Background: Engagement in food and alcohol disturbance (FAD; e.g., restricting caloric intake in the context of using alcohol to quicken/increase intoxication [FAD-intoxication] and/or to offset calories consumed from alcohol [FAD-calories]) confers risk to college students. Much research suggests that students overestimate the frequency of high-risk drinking among their peers, leading to greater participation in personal high-risk drinking. However, limited work has examined social norms related to FAD and their association with FAD behaviors. Objectives: The present study investigated: (a) whether normative misperceptions exist for FAD, (b) whether FAD norms are associated with FAD behaviors, and (c) whether gender moderates the association between FAD norms and FAD behaviors. Participants were 1,499 college students from six universities who consumed alcohol in the last month and identified as a woman or man. A plurality of participants identified as being White, non-Hispanic (59.5%) and female (68.1%), with a mean age of 19.66 (SD = 2.09) years. Results: Analyses revealed that students overestimated the frequency and approval of both FAD-intoxication and FAD-calories behaviors among their same-gender peers. Notably, these misperceptions were greater for FAD participators compared to FAD abstainers. Moreover, the associations between FAD norms and FAD behaviors were generally stronger for women compared to men. Conclusions: Our preliminary findings identify social norms as a potential target for interventions aiming to reduce FAD among college students. Further, our results provide preliminary evidence that college women, especially those who engage in FAD, may reap the greatest benefit from interventions targeting normative misperceptions (e.g., personalized normative feedback) related to FAD.

2024-09-01·Sports Medicine

Mitochondria as Nutritional Targets to Maintain Muscle Health and Physical Function During Ageing

Review

作者: Broome, Sophie C ; Whitfield, Jamie ; Hawley, John A ; Karagounis, Leonidas G

AbstractThe age-related loss of skeletal muscle mass and physical function leads to a loss of independence and an increased reliance on health-care. Mitochondria are crucial in the aetiology of sarcopenia and have been identified as key targets for interventions that can attenuate declines in physical capacity. Exercise training is a primary intervention that reduces many of the deleterious effects of ageing in skeletal muscle quality and function. However, habitual levels of physical activity decline with age, making it necessary to implement adjunct treatments to maintain skeletal muscle mitochondrial health and physical function. This review provides an overview of the effects of ageing and exercise training on human skeletal muscle mitochondria and considers several supplements that have plausible mechanistic underpinning to improve physical function in ageing through their interactions with mitochondria. Several supplements, including MitoQ, urolithin A, omega-3 polyunsaturated fatty acids (n3-PUFAs), and a combination of glycine and N-acetylcysteine (GlyNAC) can improve physical function in older individuals through a variety of inter-dependent mechanisms including increases in mitochondrial biogenesis and energetics, decreases in mitochondrial reactive oxygen species emission and oxidative damage, and improvements in mitochondrial quality control. While there is evidence that some nicotinamide adenine dinucleotide precursors can improve physical function in older individuals, such an outcome seems unrelated to and independent of changes in skeletal muscle mitochondrial function. Future research should investigate the safety and efficacy of compounds that can improve skeletal muscle health in preclinical models through mechanisms involving mitochondria, such as mitochondrial-derived peptides and mitochondrial uncouplers, with a view to extending the human health-span.

2024-07-02·Nutritional Neuroscience

Iron and n-3 fatty acid depletion, alone and in combination, during early development provoke neurochemical changes, anhedonia, anxiety and social dysfunction in rats

Article

作者: Zandberg, Lizelle ; Harvey, Brian H ; Kemp, Erna T ; Baumgartner, Jeannine ; Smuts, Cornelius M

Objectives: Both iron and omega-3 (n-3) fatty acids (FA) play important roles in the development and functioning of the brain. We investigated the effects of n-3 FA and iron deficiencies, alone and in combination, during early development on behaviour and brain monoamines in rats. Methods: Using a 2-factorial design, female Wistar rats were randomly allocated to one of four diet groups: Control, n-3 FA deficient (n-3 FAD), iron deficient (ID), or n-3 FAD + ID. Females received these diets throughout mating, pregnancy and lactation. Offspring (n = 24/group; male:female = 1:1) continued on the same diet until post-natal day 42-45, and underwent a sucrose preference test (SPT), novel object recognition test, elevated plus maze (EPM) and social interaction test (SIT). Results: ID offspring consumed less sucrose in the SPT and spent more time in closed arms and less time in open arms of the EPM than non-ID offspring. In female offspring only, ID and n-3 FAD reduced time approaching and together in the SIT, with an additive effect of ID and n-3 FAD for even less time approaching and spent together in the n-3 FAD + ID group compared to controls. ID offspring had higher striatal dopamine and norepinephrine and lower frontal cortex dopamine concentrations. N-3 FAD and ID affected frontal cortex serotonin concentrations in a sex-specific manner. Conclusions: Our results suggest that ID and n-3 FAD during early development provoke anhedonia, anxiety and social dysfunction in rats, with potential additive and attenuating effects when combined. These effects may in part be attributed to disturbances in brain neurochemistry and may be sex-specific.

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