Although positive oral contrast agents are used for the majority of abdominopelvic CT scans in the United States, the quality of bowel opacification has not been compared between the three major classes of positive oral contrast material (barium sulfate, ionic iodinated contrast material, and non-ionic iodinate contrast material). This is a retrospective single institution study of clinical records to show whether the uniformity of bowel opacification is different between the three main types of positive CT oral contrast material used in the United States (Barium sulfate, Diatrizoate, and Iohexol). The investigators will retrospectively identify 250 patients each who received oral barium sulfate, diatrizoate, and iohexol for CT scanning of the abdomen and pelvis (total 750 patients) and assess the quality of bowel lumen opacification by the positive oral contrast agents.

开始日期2015-09-01

申办/合作机构

The University of California, San Francisco

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100 项与泛影酸钠相关的临床结果

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100 项与泛影酸钠相关的转化医学

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100 项与泛影酸钠相关的专利（医药）

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1,146

项与泛影酸钠相关的文献（医药）

2024-11-01·Internal Medicine

Tapeworm Infection Diagnosed after <i>Campylobacter jejuni</i>-induced Enteritis

Article

作者: Kamiyama, Naganori ; Kagoshima, Yomei ; Tsutsumi, Koshiro ; Takahashi, Haruhiko ; Ogawa, Ryo ; Hasegawa, Hideo ; Kodama, Masaaki ; Shimomori, Yuta ; Ozaka, Sotaro ; Mizukami, Kazuhiro ; Kobayashi, Takashi ; Murakami, Kazunari ; Sachi, Nozomi ; Hirashita, Yuka ; Fukuda, Kensuke ; Soma, Ryusuke ; Fukuda, Masahide

A 35-year-old man with fever and diarrhea visited our hospital because of white string-like fecal excretion. Based on a morphological examination of the excreted object, a Diphyllobothrium infection was suspected. Additionally, Gram staining of a fecal sample revealed Campylobacter infection. After the intraduodenal administration of meglumine/diatrizoate sodium, the tapeworm was excreted. A polymerase chain reaction-based DNA sequence analysis demonstrated that the tapeworm excreted in this case was Diphyllobothrium nihonkaiensis. This report presents a rare case of coinfection with Diphyllobothrium nihonkaiensis and Campylobacter jejuni. Therefore, it is important to consider the coexistence of other intestinal infections when diagnosing parasitic infections in patients with fever.

2024-09-01·Chemosphere

Temperature-driven and discharge-driven variability of organic micropollutants in a large urban river and its implications for risk-based monitoring

Article

作者: Vargha, Márta ; Erdélyi, Norbert ; Engloner, Attila ; Gere, Dóra

Urban rivers are exposed to an increasing load of organic micropollutants from wastewater effluent posing an ecological as well as public health hazard. One-off surveys can capture a snapshot of the pollution profile but fail to reveal the full scale of spatial and temporal heterogeneity. In the present study, 41 micropollutants (non-steroid anti-inflammatory drugs (NSAID), antihypertensives, antiepileptic, antidiabetic, antibiotics, iodinated contrast media (ICM), corrosion inhibitors, pesticides) were monitored every two weeks for one-year upstream and downstream of the Budapest metropolitan area in Danube River (336 samples total). ICMs, benzotriazoles and metamizole degradation products were detected in highest concentration regularly exceeding 100 ng/L. Median concentration of other pharmaceuticals ranged from <1 to 26 ng/L, while pesticides were typically below 10 ng/L. Variability of micropollutant concentration was primarily temporal, exhibiting two different patterns: (1) inverse correlation to river discharge, observed for corrosion inhibitors and carbamazepine (r = -0.505 to -0.665) or (2) inverse correlation to water temperature, observed primarily for ICMs, antihypertensives and antibiotics, r = -0.654 to -0.904). Temperature dependence was also significant after correcting for river discharge. Relative increase of pharmaceuticals was 2-134% after the metropolitan area, partially explained by emission estimates calculated from retail data and metabolization rates. The concentration of five ICMs (iopamidol in 100, iodixanol in 96, diatrizoate in 22, iomeprol in 21 and iohexol 13% of the samples) and two NSAIDs (ibuprofen and diclofenac (in 31.5 and 23% of the samples) exceeded the predicted no environmental effect concentration, posing a risk to algae (HQ = 1.2-6) and fish (HQ = 1.4-1.9), respectively. Results suggest that risk-based monitoring and risk management efforts should focus on ICMs, NSAIDs and industrial chemicals, taking into account that sampling in cold periods and during low flow provides the worst-case estimates.

2024-03-01·The Journal of Allergy and Clinical Immunology: In Practice

Skin Test Reactivity Patterns in Patients Allergic to Iodinated Contrast Media: A Refined View

Article

作者: Schrijvers, Rik ; Ciocănea-Teodorescu, Iuliana ; Forsea, Ana-Maria ; Demoly, Pascal ; Molinari, Nicolas ; Ghiordanescu, Ileana-Maria ; Motei, Cezara ; Chiriac, Anca Mirela

BACKGROUNDTwo-dimensional (2D) classifications of iodinated contrast media (ICM) are insufficient to explain the observed skin test (ST) reactivity patterns in patients with drug hypersensitivity reactions (DHRs) to ICM.OBJECTIVETo refine the current view on allergic DHRs to ICM by analyzing ST reactivity patterns in patients with previous reactions to ICM.METHODSPatients with a history of DHR to ICM and positive STs, who presented at the University Hospital of Montpellier between 2004 and 2022, were included in the study. The relative difference between every two ICM products was measured by Manhattan distance and odds ratios were computed for all pairs of products in the immediate reaction (IR) and non-immediate reaction (NIR) ST groups.RESULTSA total of 181 patients were included in the study. Odds ratio analysis identified significant associations between classical cross-reactive ICM, such as iohexol-ioversol, iohexol-iomeprol, iomeprol-ioversol, and iohexol-iodixanol in the IR ST group and iohexol-ioversol, iopromide-iohexol, and iomeprol-ioversol in the NIR ST group. We also identified uncommon associations, such as ioxitalamate-amidotrizoate in the IR ST group and amidotrizoate-iopamidol and amidotrizoate-ioxitalamate in the NIR ST group. The results were reflected by the Manhattan distance, which suggested the existence of clusters containing the same classically associated ICM as well as uncommon associations, which we hypothesize to be related to similarities in the 3D structure of the respective ICM.CONCLUSIONSCurrent chemical (2D) classifications cannot explain all observed ST reactivity patterns. Whether the 3D structure can be integrated into the current classifications to interpret the observed ST reactivity patterns and predict tolerance to alternative ICM requires further research.

100 项与泛影酸钠相关的药物交易

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