BE-54238A(BE-54238A) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名

BE-54238B

靶点-

作用方式-

作用机制-

治疗领域

肿瘤

在研适应症-

非在研适应症

肿瘤

原研机构

MSD (Japan) Co., Ltd.

在研机构-

非在研机构

Waseda UniversityMSD (Japan) Co., Ltd.

权益机构-

最高研发阶段无进展药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C22H23NO6

InChIKeyAWMWNWIBOOYESP-UHFFFAOYSA-N

CAS号205433-26-7

关联

100 项与 BE-54238A 相关的临床结果

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100 项与 BE-54238A 相关的转化医学

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100 项与 BE-54238A 相关的专利（医药）

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3

项与 BE-54238A 相关的文献（医药）

2022-02-25·Journal of Natural Products2区 · 生物学

Glenthenamines A–F: Enamine Pyranonaphthoquinones from the Australian Pasture Plant Derived Streptomyces sp. CMB-PB042

2区 · 生物学

Article

作者: Bernhardt, Paul V. ; Salim, Angela A. ; Cui, Hui ; Wu, Taizong ; Capon, Robert J. ; Khalil, Zeinab G.

Chemical investigations into solid phase cultivations of an Australian sheep station pasture plant derived Streptomyces sp. CMB-PB042 yielded the rare enamine naphthopyranoquinones BE-54238A (1) and BE-54238B (2), together with four new analogues, glenthenamines B-D (4-6) and F (8), and two handling artifacts, glenthenamines A (3) and E (7). Single-crystal X-ray analyses of 1 and 2 resolved configurational ambiguities in the scientific literature, while detailed spectroscopic analysis and biosynthetic considerations assigned structures inclusive of absolute configuration to 3-8. We propose a plausible sequence of biosynthetic transformations linking structural and configurational features of 1-8 and apply a novel Schiff base "fishing" approach to detect a key deoxyaminosugar precursor. These enamine naphthopyranoquinones disclose a new P-gp inhibitory pharmacophore capable of reversing doxorubicin resistance in P-gp overexpressing colon carcinoma cells.

2005-12-01·Chemical Reviews1区 · 化学

Total Synthesis of Selected Bioactive Natural Products: Illustration of Strategy and Design

1区 · 化学

Review

作者: Tatsuta, Kuniaki ; Hosokawa, Seijiro

A review of total synthesis of bioactive natural products including cochleamycin A, tetracycline, nanaomycin D, BE-54238B, sideroxylonal, lymphostin, rosmarinecine, thienamycin, trichostatin D.

2004-01-01·The Journal of Antibiotics4区 · 医学

The First Total Synthesis of a Pyranonaphthoquinone Antitumor, BE-54238B

4区 · 医学

Letter

作者: Yoshikazu Suzuki ; Takashi Ogura ; Kuniaki Tatsuta ; Masazumi Kojima ; Tomokazu Hirabayashi

Total asym. synthesis and absolute configuration of BE 54238B (I) was reported.

100 项与 BE-54238A 相关的药物交易

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