Efficacy and Safety of a Low-FODMAP Diet in Combination with a Gluten-Free Diet for Adult Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis

Article

作者: Xu, Yang ; Zhang, Jing ; Yu, Ping ; Zhang, Yu ; Hang, Jun ; Lu, Xiao Yun ; Xu, Yan

BACKGROUNDCommon gastrointestinal disease irritable bowel syndrome (IBS) is marked by symptoms like changed bowel habits, bloating, and stomach ache. A low-FODMAP combined gluten-free diet (LF-GFD) has been suggested as a possible therapy for IBS symptoms management.OBJECTIVEThis study sought to investigate whether a LF-GFD would help patients with IBS.METHODSStrict inclusion and exclusion criteria from internet databases helped to identify clinical studies evaluating the intervention of LF-GFD in the treatment of IBS patients. Using measurements including the visual analog scale (VAS) for bloating and pain, the IBS symptom severity scale (IBS-SSS), and IBS quality of life (IBS-QoL), the main results evaluated were the efficacy of LF-GFD in reducing IBS symptoms. Furthermore assessed were the psychological impacts of LF-GFD utilizing the self- rating depression scale (SDS) and self- rating anxiety scale (SAS).RESULTSA total of 437 patients (221 on LF-GFD diet and 216 on GFD) were involved in 4 randomized controlled trials and 4 cohort studies. The combined results indicated that LF-GFD reduced the VAS bloating ratings (RR = - 0.58, 95%CI - 0.92-0.23, P = 0.0010, I2 = 83%) and the VAS pain scores (RR = - 0.42, 95%CI - 0.66-0.19, P = 0.005, I2 = 58%). In addition, LF-GFD indicated a substantial enhancement in IBS-SSS scores (MD = - 1.42, 95%CI - 2.74-0.10, P = 0.03, I2 = 24%) and IBS-QoL ratings (MD = 3.75, 95%CI 0.98-6.53, P = 0.008, I2 = 33%). Moreover, the LF-GFD group showed a substantial drop in SDS (MD = - 2.56, 95%CI - 3.38-1.74, P < 0.00001, I2 = 65%) and SAS (MD = - 4.30, 95%CI - 6.53-2.24, P < 0.0001, I2 = 0%) scores compared to the GFD group.CONCLUSIONLF-GFD therapy significantly enhances clinical symptoms and reduces anxiety and depression in individuals diagnosed with irritable bowel syndrome.

2024-09-29·Cureus

Beyond the Grain: Navigating the Intersection of Gluten-Free Diets, Celiac Disease, and Cardiovascular Health

Review

作者: Kesselman, Marc M ; Davis, Kelley L ; Saikaly, Rosie ; Delladio, William ; Barroca, Crystal ; Akel, Miis ; Kaldas, Paul

Celiac disease (CD) is a complex autoimmune disorder triggered by gluten exposure in genetically susceptible individuals. This scoping review explores the intricate relationship between CD and cardiovascular manifestations, aiming to understand the impact of gluten-free diets (GFD) on cardiac health. A comprehensive search resulted in four pertinent studies revealing structural and functional abnormalities in the cardiovascular system of untreated CD patients. Among patients who did not adhere to a GFD, electrocardiogram abnormalities such as prolonged QT intervals and increased predisposition to arrhythmias were noted. Studies identified a significant prevalence of CD in patients with dilated cardiomyopathy or myocarditis, suggesting a potential association. GFD and immunosuppression were shown to improve cardiac function and reduce arrhythmias in CD patients exhibiting cardiovascular manifestations. However, limitations such as small sample sizes and incongruous cohorts make it difficult to assess the direct impact of GFD interventions on cardiac health. Future research should prioritize larger, longitudinal studies to fully understand mechanisms and treatment strategies. This review emphasizes the intricate interplay between CD and cardiac health, emphasizing the importance of early detection, comprehensive management, and further research for optimal clinical outcomes.

2024-09-01·Cureus

Assessing the Impact of a Gluten-Free Diet on Celiac Disease Symptoms in Children: A Comprehensive Review.

Review

作者: Koneru, Hema Manvi ; Bandi, Venkata Varshitha ; Sarwar, Hooria ; Tarar, Pakeeza ; Malasevskaia, Iana ; Sinha, Mohit ; Maged, Rafik

Celiac disease, a serious autoimmune disease, is triggered by the ingestion of gluten. It is associated with many gastrointestinal and extraintestinal symptoms. The cornerstone of treatment is a strict gluten-free diet (GFD). This paper collected studies that were screened between the 15th and 25th of June 2024 and were searched for from many databases and registers, including PubMed, Medline, ClinicalTrials.gov, Cochrane Library, Europe PMC, and EBSCO Open Dissertations. We have included the 12 most relevant studies that examined the effects of GFD adherence among pediatric patients with celiac disease. Evidence suggests that a GFD caused notable improvements in liver function, growth metrics, and quality of life indices. Extraintestinal symptoms such as cardiac dysfunctions and obstructive sleep apnea also showed compelling improvement. We conclude that there are substantial advantages of a GFD in children with celiac disease and call for the need for personal nutritional support to address nutritional deficiencies and long-term studies and comprehensive strategies to optimize treatment outcomes and improve the quality of life for affected children.

100 项与 Fcgamma1-Fel d1 human-cat fusion protein vaccine (Tunitas Therapeutics) 相关的药物交易

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