hepatic steatosis, or intolerant to common hypolipidemic treatments.

2022-01-02·Archives of Physiology and Biochemistry3区 · 医学

Evaluation of the anti-atherogenic potential of Egyptian artichoke leaf extract in hypercholesterolemic rats

3区 · 医学

Article

作者: El-Tantawy, Walid Hamdy ; Ahmed, Samah Fathy ; Abd Al Haleem, Ekram Nemr

OBJECTIVESThe current research seeks to assess the anti-atherogenic activity of Egyptian artichoke leaf extract in hypercholesterolemic rats.MATERIALS AND METHODSMale albino rats were categorized into five groups; control group, high cholesterol diet treated group (HCD), HCD + low dose of artichoke, HCD + high dose of artichoke and HCD + Atorvastatin.RESULTSBoth doses of artichoke extract significantly decreased the concentration of serum cholesterol, triglycerides, and LDL-C in HCD rats as compared to that of their matching controls, p < .05. The treatment with artichoke led to the inhibition of the liver hydroxymethylglutaryl-CoA (HMG-CoA) reductase. Besides, the extract was proven to be cardioprotective effective by increasing antioxidant activity. The effect of the highest dose of artichoke was more apparent than the effect of the lowest one. The biochemical data was reinforced by the histopathological studies.DISCUSSION AND CONCLUSIONArtichoke may act as a natural source for the elimination of cardiovascular ailments.

100 项与朝鲜蓟提取物相关的药物交易

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