The efficacy and safety of pure Saw palmetto (Serenoa repens) extract lotion in Androgenetic Alopecia: An Open-labelled Quasi Experimental Clinical Study

开始日期2023-08-15

申办/合作机构

Mae Fah Luang University

NCT01585246 / Completed临床1/2期IIT

Saw Palmetto Use During Radiation Therapy for Symptom Management Among Prostate Cancer Patients

The aim of this study is to test whether Saw Palmetto, is useful in preventing or reducing the side effects for men undergoing radiation therapy for prostate cancer. Urinary symptoms will be recorded each week, as well as assessment of quality of life through: 1) Physical Well-Being 2) Social/Family Well-being 3) Emotional Well-Being, and 4) Functional Well-Being.

开始日期2011-10-01

申办/合作机构

Michigan State University

NCT00603304 / Completed临床3期IIT

Complementary and Alternative Medicine for Urological Symptoms (CAMUS)

The CAMUS trial will test Saw palmetto in about 369 men. Men who decide to be part of the CAMUS trial will be given one out of two possible treatments at random. One out of every two men would get an inactive placebo treatment. One out of every two men would get Saw palmetto pills.
This kind of scientific study is the best way to find out if the plant extracts really work to prevent men with benign prostatic hyperplasia (BPH) from getting worse. During the study, men will not know which of the two treatments they are assigned to. They will be followed very closely by a study team every 12 weeks to see how they are doing. Men in the CAMUS trial will be studied over 72 weeks. Tests and all medications needed as part of the study will be provided at no charge to the participant. Participants will be responsible for all other costs not associated with the study tests and medications. All information on study participants will be held in the strictest confidence and no one would have access to patient information other than the required authorized health care and research personnel.

开始日期2008-02-01

申办/合作机构

The University of Alabama at Birmingham

[+14]

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100 项与 PPRT-321 相关的转化医学

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147

项与 PPRT-321 相关的文献（医药）

2024-01-02·The world journal of men's health

Serenoa repens for the Treatment of Lower Urinary Tract Symptoms Due to Benign Prostatic Enlargement: An Updated Cochrane Review.

Article

作者: Juan Víctor Ariel Franco ; Leonel Fabrizio Trivisonno ; Nadia Sgarbossa ; Gustavo Ariel Alvez ; Cecilia Fieiras ; Camila Micaela Escobar Liquitay ; Jae Hung Jung

PURPOSE:

To assess the effects of Serenoa repens in the treatment of men with lower urinary tract symptoms (LUTS) consistent with benign prostatic hyperplasia (BPH).

MATERIALS AND METHODS:

We performed a comprehensive search using multiple databases up to September 2022 with no language or publication status restrictions. We included parallel-group randomized controlled trials of participants with BPH who were treated with Serenoa repens or placebo/no treatment. We used standard Cochrane methods, including a GRADE assessment of the certainty of the evidence (CoE).

RESULTS:

We included 27 studies involving a total of 4,656 participants. Serenoa repens results in little to no difference in urologic symptoms at short-term follow-up (International Prostate Symptom Score [IPSS]: mean difference [MD] -0.90, 95% confidence interval [CI] -1.74 to -0.07; I²=68%; 9 studies, 1,681 participants; high CoE). Serenoa repens results in little to no difference in the quality of life at short-term follow-up (high CoE). Serenoa repens probably results in little to no difference in adverse events (moderate CoE). Different phytotherapeutic agents that include Serenoa repens may result in little to no difference in urologic symptoms compared to placebo at short-term follow-up (IPSS: MD -2.41, 95% CI -4.54 to -0.29; I²=67%; 4 studies, 460 participants; low CoE). We are very uncertain about the effects of these agents on quality of life (very low CoE). These agents may result in little to no difference in the occurrence of adverse events (low CoE).

CONCLUSIONS:

Serenoa repens alone provides little to no benefits for men with LUTS due to benign prostatic enlargement. There is more uncertainty about the role of Serenoa repens in combination with other phytotherapeutic agents.

2023-12-01·Cureus

Pharmacological Approaches in Managing Symptomatic Relief of Benign Prostatic Hyperplasia: A Comprehensive Review.

Review

作者: Collyn O'Quin ; Kathryn L White ; John R Campbell ; Sarah H Myers ; Shilpadevi Patil ; Debbie Chandler ; Shahab Ahmadzadeh ; Giustino Varrassi ; Sahar Shekoohi ; Alan D Kaye

Benign Prostatic Hyperplasia (BPH) is a prevalent condition that affects aging men, leading to the development of lower urinary tract symptoms (LUTS) and potentially severe complications such as complete obstruction. The management of BPH typically involves the use of medications from different classes, including alpha-1 antagonists, 5-alpha reductase inhibitors, and anticholinergics. Combination therapy utilizing drugs from different classes can also effectively manage the BPH-LUTS complex. Recent research has revealed that phosphodiesterase 5 (PDE5) inhibitors, including Tadalafil and Sildenafil, are highly effective in treating LUTS associated with BPH. Tadalafil as a monotherapy has recently been shown to significantly improve LUTS in BPH patients. Additionally, the use of herbal remedies as a treatment option for BPH has also been widely debated. Previous research suggests that saw palmetto can reduce BPH symptoms through several proposed mechanisms, but recent trials have found inconsistencies in its efficacy. In this literature review, we conducted an extensive PubMed database search to provide current and comprehensive insights into BPH treatment options. This review comprehensively evaluates available treatments for managing BPH, highlighting the effectiveness of different classes of medications and combination therapies in managing associated symptoms. The present investigation also discusses recent research on the efficacy of PDE5 inhibitors in treating LUTS associated with BPH and the uncertain efficacy of herbal remedies. The insights provided by this study can guide healthcare professionals in making informed decisions about managing BPH, ultimately improving patient outcomes.

2023-07-18·Phytotherapy research : PTR

Suspected adverse reactions to medications and food supplements containing Serenoa repens: A worldwide analysis of pharmacovigilance and phytovigilance spontaneous reports.

Article

作者: Giada Crescioli ; Valentina Maggini ; Emanuel Raschi ; Laura Augusta Gonella ; Nicoletta Luxi ; Ilaria Ippoliti ; Valentina Di Giovanni ; Roberto Bonaiuti ; Niccolò Firenzuoli ; Eugenia Gallo ; Francesca Menniti-Ippolito ; Ugo Moretti ; Gianluca Trifirò ; Alfredo Vannacci ; Fabio Firenzuoli ; Niccolò Lombardi

The safety of Serenoa repens (SR)-containing products was evaluated conducting a retrospective worldwide analysis of pharmaco- and phytovigilance report forms of suspected adverse reactions (SARs) collected up to 31 January 2022. Multivariate logistic regression was performed to estimate the odds ratios (ORs) of serious SAR. A total of 1810 report forms were analysed; 92% of subjects were males, with a median age of 69 years; 44% of cases were defined as serious. Subjects exposed to dietary supplements had a higher risk of developing serious SARs (OR: 1.60 [95% CI: 1.20-2.15]), as subjects exposed to 2-5 (OR: 1. 83 [95% CI: 1.30-2.58]) or more than 5 (OR: 3.45 [95% CI: 2.36-5.06]) suspect/interacting products. The probability of experiencing serious SAR was higher for subjects exposed to concomitant products (OR: 1.55 [95% CI: 1.15-2.08]), to more than four active compounds (OR: 4.38 [95% CI: 3.21-5.99]) and to SR for more than 14 days (OR: 1.89 [95% CI: 1.10-3, 22]), and lower for subjects exposed to higher doses of SR (OR: of 0.34 [95% CI: 0.20-0.58]). This evidence improves awareness on safety of SR containing products, suggesting the need of a further update of periodic reviews by national and international regulatory agencies.

项与 PPRT-321 相关的新闻（医药）

2024-02-06

·PRNewswire

Dermal Repair Complex from Beverly Hills MD Can Help Nourish Dry Skin This Winter

A Dietary Supplement That Supports Visibly Firmer and More Lifted-Looking Skin, A Reduced Appearance of Wrinkles, and Enhanced Radiance BEVERLY HILLS, Calif., Feb. 6, 2024 /PRNewswire/ -- As Winter temperatures begin to drop, many of us find that the cold weather can bring on a set of challenges, particularly for our skin. The harsh winter conditions often leave us grappling with dry skin, causing plump skin cells to shrivel and potentially leading to fine lines and wrinkles. Continue Reading Beverly Hills MD Dermal Repair Complex is a dietary supplement designed to revitalize the look of skin from the inside out. Formulated to address the key causes of dermal breakdown, this supplement aims to help visibly firm and lift the skin, reduce the appearance of wrinkles, enhance radiance, and contribute to a significantly younger and healthier overall appearance. In combating the effects of winter-induced dryness, skincare experts Dr. John Layke and Dr. Payman Danielpour emphasize the importance of constant moisturizing and the potential benefits of dietary supplements. One such supplement is the Beverly Hills MD Dermal Repair Complex. Beverly Hills MD Dermal Repair Complex is a dietary supplement designed to revitalize the look of skin from the inside out. Formulated to address the key causes of dermal breakdown, this supplement aims to help visibly firm and lift the skin, reduce the appearance of wrinkles, enhance radiance, and contribute to a significantly younger and healthier overall appearance. As we bid farewell to winter, it's time to consider incorporating such skincare solutions to help rejuvenate and nourish the skin for the upcoming seasons.†* What is Beverly Hills MD Dermal Repair Complex? Beverly Hills MD Dermal Repair Complex is a dietary supplement crafted with an advanced blend of scientifically-backed nutrients. This formula is designed to aid your body in reducing visible signs of aging by combating the impact of skin-aging hormones, reduced body moisture, and collagen loss. The ingredients in Beverly Hills MD Dermal Repair Complex, including hydrolyzed collagen, hyaluronic acid, MSM, and vitamins A and B, collaborate to help diminish the appearance of wrinkles, crow's feet, pucker lines, forehead creases, and fine lines.†* Over time, users can experience visibly firmer and more lifted-looking skin, particularly in areas prone to the appearance of sagging like the jowls, neck, jawline, cheeks, and chin. Beyond skin nourishment, Beverly Hills MD Dermal Repair Complex can also provide many users with bonus benefits, including thicker-looking hair and fuller-looking lips — enhancing a youthful appearance.* What are the Key Ingredients in Beverly Hills MD Dermal Repair Complex?† Vitamin A: A potent antioxidant that acts as a protective shield against external factors like pollution and stress. It helps address visible signs of aging, including pucker lines, fine lines, crow's feet, and forehead creases.* Vitamin B: As an essential antioxidant, vitamin B supports the healthy turnover of cells, supporting visibly firmer and more lifted-looking skin.* Hyaluronic Acid: Functioning as a moisture-attracting molecule, hyaluronic acid helps visibly smooth wrinkles from the inside out, contributing to a more youthful complexion.* Saw Palmetto: Enriched with antioxidants and fatty acids, Saw Palmetto is a potent extract that helps the body fight the adverse effects of the skin-sagging hormone DHT, leading to noticeable improvements.* MSM (Methylsulfonylmethane): This organic compound works to strengthen the appearance of the skin, promoting a firmer and more radiant look.* Hydrolyzed Collagen: This easily absorbable protein is rich in essential amino acids, working to support the skin's youthful elasticity and achieve a plump, "bouncy" appearance.* The Suggested Use of Beverly Hills MD Dermal Repair Complex For optimal results, take 2 capsules of Dermal Repair Complex dietary supplement daily with 8 fl. oz. of water and a meal. Where to purchase Beverly Hills MD Dermal Repair Complex? Beverly Hills MD Dermal Repair Complex can be purchased on the Beverly Hills MD website for the purchase price of $58.00 with a 90-day money-back guarantee. About Dr. Layke and Dr. Danielpour Dr. John Layke and Dr. Payman Danielpour are renowned plastic surgeons and co-founders of the Beverly Hills Plastic Surgery Group. Both doctors trained at the prestigious Long Island Plastic Surgical Group before offering world-class procedures at their Beverly Hills clinic. In 2014, their passion for science inspired them to develop advanced ingredient formulations to help users achieve results in the comfort of their homes, and the Beverly Hills MD skincare line was born. Dr. John Layke and Payman Danielpour also launched the Forever Young Podcast and Youtube channel where they discuss beauty trends and anti-aging remedies. For more, follow them on Instagram @plastixdocs and TikTok. About Beverly Hills MD Beverly Hills MD was created by co-founders Dr. John Layke and Dr. Payman Danielpour of the innovative Beverly Hills Plastic Surgery Group. Now, with their cutting-edge skincare line, Beverly Hills MD, they're able to reach beyond the walls of their office and offer at-home "look younger" results to those looking for the very best non-surgical, anti-aging solutions available. Each product works to visibly correct the most stubborn skincare concerns. Their bestsellers include Deep Regenerating Stem Cell Moisturizer, Deep Wrinkle Filler, and Beverly Hills MD Rejuv-GH Timeless Beauty Concentrate. For the latest news, follow Beverly Hills MD on Instagram @officialbhmd and YouTube. *All individuals are unique. Your results can and will vary. Media Contact: Shari Mesulam [email protected] SOURCE Beverly Hills MD

2023-11-09

·PRNewswire

LEADING WOMEN'S WELLNESS BRAND O POSITIV ANNOUNCES THE LAUNCH OF WILLO HAIR GROWTH SUPPORT CAPSULES

Supplements Support Healthy Hair Growth and Thicker, Fuller Hair LOS ANGELES, Nov. 9, 2023 /PRNewswire/ -- O Positiv, the supplement brand breaking taboos in women's health, introduces their newest product WILLO Hair Growth Support Capsules . Continue Reading Willo Hair Growth Supplements from O Positiv O Positiv has been at the forefront of women's health since the successful launch of their debut product in 2018, FLO, the first-ever PMS support supplement on the market. The brand's mission is to prioritize and advocate for women's health, by providing effective solutions for health concerns that have been historically overlooked. With an extensive product range dedicated to addressing issues related to vaginal, digestive, urinary, menstrual and menopausal health, O Positiv has firmly established itself as a premier women's health advocate and supporter. WILLO Hair Growth Support Capsules represent O Positiv's dedication to addressing another common yet often unspoken issue for women– thinning hair. These cruelty free, vegan and gluten free supplements are designed to support healthy hair growth, enhance hair follicle health, and help manage the effects of stress on hair. The star ingredient in WILLO Hair Growth Support Capsules is Lustriva®, a patented and clinically-studied complex of biotin, arginine, and silicon known for its superior absorption into the body. Clinical studies have proven its effectiveness in supporting healthy hair growth and promoting thicker, fuller hair. "We're constantly hearing from our customers about the effect of hormonal changes on their hair growth," Co-Founder Brianna Bitton said, "We're overwhelmed by the stories of hair thinning or shedding without an effective or safe-to-take daily product. We're proud to launch WILLO to address these under-discussed issues." Thinning hair is a common concern among women, often associated with various conditions such as hormonal changes due to pregnancy, childbirth, menopause, and thyroid issues, according to the Mayo Clinic. WILLO Hair Growth Supplements aim to empower women with a solution that addresses this challenge they face throughout every stage of life. Each WILLO Hair Growth Support Capsules not only contain Lustriva® but also a variety of other vital ingredients. These include Saw Palmetto, a key ingredient that's been shown to help manage the body's levels of DHT (a hormone known to cause hair follicles to shrink), contributing to healthy follicles; Holy Basil, an adaptogen traditionally used to support healthy stress management; Vitamins E & C, well-researched antioxidants that combat oxidative stress in the body and scalp, supporting hair follicle health; and Hair & Scalp Nutrients, a blend of vitamins and minerals that help fill nutrient deficiencies that may cause thinning / brittle hair (includes selenium, iron, vitamins D3 & B12, folate and zinc). In a clinical study using an ingredient found in WILLO Hair Growth Support Capsules, women saw significant improvement in hair thickness in just 3 weeks, when taken daily. O Positiv plans to continue expanding their range of products, which currently includes favorites - FLO PMS Gummies & Capsules, GOGO Prebiotic Fiber Gummies, URO Urinary Tract & URO Vaginal Probiotic Capsules, GOGO Bloating and Gas Capsules, MENO Menopause Gummies & Capsules and RETRO Glowing Skin Gummies & Capsules. To further advocate for women's health, O Positiv works with the global nonprofit Period to end period poverty and stigma through service, education and advocacy. WILLO Hair Growth Support Capsules retail for $69.99 one time, $59.99 for a subscription at opositiv.com and amazon.com. Follow O Positiv on Instagram at @opositiv. About O Positiv O Positiv is the health and wellness brand prioritizing women by creating effective products to address health concerns that have been historically overlooked. O Positiv aims to break taboos with a line of products to address vaginal, skin, digestive, menstrual and menopausal health. For more information, visit opositiv.com. Press Contact: Shauna Aminzadeh/Break Point [email protected] SOURCE O Positiv

临床结果

2022-06-15

·PRNewswire

GIDDY LAUNCHES LINE OF CLEAN-LABEL SEXUAL HEALTH VITAMINS: GIDDY + HEALTH

Doctor Reviewed And Research-Proven With Vitamins, Minerals And Specialty Nutrients To Boost Libido, Support Hormonal Changes, And Overall Sexual Wellbeing AUSTIN, Texas, June 15, 2022 /PRNewswire/ -- Giddy, the world's largest sexual health platform, today announces the launch of Giddy + Health, a new line of clean-label vitamins specially formulated to support sexual health. The doctor reviewed line was built around rigorous scientific research to aid in sexual wellbeing including libido, men's prostate, menopause, and overall health. The microbeads inside the vegetarian capsules provide sustained release, which tends to improve absorption and help maintain optimal blood nutrient levels over time. Giddy + Health Vitamins The research-proven nutrients at efficacious doses are used while maintaining a single capsule per serving. The Giddy + Health vitamin line includes: Male Libido: Boosts vitality and performance, raises testosterone levels, increases blood flow and supports erectile dysfunction. Key ingredients include Longjack to increase sexual desire, boost athletic performance and aid in erectile dysfunction; Ashwagandha to promote healthy blood flow to the genitals, relieve stress and improve concentration; and Zinc to increase libido. Men's Prostate: Promotes a healthy prostate function, improves urinary tract health, reduces inflammation and BPH, and combats prostate enlargement. Key ingredients include Saw Palmetto to support normal prostate function by improving Dihydrotestosterone (DHT) and Prostate-Specific Antigen (PSA) levels, Stinging Nettle to promote a healthy antioxidant profile by reducing prostate inflammation and C-reactive protein levels, and Pygeum which can improve urinary flow rate and reduce nocturnal urination. Female Libido: Formulated to support healthy libido, mood and sexual function through well-studied botanical extracts and herbs including Panax Ginseng to aid in a healthy mood, cognition and subjective well-being; Ashwagandha to reduce stress, anxiety and improve the pro-libido hormonal profile; and Diindolylmethane (DIM) to help facilitate a healthy hormonal profile. Female Menopause: Formulated with Black Cohosh to help relieve hot flashes, Pueraria Mirifica which can reduce menopause symptoms, and Panax Ginseng which can support a healthy mood and improve markers of menopause. Multivitamin: Designed to help women and men get essential nutrients to support nerve function, boost cardiovascular and immune health, improve calcium metabolism and maintain healthy antioxidant balance. Giddy + Health vitamins are free of artificial colors and dyes, FDA registered and formulated in a GMP certified USA facility. All microbeads are third-party tested for purity and potency, naturally-colored and vegetarian. The vitamins can be purchased at and cost between $30-$50 per month. About Giddy: Illuminating sexual wellbeing for all, Giddy is the world's largest sexual health resource. Their team of award-winning journalists cover over 120 topics from conditions, diseases and disorders to stages of life, relationships, and much more with medically-reviewed, engaging content. Giddy is a 2021 and 2022 Digital Health Award winner. To become a free member visit SOURCE Giddy

100 项与 PPRT-321 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB14360

研发状态

适应症	最高研发状态	国家/地区	公司
前列腺增生症	终止	美国更多	PharmaPrint, Inc. 更多

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00603304 (Pubmed)	临床3期	下尿路症状	369	Saw palmetto extract	醖顧壓網壓蓋蓋蓋鹽鹽(淵觸簾夢鏇繭糧膚齋艱) = 醖觸鹽衊餘鬱繭鹹糧顧製窪餘襯簾糧鬱夢淵壓 (窪淵遞淵餘選蓋鬱簾願 )	不佳	2011-09-28
				Placebo	醖顧壓網壓蓋蓋蓋鹽鹽(淵觸簾夢鏇繭糧膚齋艱) = 餘淵廠築廠遞襯觸構窪製窪餘襯簾糧鬱夢淵壓 (窪淵遞淵餘選蓋鬱簾願 )
AUA2016	N/A	前列腺增生症 \| 下尿路症状	190	Silodosin	醖鑰憲鹹網壓蓋範願構(觸蓋醖獵願齋糧鬱艱鑰) = 範鏇築積糧構觸壓構淵鹽積夢網製艱膚鹹窪觸 (糧鬱築選蓋糧襯觸顧蓋 ) 更多	-	2016-04-01
				Silodosin plus Serenoa repens	醖鑰憲鹹網壓蓋範願構(觸蓋醖獵願齋糧鬱艱鑰) = 鑰鬱齋鑰願襯選繭願夢鹽積夢網製艱膚鹹窪觸 (糧鬱築選蓋糧襯觸顧蓋 ) 更多
NCT00603304 (CTgov)	临床3期	-	369	Saw Palmetto - weeks 24 - 48 (Saw Palmetto)	鏇廠鏇願遞鹽鹹壓襯糧(糧艱壓簾壓築範願齋鏇) = 鹹廠糧獵築憲餘蓋窪繭夢簾廠選鬱繭襯構簾襯 (觸淵蓋獵積鏇齋窪鹹餘, 壓餘積餘夢壓齋顧遞齋 ~ 網齋廠鬱獵壓糧願構鑰) 更多	-	2012-10-12
				Placebo - first 24 weeks (Placebo)	鏇廠鏇願遞鹽鹹壓襯糧(糧艱壓簾壓築範願齋鏇) = 鬱構襯窪獵積窪製蓋憲夢簾廠選鬱繭襯構簾襯 (觸淵蓋獵積鏇齋窪鹹餘, 製鑰衊淵齋襯積鹹鹽淵 ~ 襯壓鹽鏇築積窪廠醖糧) 更多
SPRITE study (Pubmed)	临床4期	下尿路症状	427	Serenoa repens + selenium + lycopene	繭觸鏇壓製夢蓋廠齋遞(鏇壓範醖襯獵膚鑰網繭) = 顧齋獵顧願願鹽醖獵廠夢糧獵鹽網構繭醖鏇積 (鏇遞憲膚構積簾糧鏇醖 )	积极	2018-08-01
				tadalafil 5 mg	繭觸鏇壓製夢蓋廠齋遞(鏇壓範醖襯獵膚鑰網繭) = 衊遞蓋壓膚觸衊網築遞夢糧獵鹽網構繭醖鏇積 (鏇遞憲膚構積簾糧鏇醖 )