作者: Cabrera Gaytán, David Alejandro ; Anguiano Hernández, Yu Mei ; Santacruz Tinoco, Clara Esperanza ; Sandoval Gutiérrez, Nancy ; Rojas Mendoza, Teresita ; Grajales Muñiz, Concepción ; Vallejos Parás, Alfonso ; Jaimes Betancourt, Leticia ; Hernández Bautista, Porfirio Felipe ; Alvarado Yaah, Julio Elias

OBJECTIVESThe objective of this study is to estimate the effectiveness of COVID-19 vaccines in people treated within the social security system whose vaccination status was reported to the epidemiological surveillance system.STUDY DESIGNCase-control study.METHODSThis was a case-control study conducted. The records of individuals with suspected cases of COVID-19 registered in the epidemiological surveillance system between February 1 and June 30, 2021, were studied. RT-qPCR was performed to determine SARS-CoV-2 infection; those with a positive result were considered cases, and those with a negative result were considered controls. The ratio between cases and controls was 1:1.3. The crude and adjusted vaccine effectiveness was considered the prevention of symptomatic infection and death and calculated as the difference between the dose and the risk, with a survival analysis among vaccinated people.RESULTSA total of 94,416 individuals were included, of whom 40,192 were considered cases and 54,224 controls; 3,781 (4.00%) had been vaccinated against COVID-19. Vaccination also proved to be a protective factor against COVID-19, especially in the population who received a second dose (OR = 0.31; 95% CI 0.28-0.35). With the application of the vaccine, there was a protective effect against mortality (OR = 0.76; 95% CI 0.66-0.87). Disease prevention was higher for the BNT162-2 mRNA vaccine (82%) followed by the ChAdOx1 vaccine (33%). In the survival analysis, vaccination provided a protective effect.CONCLUSIONSThere was a positive impact of vaccines for the prevention of symptomatic COVID-19, with a second dose generating greater efficacy and a reduction in deaths.

2021-05-06·Nature1区 · 综合性期刊

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

1区 · 综合性期刊

Article

作者: Vamos, Edith E. ; McMinn, Liz ; Coudert, Jerome D. ; Tovar-Corona, Jaime M. ; Jones, Sophie ; Gallagher, Michael D. ; Campbell, Sharon ; Nicholls, Sam ; Ribeiro, Carla ; Smith, Sean ; Owehand, Willem H. ; Hesketh, Andrew R. ; Trebes, Amy ; Swiatkowska, Agnieszka ; Jackson, David K. ; Cornell, Linda ; Sloan, Tim J. ; Ruis, Chris ; Bonner, Stephen ; Symmonds, Amanda ; Dunmore, Benjamin J. ; Siveroni, Igor ; Graham, Clive ; Livett, Rich ; Craven, Harriet ; Chapman, Michael R. ; Jorgensen, David ; Bayzid, Nadua ; Prestwood, Liam ; Robson, Samuel C. ; O’Grady, Justin ; Dudek, Monika ; Abudahab, Khalil ; Samaraweera, Buddhini ; Inglis, Stephen ; Volz, Erik M. ; Ott, Sascha ; Carden, Holli ; Craine, Noel ; Huang, Christopher ; Breuer, Judith ; Griffiths, Coline ; Harrison, Ewan M. ; Thaventhiran, James E. D. ; Harris, Julie ; Smith, Kim S. ; Aigrain, Louise ; Chillingworth, Tracey-Jane ; Grammatopoulos, Dimitris ; Smith, Louise ; Preston, Tom ; Spellman, Karla ; Glover, James ; Dodd, David ; Michael, Alice ; Zarebski, Alex E. ; Yarkoni, Natalia Savinykh ; Patel, Minal ; Hough, Nicholas ; Impey, Robert ; Sousa, Catarina ; Cumley, Nicola ; Barrett, Jeff ; Gunson, Rory N. ; Tsoleridis, Theocharis ; Berger, Duncan ; Linsdell, Sally ; Payne, Brendan A. I. ; Gourtovaia, Marina ; Southgate, Joel ; Reynolds, Nicola ; Tucker, Rachel M. ; Mahanama, Adhyana I. K. ; Bird, Paul ; McKerr, Caoimhe ; Pymont, Hannah M. ; Johnson, Kate ; Hobbs, Rhiannon ; Blane, Beth ; Jeffries, Aaron R. ; Kallepally, Kalyan ; Kay, Sally ; Turner, Lori ; Chalker, Vicki ; Gill, Harmeet K. ; Gaskin, Amy ; Halstead, Fenella ; Lewis, Daniel ; Boyd, Olivia ; Rogers, Hazel ; Groves, Natalie ; McNally, Alan ; Allen, Laura ; Beal, James ; Beale, Mathew ; Cook, Kate ; Dibling, Thomas ; Temperton, Ben ; Chaudhry, Yasmin ; Taylor, Sarah ; Kitchin, Lucy ; Nascimento, Fabricia F. ; Pelosi, Emanuela ; Aranday-Cortes, Elihu ; Mamun, Irfan ; De Lacy, Elen ; Nelson, Rachel ; Fisher, Chloe L. ; Lewis, Kevin ; Warwick-Dugdale, Joanna ; Hilvers, Ember ; Lensing, Stefanie V. ; Taha, Yusri ; Hassan-Ibrahim, Mohammed O. ; Bowen, John ; Dove, Alexander ; Matheson, Nicholas J. ; Levene, Nick ; Forrest, Sally ; Wang, Dennis ; Mookerjee, Siddharth ; Clark, Richard ; Lister, Michelle M. ; Palmer, Sophie ; Percival, Benita ; Nelson, Charlotte ; Parmar, Surendra ; Lo, Stephanie ; Garcia-Casado, Maria ; Martin, Jennifer ; Breen, Cassie ; Page, Andrew J. ; Fenton, Michael ; Soria, Carmen Diaz ; Bewshea, Claire M. ; Smith, Kenneth G. C. ; Bolt, Frances ; Williams, Charlotte A. ; Datir, Rawlings P. ; Dogga, Sunil ; Webb, Niki ; Raviprakash, Veena ; Guerin, Florence ; Quail, Michael A. ; Jackson, Kathryn A. ; Bibby, David ; Walls, Alexandra C. ; Webster, Jennifer ; Bourgeois, Yann ; Mobley, Emily ; Cerda, Alberto C. ; Jones, Christopher R. ; Balcazar, Carlos E. ; Buck, David ; Michel, Rachel ; Churcher, Carol M. ; Sycamore, Neil ; Beale, Mathew A. ; Bonsall, David ; Yong, Cissy ; Moore, Jonathan ; Bowker, Sam ; Wise, Emma ; Leonard, Steven ; Lloyd, Allyson ; Richoz, Nathan ; Richter, Alex ; Ovington, Nigel ; Bishop, Jason ; Krasheninnkova, Ksenia ; Kemp, Steven A. ; Shaaban, Sharif ; Baker, Stephen ; Hinch, Andrew ; Carlile, Matthew ; Ansaripour, Ali ; Cortes, Nick ; Hewitt, Sarah ; Coll, Francesc ; Gregory, Richard ; Aanensen, David M. ; Puethe, Christoph ; George, Ryan P. ; Silveira, Siona ; Canna, Laura ; Rushton, Steven ; Bong, Sze-How ; Petersen, Arabella ; Parmar, Aaron ; Perry, Malorie ; Li, Kathy K. ; Davidson, Rose K. ; Kwiatkowski, Dominic ; Sparkes, Andrew ; Ferrero, Marcella ; Robinson, Melanie ; Helmer, Thomas ; Thomson, Mark ; Cutts, Tim ; Moll, Robin ; De Bie, Eckart M. D. D. ; Martincorena, Inigo ; Taylor-Joyce, Grace ; Afifi, Safiah ; Pardubska, Barbora ; Polwarth, Gary ; Nice, Francesca ; Drury, Eleanor ; Walker, Matthew ; Howe, Robin ; Tang, Julian ; Higginson, Ellen E. ; Meadows, Anne ; Singer, Joshua B. ; Paterson, Steve ; Korlevic, Petra ; Dawson, Joseph ; Smith, James ; Sridhar, Sushmita ; Austin-Guest, Siobhan ; O’Brien, Sarah ; Guest, Martyn ; Bergamaschi, Laura ; Cormie, Claire ; Nelson, Andrew ; Letchford, Laura ; Sivadasan, Shanthi ; Betancor, Gilberto ; Brooklyn, Tanya ; Clarke, Catriona ; Scott, Carol ; Wells, Alan ; Beggs, Andrew ; Ceron-Gutierrez, Lourdes ; Swift, Emma ; Ball, Jonathan ; Fawke, Stuart ; Georgana, Iliana ; Beer, Robert ; Price, Jane ; Harrison, Ewan ; Bassett, Andrew R. ; Foulser, Luke ; Caputo, Daniela ; Calder, Jo ; Howson-Wells, Hannah C. ; Khakh, Manjinder ; Cox, Alison ; Barcenas-Morales, Gabriela ; Wood, Jennifer ; Bishop, Chloe ; Lanzavecchia, Antonio ; Blackburn, Kirsty ; Kourampa, Jenny ; Hunter, Adam ; Barton, Edward ; Scott, Garren ; Bower, Georgie ; Williams, Rebecca ; Iturriza-Gomara, Miren ; Simpson, David A. ; Hadjirin, Nazreen F. ; da Silva Filipe, Ana ; Kristiansen, Mark ; Townsend, Paul ; Rice, Simon ; Malone, Cassandra S. ; Whitwham, Andrew ; Meadows, Lizzie ; O’Toole, Elaine ; Laverack, Adam ; Hughes, Margaret ; Orton, Richard J. ; Stanley, Robert ; Stanton, Thomas D. ; Platt, Steven ; Freeman, Timothy M. ; Harrison, Ian ; Atkinson, Laura ; Bucca, Giselda ; Dabrera, Gavin ; Jahun, Aminu S. ; Gulliver, Huw ; Kleanthous, Matt ; Galai, Katerina ; Wantoch, Michelle ; Harrott, Alexandria ; Aggarwal, Dinesh ; Bronner, Iraad ; Dadrah, Ashok ; Salluja, Tranprit ; Morgan, Sian ; Gedny, Alex ; Attwood, Stephen W. ; McHugh, Martin P. ; Wilson, Harry D. ; Seekings, Phil ; Vernet, Gabrielle ; Machin, Nicholas W. ; Johnson, Rob ; Bicknell, Kelly ; Girgis, Sophia ; Robinson, Esther ; Stratton, Mike ; Williams, Chris ; Groves, Danielle C. ; Pinto, Dora ; Monteiro, Tiago Carvalho ; Spencer-Chapman, Michael ; Pointon, Linda ; Liddle, Jennifier ; Dockree, Cat ; Kane, Leanne ; Adams, Alexander ; Dorman, Matthew ; Bosworth, Andrew ; Fearn, Christopher ; Wilson, Mark ; Kitchen, Christine ; Szluha, Suzanne ; Eckert, Sabine ; Smith, Colin P. ; Culap, Katja ; Kumziene-Summerhayes, Sara ; Nathwani, Claire ; Robinson, Trevor I. ; Keith, Alan ; Batra, Rahul ; Sluga, Graciela ; Pellanda, Alessandra Franzetti ; Monaghan, Lynn ; Jaconi, Stefano ; Smith, Katie ; Rose, Mark ; Burton-Fanning, Shirelle ; Beaver, Charlotte ; Park, Naomi ; Scarlett, Garry P. ; Coupland, Lindsay ; Ludden, Catherine ; Patel, Vineet ; Fuller, William ; Walsh, Sarah ; Lindsey, Benjamin B. ; Long, Rhona ; Young, Gregory R. ; Wills, Mark ; Nomikou, Kyriaki ; Nimz, Tabea ; Salmon, Nicholas ; Kay, Keely ; de Oliveira Martins, Leonardo ; McCoy, Laura E. ; Berriman, Matt ; Kraemer, Moritz U. G. ; Doffinger, Rainer ; Meader, Emma J. ; Bradley, John R. ; Berry, Louise ; Lensing, Stefanie ; Casey, Anna ; Hopes, Richard ; Gould, Oliver ; Eldirdiri, Sahar ; Roberts, Connor ; Bala, Sendu ; Wastenge, Elizabeth ; Coombes, Jason ; Uphill, James ; Oszlanczi, Agnes ; Bucke, Ashlea ; Strickland, Michelle ; McKenna, James P. ; Pusok, Monika ; Brooks, Ellena ; Jones, Rachel ; Whiteley, Max ; Thomson, Nicholas ; Abnizova, Irina ; Hartman, Hassan ; Sheriff, Nicola ; Mwaura, Lucy ; Still, Ian ; Sneade, Leighton ; Constantinidou, Chrystala ; Muldoon, Francesca ; Mayho, Matthew ; Easthope, Elizabeth ; Ensell, Leah ; Debebe, Johnny ; Smith, Michelle ; Ellaby, Nicholas ; Domingo, Jason ; Francois, Sarah ; Hunter, Kelvin ; Davies, Matt ; Davis, Thomas ; Prieto, Jacqui A. ; Plowman, Deborah ; Dewar, Rebecca ; Tilly, Tobias ; Williams, Lesley-Anne ; Whiteley, Thomas ; Pacchiarini, Nicole ; Neaverson, Alexandra ; Geidelberg, Lily ; Jose, Sherly ; Linger, Rachel ; Voak, Paul ; Munn, Robert ; Holmes, Alison ; Fleming, Vicki M. ; Galvin, Anastasia ; De Marco, Anna ; Keatley, Jon-Paul ; Trotter, Alexander J. ; Alcolea-Medina, Adela ; Naydenova, Plamena ; Tong, Zhen ; Weldon, Danni ; Rudder, Steven ; Shih, Joy ; Buddenborg, Sarah Kay ; Bush, Robert ; Hall, Grant ; Nicholson, Jon ; Taylor, Ben E. W. ; Bianchi, Siro ; Langford, Cordelia F. ; McCann, Clare M. ; Lowe, Helen L. ; James, Keith ; Alam, Mohammad T. ; Nichols, Jenna ; Farbos, Audrey ; Gray, Andy ; McCluggage, Kathryn ; Mack, James ; Ragonnet-Cronin, Manon ; Meng, Bo ; Rowe, Will ; Topping, Benjamin ; Maksimovic, Joshua ; Cowell, Angela ; Widaa, Sara ; Holden, Matthew T. G. ; Danesh, John ; Crawford, Liam ; Templeton, Kate E. ; Bashton, Matthew ; Rey, Sara ; Sloper, Lisa ; Sillitoe, John ; Thurston, Scott ; Legchenko, Ekaterina ; Justice, Anita ; Torok, M. Estee ; Watkins, Joanne ; Jackson, Chris ; Langford, Cordelia ; Payne, Maggie ; Riva, Agostino ; Heyburn, David ; Eltringham, Gary ; Patel, Gaurang ; Bonfield, James ; Gray, Jennifer ; Taluy, Emma ; Dias, Joana ; Heath, Paul ; Thompson, Stacey ; Keatley, Jon ; Hornett, Gary ; Tovar-Corona, Jaime ; Le-Viet, Thanh ; Edwards, Sue ; Merrill, Tammy V. ; Durrant, Laura ; Downing, Fatima ; Densem, Aiden ; Sadri, Ramin ; De Sa, Aloka ; Sizer, Dale ; Skelton, Jason ; Fairley, Derek J. ; Storey, Nathaniel ; McHugh, Sandra ; Ruffolo, Valentina ; O’Brien, Criona ; Drummond, Lucy ; Xu-McCrae, Li ; Ormond, Doug ; Hart, Jennifer ; Lewis-Wade, Amanah ; Pandey, Sarojini ; Young, Jamie ; Joseph, Amelia ; Tordesillas, Hugo ; Hubb, Jonathan ; Holmes, Nadine ; Robertson, David L. ; Eyre, David ; Harry, Edward ; Michell, Stephen L. ; Mescia, Federica ; Blacow, Rachel ; Oliver, Karen ; Publico, Cherry ; Carmichael, Stephen N. ; Moore, Catherine ; Frost, Lucy R. ; McClintock, Jo ; Ward, Gary ; Heaney, Judith ; Moses, Samuel ; Goncalves, Sonia ; Phelan, Isabel ; Kay, Gemma L. ; Josipovic, Masa ; Kennet, Jane ; Anderson, Ralph ; Charalampous, Themoula ; Mollett, Guy ; Elmer, Anne ; Tonkin-Hill, Gerry ; Stark, Hannah ; Ariani, Cristina V. ; Gilbert, Lauren ; Jarvis, Isobel ; Saul, David ; Nebbia, Gaia ; Price, Anna ; McCarthy, Shane ; Dougherty, Martin ; Waugh, Sheila ; Flack, Neil ; Gräf, Stefan ; Yeats, Corin A. ; Ungureanu, Daniel ; Gupta, Ravindra K. ; Fordham, Howerd ; Smith, Chris ; Peacock, Sharon ; Taylor, Graham P. ; Baker, David J. ; Cagan, Alex ; Studholme, David J. ; Dabrowska, Monika ; Myers, Richard ; Patel, Amita ; Niebel, Marc O. ; Koshy, Cherian ; Silacci-Fregni, Chiara ; Souster, Emily ; Mbisa, Tamyo ; Ohan, Valeriu ; Stefanucci, Luca ; Fraser, Audrey ; Rastall, Rebecca ; Signell, Adrian W. ; Allison, John ; Watts, Joanne ; Lowe, Hannah ; Bullman, Ben ; du Plessis, Louis ; Hill, Verity ; Menegazzo, Mirko ; Klimekova, Martina ; Polgarova, Petra ; Eccles, Richard ; Van, Philip Jansen ; Chand, Meera ; Lovell, Jamie ; Elliott, Scott ; Hosmillo, Myra ; Mair, Daniel ; Adams, Helen ; Peto, Timothy ; Vipond, Ian B. ; Ratcliffe, Liz ; Raghwani, Jayna ; Simms, Alison ; King, Alison ; Loman, Nicholas J. ; Baxter, Laura ; Glaysher, Sharon ; Hutchings, Stephanie ; Rooke, Stefan ; Macfarlane-Smith, Louissa R. ; Stonehouse, Susanne ; Bridgewater, Hannah E. ; Rowan, Aileen ; Jeremiah, Sarah ; Marsden, Joe ; Caetano, Catarina ; Harper, Katherine L. ; Williams, Mia ; Bassett, Andrew ; Swindells, Emma ; Lehner, Paul J. ; Bellis, Katherine L. ; Davies, Robert ; Bunclark, Katherine ; Corti, Davide ; Pang, Yoke Fei ; Jackson, Adam ; Smith, Tina ; Weekes, Michael P. ; Madona, Pinglawathee ; Auckland, Cressida ; Gifford, Laura ; Parker, Matthew D. ; Smith, Christen ; Skeldon, Kenneth ; Crook, Derrick ; Mansfield, Jenny ; Stickland, Tim ; Morgan, Mari ; Smollett, Katherine L. ; Bronner, Iraad F. ; Meadows, Carl ; Omarjee, Ommar ; Bull, Matthew ; Furlong, Anita ; Willingham, Iona ; Harvison, Julia ; Rajan, Diana ; Sivaprakasam, Venkat ; Thomson, Emma C. ; Wright, Sean ; Berry, Lisa ; Olney, Charles ; Veesler, David ; Gallis, Marta ; Smerdon, Nathalie ; Barrett, Jeffrey ; Urbanova, Jana ; McManus, Georgina M. ; Farr, Ben ; Curran, Martin D. ; Thompson, Mark ; Wylot, Marta ; Maclean, Alasdair ; Steed, Claire ; Cook, Elizabeth ; de Cesare, Mariateresa ; Nerou, Ed ; Bellerby, Tristram ; Harrison, James W. ; Nash, Sian ; Collins, Jennifer ; Knight, Bridget A. ; Wierzbicki, Claudia ; Mayhew, Megan ; Ariani, Cristina ; Lawniczak, Mara ; Jones, Emma ; Lovell, Jon ; Hale, Antony D. ; Strezlecki, Mateusz ; Miah, Shahjahan ; Pinckert, Malte L. ; Lin, Quan ; Ellis, Pete ; Evans, Johnathan M. ; Squares, Janet ; Gallagher, Eileen ; Stockton, Joanne ; Sharma, Rahul ; Clapham-Riley, Debbie ; Weatherhogg, Charlie ; Nickbakhsh, Seema ; Greenaway, Jane ; Summers, Charlotte ; Cotic, Marius ; Chapman, Liz ; Dent, Hannah ; O’Donnell, Ciara ; Law, Katharine ; Harris, Kathryn Ann ; Webster, Hermione J. ; Plimmer, Amy ; Moore, Christopher ; Loveson, Katie F. ; Curran, Tanya ; Warne, Ben ; Hughes, Joseph ; Paul, Hannah ; Karamani, Angeliki ; Hanks, Hannah ; Boswell, Tim ; Bresner, Catherine ; Gray, Emma ; Stephens, Jonathan ; Fahey, Codie ; Taylor, Katy ; Thompson, Thomas ; Loose, Matthew W. ; Okecha, Georgina ; Craw, Sarah ; Thurston, Scott A. J. ; Lee, Jack C. D. ; Pond, Nicole ; Cheng, Jeffrey K. J. ; Bevan, Paul ; Huckle, Liz ; Holmes, Elaine ; Hamilton, William L. ; Quick, Joshua ; Lynch, Jessica ; Mahungu, Tabitha W. ; Snell, Gyorgy ; Tong, Lily ; Alikhan, Nabil-Fareed ; Perera, Marianne ; Bradley, Amanda ; Mori, Matilde ; Schaefer, Ulf ; Megram, Oliver ; Cronin, Michelle ; Haque, Tanzina ; Fina, Laia ; Verdejo, Carlos Jimenez ; Lindsay, Sarah ; Holmes, Christopher ; Snell, Luke B. ; Gutierrez, Bernardo ; Martin, Matt ; Tao, Nunu ; Blakey, Victoria ; Holland, Dave ; Johnson, Natasha ; Jesudason, Natasha G. ; Smith, Darren L. ; Bassi, Jessica ; Leek, Danielle ; Andersson, Monique ; Spencer Chapman, Michael H. ; Shankar, Giri ; Ferreira, Isabella A. T. M. ; Ash, Amy ; Redshaw, Nicholas M. ; Toshner, Mark ; Connor, Thomas R. ; Chatterton, Wendy ; Ellard, Sian ; Roy, Sunando ; Dewhurst, Eleanor ; Westwood, Luke ; Poplawski, Radoslaw ; McMurray, Claire ; Best, Angus ; Duckworth, Nichola ; Crawford, Mark ; Thornton, Alicia ; Martinez Nunez, Rocio T. ; Le Gresley, Emma ; Hartley, John A. ; Zhang, Peijun ; Jones, Hannah ; Toombs, Dee ; Collier, Dami A. ; Ahmad, Shazaad S. Y. ; Bellis, Katie ; Shirley, Lesley ; Cornwell, Clare ; Murie, Kathryn ; Partridge, David G. ; Lyons, Ronan A. ; Farr, Ben W. ; Richardson, Matt ; Acheson, Erwan ; Williams, Thomas ; Witele, Eric ; Mather, Alison E. ; Mackay, Michael ; Wells, Eloise ; Kidd, Stephen ; Brown, Julianne Rose ; Waller, Matt ; Michelsen, Michelle L. ; Bellany, Sam ; Liggett, Steven ; Padgett, Debra ; Zamudio, Marina Escalera ; Jones, Matthew ; Boughton, Nick ; Hess, Christoph ; Ali, Mozam ; Forsythe, Grace ; Redshaw, Nicholas ; Tortorici, M. Alejandra ; Keeley, Alexander J. ; Haldenby, Sam T. ; Makunin, Alex ; Morrow, Leanne ; Wyles, Matthew ; Rainbow, Lucille ; Swann, Allen ; Rawlings, Suzannah ; Pearson, Clare ; Wilson-Davies, Eleri ; Lackenby, Angie ; Graves, Barbara ; Hogsden, Wendy ; Rossi, Sabrina ; Ashcroft, Fiona ; Freeman, Adam ; Fenton, Melisa Louise ; Davies, Alisha ; Fraser, Christophe ; Parsons, Paul J. ; Lane, Greg ; Merrick, Ian ; di Stefano, Giovanni ; Sambles, Christine M. ; Schwach, Frank ; Stirrups, Kathleen E. ; Mirza, Jeremy ; Williams, Rachel J. ; Aydin, Alp ; Cottrell, Simon ; Brown, Rebecca ; Cogger, Benjamin J. ; Binley, Simon ; Spencer, Sarah ; Rowlands, Jane ; Corton, Craig ; Holmes, Sarah ; Walker, Neil ; Rudd, Luke ; Shepherd, James G. ; Wilson, Rebekah E. ; Moll, Robin J. ; Rambaut, Andrew ; Masoli, Jane A. 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Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in some areas by the higher transmission potential of the B.1.1.7 variant¹, which has now been reported in 94 countries. It is unclear whether the response of the virus to vaccines against SARS-CoV-2 on the basis of the prototypic strain will be affected by the mutations found in B.1.1.7. Here we assess the immune responses of individuals after vaccination with the mRNA-based vaccine BNT162b2². We measured neutralizing antibody responses after the first and second immunizations using pseudoviruses that expressed the wild-type spike protein or a mutated spike protein that contained the eight amino acid changes found in the B.1.1.7 variant. The sera from individuals who received the vaccine exhibited a broad range of neutralizing titres against the wild-type pseudoviruses that were modestly reduced against the B.1.1.7 variant. This reduction was also evident in sera from some patients who had recovered from COVID-19. Decreased neutralization of the B.1.1.7 variant was also observed for monoclonal antibodies that target the N-terminal domain (9 out of 10) and the receptor-binding motif (5 out of 31), but not for monoclonal antibodies that recognize the receptor-binding domain that bind outside the receptor-binding motif. Introduction of the mutation that encodes the E484K substitution in the B.1.1.7 background to reflect a newly emerged variant of concern (VOC 202102/02) led to a more-substantial loss of neutralizing activity by vaccine-elicited antibodies and monoclonal antibodies (19 out of 31) compared with the loss of neutralizing activity conferred by the mutations in B.1.1.7 alone. The emergence of the E484K substitution in a B.1.1.7 background represents a threat to the efficacy of the BNT162b2 vaccine.

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