A Phase III Clinical Trial to Evaluate the Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in Their Ankle for 18 Months

The objective of this study is to evaluate the efficacy and safety of Chondron (Autologus Chondrocyte) in patients with cartilage defects in their ankle for 18 months

开始日期2010-01-01

申办/合作机构

SEWON E&C Co., Ltd.

100 项与 Autologous cultured chondrocytes (Sewon Cellontech) 相关的临床结果

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100 项与 Autologous cultured chondrocytes (Sewon Cellontech) 相关的转化医学

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100 项与 Autologous cultured chondrocytes (Sewon Cellontech) 相关的专利（医药）

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项与 Autologous cultured chondrocytes (Sewon Cellontech) 相关的文献（医药）

Advanced Pharmaceutical Bulletin

An Investigation on the Regenerative Effects of Intra Articular Injection of Co-Cultured Adipose Derived Stem Cells with Chondron for Treatment of Induced Osteoarthritis

Article

作者: Soleimani Rad, Jafar ; Shafaei, Hajar ; Jacer, Sorayya

Purpose: Adipose tissue derived stem cells (ASCs) and chondrocytes are best cells for articular cartilage regeneration. Chondrocyte with peri-cellular matrix (PCM) is called chondron provides ideal microenviroment than chondrocytes. We aimed to evaluate the regenerative effects of intra-articular injection of ASCs co-cultures with chondron in induced osteoarthritis (OA). Methods: ASC, from the peri-renal fat of male rat and chondron from primary newborn rat hyaline cartilage were isolated. ASCs were cultured for at least three passages in vitro. Six weeks after OA induction, rats were randomly distributed in five groups of control, osteoarthritic, ASC, chondron and co-cultured. ASCs (10⁷), chondrons (10⁷) and combination of chondrons and ASCs (10⁷) were injected into intra-articular space of the rat knee. The effect of treatments was evaluated by macroscopic and microscopic examinations. The expression levels of collagen type ΙΙ was studied by immunohistochemistry. Results: Macroscopic appearance of the co-cultured group, showed much enhanced articular cartilage regeneration compared to ASC and chondron groups. H&E showed evidence of repair site of articular surface without erosion and fibrillation versus OA group which showed thin layer of hyaline cartilage over tidemark and spontaneous fibrocartilage formation. Metachromatic regions stained with toluidine blue were larger in treatment groups versus OA group. Strong intensity of type ΙΙ collagen staining was observed in co-culture group compared to other groups. Conclusion: Co-culture of chondrons and ASCs increased articular hyaline cartilage formation and provides a useful tool to improve limitations of each of applied cells in this model.

The Analyst3区 · 化学

Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model

3区 · 化学

Article

作者: Kuiper, N. J. ; Sulé-Suso, J. ; Yang, Y. ; Cinque, G. ; Owida, H. A. ; Rutter, A. V.

PCA score of FTIR spectra in fingerprint region for cultured chondrocytes at day 7, 14 and 21 in HA hydrogel showing that the 3D culture drove chondrocytes (CY) to chondron-like (CN) structure dynamically.

100 项与 Autologous cultured chondrocytes (Sewon Cellontech) 相关的药物交易

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