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更新于：2025-05-07

Tioxamast

噻草司特

更新于：2025-05-07

概要

基本信息

药物类型

小分子化药

别名

ethyl-3-methoxyphenyl-4-thiazolyl-2-oxamate

靶点-

作用方式-

作用机制-

治疗领域

免疫系统疾病

在研适应症-

非在研适应症

超敏反应

原研机构

Pierre Fabre SA

在研机构-

非在研机构

Pierre Fabre SA

权益机构-

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C14H14N2O4S

InChIKeyROVWYOFNUFLLNL-UHFFFAOYSA-N

CAS号74531-88-7

关联

100 项与噻草司特相关的临床结果

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100 项与噻草司特相关的转化医学

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100 项与噻草司特相关的专利（医药）

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项与噻草司特相关的文献（医药）

2000-12-01·Biotechnology and Bioengineering2区 · 工程技术

Streamlined synthesis of substituted 2‐Aminothiazoles using tandem precipitative and polymer‐assisted reactions

2区 · 工程技术

Article

作者: Yun, Young K. ; Leung, Simon S. W. ; Porco, John A.

The tactical combination of classical product precipitation and subsequent modification of precipitated products using polymer-assisted transformations has been employed in the preparation of substituted 2-aminothiazole derivatives. 2-aminothiazoles were precipitated in parallel as hydrobromide monohydrate salts, directly redissolved, and reacted further using polymer-supported reagents to afford free-based 2-aminothiazoles, aminothiazoyloxamates, and aminothiazoylamides.

1992-07-01·International Journal of Immunopharmacology

Model of bronchial allergic inflammation in the Brown Norway rat. Pharmacological modulation

Article

作者: S. Vieu ; M. Barbara ; J. Tisne-Versailles ; N. Tisseyre ; M. Aliaga ; J.P. Tarayre

Exposure of non-sensitized Brown Norway (BN) rats to a 10%-ovalbumin aerosol induced an increase in the number of neutrophils in the broncho-alveolar lavage (BAL) fluid 3 and 6 h later but with no change in number of cells at 24 h. When the BN rats were actively sensitized (i.m. injection of 10 mg/kg ovalbumin and i.p. injection of killed Bordetella pertussis) and exposed 12-14 days later to a 10%-ovalbumin aerosol there was an increase in the number of eosinophils in the BAL fluid, maximal 24-48 h after the anaphylactic reaction. The increase in the number of neutrophils in the bronchial lumen 3 and 6 h after the anaphylactic reaction was larger than that obtained in non-specific inflammation and in contrast to this was still present 24-48 h after ovalbumin exposure. In passively sensitized BN rats exposed to ovalbumin aerosol, no inflammation appeared in the BAL fluid 24 h after the anaphylactic reaction. Various drugs, administered twice, 5 min and 5 h after the anaphylactic reaction, have been evaluated for their effects on the 24-h inflammation obtained in actively sensitized rats. Dexamethasone acetate (0.08 mg/kg i.p.) and theophylline (50 mg/kg i.p.) decreased the number of eosinophils and neutrophils. Ketotifen fumarate (12.5 mg/kg), cetirizine dihydrochloride (12.5 mg/kg), salbutamol (2 mg/kg), disodium cromoglycate (50 mg/kg) all given intraperitoneally, reduced the number of eosinophils. Tioxamast decreased the number of eosinophils at 12.5 mg/kg i.p. and by the oral route.(ABSTRACT TRUNCATED AT 250 WORDS)

1991-01-01·Synthesis

An Improved Procedure for the Preparation of AlkylN-(4-Aryl-2-thiazolyl)oxamates

作者: Bigg, Dennis C. H. ; Lesimple, Patrick

2-Amino-4-arylthiazoles I [R = 2-pyridyl, 4-MeOC₆H₄, Ph, 4-FC₆H₄, 3,4-(OCH₂CH₂O)C₆H₃, etc., R¹ = H, Me, R² = H] react with R³O₂CCO₂R³ (R³ = Et, CMe₃, Me, Bu) in the presence of sodium alkoxides at room temperature to give I [R = 2-pyridyl, 4-MeOC₆H₄, Ph, 4-FC₆H₄, 3,4-(OCH₂CH₂O)C₆H₃, R¹ = H, R² = COCO₂Et; R = 4-MeOC₆H₄, R¹ = H, R² = COCO₂CMe₃, COCO₂Me, COCO₂Bu; etc.] in high yield.

100 项与噻草司特相关的药物交易

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