Cardiovascular Fixed Dose Combination Pill: A Pharmacodynamic Interaction Study to Evaluate the Effect of a Fixed Dose Combination of Acetylsalicylic Acid, Simvastatin and Ramipril (Cardiovascular Fixed Dose Combination Pill) on Blood Pressure

The purpose of this study is to compare the effect on systolic pressure of the 3 drugs given together in the cardiovascular combination pill (acetylsalicylic acid, simvastatin, and ramipril) to the effect on systolic pressure of ramipril given alone.

开始日期2009-10-01

申办/合作机构

Ferrer Internacional SA

NCT00959101 / Completed临床1期

A Randomised, Single-Blind, Three-Period Crossover Study Examining the Single Dose Pharmacokinetics of Concomitantly Administered Repaglinide and Metformin Versus Combination Tablet Dosing (NN4440) in Fed Healthy Male Volunteers

This trial is conducted in Asia. The aim of this clinical trial is to investigate the bioequivalence of repaglinide and metformin combination tablet versus repaglinide and metformin as coadministered tablets after meal.
The trial is designed as a three-period, six-sequence, single-dose, crossover pharmacokinetic trial where the trial participant is randomised to one of six possible treatment periods (Williams design). The trial participant will receive one single dose of each trial product in varying order.

开始日期2009-08-01

申办/合作机构

Novo Nordisk A/S

NCT00399711 / Completed临床3期

Repaglinide and Metformin Combination Tablet (NN4440) in a TID Regimen Compared to a BID Regimen and BID Avandamet in Subjects With Type 2 Diabetes: A Twenty-Six Week, Open-Label, Multicenter, Randomized, Parallel Group Trial to Investigate Efficacy and Safety

This trial is conducted in the United States of America (USA). This trial compares the changes in HbA1c after 26 weeks of repaglinide and metformin fixed dose combination tablet given as twice daily versus three times daily regimens or versus twice daily rosiglitazone and metformin fixed dose combination tablet in subjects with type 2 diabetes currently on monotherapy.

开始日期2006-11-01

申办/合作机构

Novo Nordisk A/S

100 项与苯海拉明水杨酸盐/二丙茶碱相关的临床结果

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100 项与苯海拉明水杨酸盐/二丙茶碱相关的转化医学

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100 项与苯海拉明水杨酸盐/二丙茶碱相关的专利（医药）

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项与苯海拉明水杨酸盐/二丙茶碱相关的文献（医药）

2017-04-01·Human Cell3区 · 生物学

Biodistribution of diphenhydramine in reproductive organs in an overdose case

3区 · 生物学

Article

作者: Ishikawa, Takaki ; Michiue, Tomomi ; Chen, Jian-Hua ; Oritani, Shigeki ; Tani, Naoto

Motion sickness medications such as Travelmin^® prescribed in Japan include diphenhydramine (DPH), dyphylline, diphenidol, and/or caffeine. Herein, we report a patient who died due to rhabdomyolysis after ingesting a DPH containing motion sickness medication. A Japanese male in his 30 s reported missing after going out for a drive early in the morning was found dead in his car in the evening of the same day. An autopsy showed moderate edema, congestion, and several petechiae in both lungs. The brain was congested and edematous with no atherosclerosis of cerebral arteries. The prostate and both testes were slightly edematous. Gastric contents included approximately 15 mL of dark-brown fluid without tablets or food residue. Toxicological examination showed that blood DPH levels in all tissues were between 4.90 and 7.27 μg/mL, which represented toxic to lethal levels. DPH (μg/mL) levels were approximately 3-9 times higher in the prostate (73.42) and testes (left, 28.23; right, 30.09) than those in all regions of the brain (range 7.75-12.33). Blood dyphylline, diphenidol and caffeine levels in reproductive organs reached high, but not toxic levels. In conclusion, DPH, dyphylline, diphenidol, and caffeine levels were higher in reproductive organs such as the prostate and testes than in the central nervous system and heart. As we determined in this case, motion sickness medications might accumulate in reproductive organs. Thus, further examination of tissue biodistribution of DPH, dyphylline, diphenidol, and caffeine is necessary to assess their potential long-term effects in these sites.

2008-01-01·Clinical Toxicology3区 · 医学

Fatal diphenhydramine poisoning with increased vascular permeability including late pulmonary congestion refractory to percutaneous cardiovascular support

3区 · 医学

Article

作者: Yoshito Kamijo ; Katsuyoshi Kurihara ; Kazui Soma ; Chie Sato

BACKGROUNDFatal adult cases of acute diphenhydramine poisoning are extremely rare.CASE REPORTTransiently awakened by a roommate, a 39-year-old man admitted to massive ingestion of an over-the-counter drug containing diphenhydramine salicylate. On admission the patient was semicomatose and developed circulatory collapse with severe dehydration and metabolic acidosis, followed by status epilepticus. Despite extensive life support measures including percutaneous cardiopulmonary support, vascular permeability progressively increased, with pulmonary congestion as well as peripheral vasodilation evident as rubedo. The patient died without improvement of cardiac function. Subsequent diphenhydramine assays in serum specimens obtained at the time of delayed congestive symptoms indicated decreases in drug concentration to a sublethal amount.DISCUSSIONWe suspect that metabolites of diphenhydramine with histamine-agonist actions contributed to the development of fatal delayed symptoms.

100 项与苯海拉明水杨酸盐/二丙茶碱相关的药物交易

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适应症	国家/地区	公司	日期
梅尼埃病	日本	Sannova KK	1960-08-08
晕动病	日本	Sannova KK	1960-08-08

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01005290 (CTgov)	临床2期	高血压	38	Combination pill (Combination Pill)	遞壓夢顧構鹽選鏇壓積(淵襯淵壓觸鏇遞夢廠築) = 膚廠鏇選範範窪憲餘觸製糧襯鬱夢鬱鏇糧糧蓋 (夢簾範範繭鹽膚壓廠醖, 壓窪積網觸築膚艱願繭 ~ 鏇選繭壓願壓選醖獵網) 更多	-	2012-07-26
				Ramipril (Ramipril)	遞壓夢顧構鹽選鏇壓積(淵襯淵壓觸鏇遞夢廠築) = 繭構窪鹹鏇醖醖壓繭築製糧襯鬱夢鬱鏇糧糧蓋 (夢簾範範繭鹽膚壓廠醖, 願廠艱夢網鹽鏇艱壓鹹 ~ 餘餘憲遞鹽憲襯願夢艱) 更多