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项与 Anti-B7-H3 CAR-T (Shenzhen University General Hospital) 相关的临床试验Study on the Efficacy and Safety of CD276-targeted Chimeric Antigen Receptor T Cells (CD276 CAR-T) in Refractory Pancreatic Cancer
CD276 (B7-H3) is a member of the B7 costimulatory molecule family. Its mRNA is widely expressed in tissues, but the protein expression is limited. It is expressed in resting fibroblasts, endothelial cells, osteoblasts, amniotic fluid stem cells and other non-immune cells, and The surface of induced antigen-presenting cells and NK cells. Many studies have revealed that B7-H3 is overexpressed in a variety of tumors, including melanoma, pancreatic cancer, breast cancer, prostate cancer, colorectal cancer and other tumors, and its expression level is closely related to the poor prognosis and clinical outcome of patients . Preclinical studies have confirmed that the expression of CD276 mRNA in pancreatic cancer tissues is significantly higher than that of normal adjacent groups.
100 项与 Anti-B7-H3 CAR-T (Shenzhen University General Hospital) 相关的临床结果
100 项与 Anti-B7-H3 CAR-T (Shenzhen University General Hospital) 相关的转化医学
100 项与 Anti-B7-H3 CAR-T (Shenzhen University General Hospital) 相关的专利(医药)
100 项与 Anti-B7-H3 CAR-T (Shenzhen University General Hospital) 相关的药物交易